Q5HVD4 (MSRA_CAMJR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA
Short name=Protein-methionine-S-oxide reductase
EC=1.8.4.11

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name=Peptide Met(O) reductase

Gene names

Name:	msrA
Ordered Locus Names:	CJE0740

Organism

Campylobacter jejuni (strain RM1221) [Complete proteome] [HAMAP]

Taxonomic identifier

195099 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	165 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 165	165	Peptide methionine sulfoxide reductase MsrA HAMAP MF_01401		PRO_0000138535
Sites
	Active site	10	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5HVD4 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 7F766B31D987B3BC	FASTA	165	19,009
	10 20 30 40 50 60 MKNIILGGGC FWCIEAVFER LKGVINTEVG YSGGKPNPSY ESVCNGDGNI EVVKINYDEK 70 80 90 100 110 120 QISLLEILIL FFKIHDPTSI DKQGEDIGIQ YRSIIFYENE EDKILAQNFI EEQQKIFSKK 130 140 150 160 IVTKISRLQT YYKAENYHQH YFINNPDQGY CQAVIAPKLQ KIQSD

References

[1]

"Major structural differences and novel potential virulence mechanisms from the genomes of multiple Campylobacter species." Fouts D.E., Mongodin E.F., Mandrell R.E., Miller W.G., Rasko D.A., Ravel J., Brinkac L.M., DeBoy R.T., Parker C.T., Daugherty S.C., Dodson R.J., Durkin A.S., Madupu R., Sullivan S.A., Shetty J.U., Ayodeji M.A., Shvartsbeyn A., Schatz M.C. , Badger J.H., Fraser C.M., Nelson K.E. PLoS Biol. 3:72-85(2005) [PubMed: 15660156] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RM1221.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000025 Genomic DNA. Translation: AAW34533.1.
RefSeq	YP_178751.1. NC_003912.7.
3D structure databases
ProteinModelPortal	Q5HVD4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HVD4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3230693.
GenomeReviews	Gene locus CJE0740 in contig CP000025_GR.
KEGG	cjr:CJE0740.
PATRIC	20043209. VBICamJej134361_0739.
TIGR	CJE0740.
Phylogenomic databases
eggNOG	COG0225.
HOGENOM	HBG748152.
OMA	EDKIVTE.
ProtClustDB	PRK14054.
Enzyme and pathway databases
BioCyc	CJEJ195099:CJE_0740-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRA_CAMJR

Accession

Primary (citable) accession number: Q5HVD4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	February 15, 2005
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program