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Q5HWW4

- UPPP_CAMJR

UniProt

Q5HWW4 - UPPP_CAMJR

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Protein

Undecaprenyl-diphosphatase

Gene
uppP, CJE0198
Organism
Campylobacter jejuni (strain RM1221)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCJEJ195099:GJC0-203-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:CJE0198
OrganismiCampylobacter jejuni (strain RM1221)
Taxonomic identifieri195099 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000436: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421Helical; Reviewed predictionAdd
BLAST
Transmembranei41 – 6121Helical; Reviewed predictionAdd
BLAST
Transmembranei69 – 8921Helical; Reviewed predictionAdd
BLAST
Transmembranei96 – 11621Helical; Reviewed predictionAdd
BLAST
Transmembranei173 – 19321Helical; Reviewed predictionAdd
BLAST
Transmembranei207 – 22721Helical; Reviewed predictionAdd
BLAST
Transmembranei239 – 25921Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 267267Undecaprenyl-diphosphataseUniRule annotationPRO_0000151129Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi195099.CJE0198.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218356.
KOiK06153.
OMAiVIYFRNE.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00753. undec_PP_bacA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HWW4-1 [UniParc]FASTAAdd to Basket

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MENLYALILG IIEGLTEFLP ISSTGHMILG TTILGIDIDE FWKSFLIIIQ    50
LGSILAVIFV FWRKLFQGLD IWLKLAVGFF PTGVIGLFVA KYLNALFNGW 100
VVVGMLIFGG VVFILIELAH KNKQYRINSL EEISFKQAFC IGIFQSLAMI 150
PGTSRSGASI IGGLLLGFNR KVAAEFSFLL AIPTMIIATA YSIYKEPELL 200
SNANSLIPLG IGFITAFIVA VLVIKFFLKF ISKFDFIPFG IYRIILGFVF 250
FYLYYSGILN AGSEFKL 267
Length:267
Mass (Da):29,709
Last modified:February 15, 2005 - v1
Checksum:i6B61D316E03D834C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000025 Genomic DNA. Translation: AAW34792.1.
RefSeqiYP_178221.1. NC_003912.7.

Genome annotation databases

EnsemblBacteriaiAAW34792; AAW34792; CJE0198.
GeneIDi3230961.
KEGGicjr:CJE0198.
PATRICi20042108. VBICamJej134361_0203.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000025 Genomic DNA. Translation: AAW34792.1 .
RefSeqi YP_178221.1. NC_003912.7.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195099.CJE0198.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW34792 ; AAW34792 ; CJE0198 .
GeneIDi 3230961.
KEGGi cjr:CJE0198.
PATRICi 20042108. VBICamJej134361_0203.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218356.
KOi K06153.
OMAi VIYFRNE.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci CJEJ195099:GJC0-203-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00753. undec_PP_bacA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RM1221.

Entry informationi

Entry nameiUPPP_CAMJR
AccessioniPrimary (citable) accession number: Q5HWW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi