Q5HVR0 (HEMH_CAMJR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ferrochelatase
EC=4.99.1.1

Alternative name(s):
Heme synthase
Protoheme ferro-lyase

Gene names

Name:	hemH
Ordered Locus Names:	CJE0610

Organism

Campylobacter jejuni (strain RM1221) [Complete proteome] [HAMAP]

Taxonomic identifier

195099 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ferrous insertion into protoporphyrin IX. HAMAP MF_00323
Catalytic activity	Protoheme + 2 H+ = protoporphyrin + Fe2+. HAMAP MF_00323
Pathway	Porphyrin metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1. HAMAP MF_00323
Subcellular location	Cytoplasm By similarity HAMAP MF_00323.
Sequence similarities	Belongs to the ferrochelatase family.

Ontologies

Keywords
Biological process	Heme biosynthesis Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	heme biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ferrochelatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Ferrochelatase HAMAP MF_00323		PRO_1000019289
Sites
	Metal binding	185	1	Iron By similarity
	Metal binding	262	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5HVR0 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 731B50F3A3A12F57	FASTA	303	35,169
	10 20 30 40 50 60 MKLVLFLNMG GATNLQDCEV FLKNMFNDPY ILGIKNRFLR KFVAWIITKA RVKAMQENYK 70 80 90 100 110 120 KMGGKSPLNE LTQSLCDKLN LKQDEFKFDF VNLYVPPFAT EILQKYTLNA SDEIILFPLY 130 140 150 160 170 180 PHHSCTTVTS SLEVLQNEIS KQKIQAKVKT IDIFYKNELY NEMIVSHILD KKSKFDAKIL 190 200 210 220 230 240 IFSAHSLPQS IIDKGDLYEK HVNDHVEILK EKLKDHFDEF ILAYQSKLGP VKWLEPNTSD 250 260 270 280 290 300 VLANLNDKAL IYPISFCIDC SETIFELGME YKHLAKCDYD LISCPNNSDE FMKFILKYLS DLN

References

[1]

"Major structural differences and novel potential virulence mechanisms from the genomes of multiple Campylobacter species." Fouts D.E., Mongodin E.F., Mandrell R.E., Miller W.G., Rasko D.A., Ravel J., Brinkac L.M., DeBoy R.T., Parker C.T., Daugherty S.C., Dodson R.J., Durkin A.S., Madupu R., Sullivan S.A., Shetty J.U., Ayodeji M.A., Shvartsbeyn A., Schatz M.C. , Badger J.H., Fraser C.M., Nelson K.E. PLoS Biol. 3:72-85(2005) [PubMed: 15660156] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RM1221.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000025 Genomic DNA. Translation: AAW35877.1.
RefSeq	YP_178625.1. NC_003912.7.
3D structure databases
HSSP	HSSP built from PDB template 1HRK based on UniProtKB P22830.
ProteinModelPortal	Q5HVR0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HVR0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3232067.
GenomeReviews	Gene locus CJE0610 in contig CP000025_GR.
KEGG	cjr:CJE0610.
NMPDR	fig|195099.3.peg.283.
PATRIC	20042940. VBICamJej134361_0608.
TIGR	CJE0610.
Phylogenomic databases
eggNOG	COG0276.
HOGENOM	HBG697135.
OMA	CSETIFE.
ProtClustDB	PRK00035.
Enzyme and pathway databases
BioCyc	CJEJ195099:CJE_0610-MONOMER.
Family and domain databases
HAMAP	MF_00323. Ferrochelatase. [Tree]
InterPro	IPR001015. Ferrochelatase. IPR019772. Ferrochelatase_AS. [Graphical view]
KO	K01772.
PANTHER	PTHR11108. Ferrochelatase. 1 hit.
Pfam	PF00762. Ferrochelatase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00109. HemH. 1 hit.
PROSITE	PS00534. FERROCHELATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEMH_CAMJR

Accession

Primary (citable) accession number: Q5HVR0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 15, 2005
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program