Reviewed, UniProtKB/Swiss-Prot Q5HV77 (SYGA_CAMJR)

Names and origin

Protein names

Recommended name:
    Glycyl-tRNA synthetase alpha subunit
    EC=6.1.1.14
Alternative name(s):
    Glycine--tRNA ligase alpha subunit
      Short name=GlyRS

Gene names

Name:	glyQ
Ordered Locus Names:	CJE0804

Organism

Campylobacter jejuni (strain RM1221) [Complete proteome] [HAMAP]

Taxonomic identifier

195099 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). HAMAP MF_00254
Subunit structure	Tetramer of two alpha and two beta subunits By similarity. HAMAP MF_00254
Subcellular location	Cytoplasm HAMAP MF_00254.
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP glycine-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 287	287	Glycyl-tRNA synthetase alpha subunit HAMAP MF_00254		PRO_1000047410

Sequences

	Sequence		Length	Mass (Da)
	Q5HV77-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 314BA29BAF0BF908	FASTA	287	33,088
	10 20 30 40 50 60 MTFSQMILNL QNYWQEQGCA IMQPYDMPAG AGTFHPATFL RSLGKKPWAA AYVAPSRRPT 70 80 90 100 110 120 DGRYGENPNR LGAYYQFQVL IKPSPDNIQE LYLKSLENLG FDLKSHDIRF VEDNWESPSL 130 140 150 160 170 180 GAWGLGWEVW LDGMEVTQFT YFQQVGGIAV DLVSAEITYG LERIAMYLQN VDNVYDIVWS 190 200 210 220 230 240 EFNGEKIKYA DVHKQSEYEF SKYNFEISDV KILNEQFENS YKECKNILEQ GLALPAYDYC 250 260 270 280 MLAAHTFNLL DARGSISVAQ RQDYMLKIRE LSKNCAEIYK KNLNEAE

References

[1]

"Major structural differences and novel potential virulence mechanisms from the genomes of multiple Campylobacter species." Fouts D.E., Mongodin E.F., Mandrell R.E., Miller W.G., Rasko D.A., Ravel J., Brinkac L.M., DeBoy R.T., Parker C.T., Daugherty S.C., Dodson R.J., Durkin A.S., Madupu R., Sullivan S.A., Shetty J.U., Ayodeji M.A., Shvartsbeyn A., Schatz M.C. , Badger J.H., Fraser C.M., Nelson K.E. PLoS Biol. 3:72-85(2005) [PubMed: 15660156] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000025 Genomic DNA. Translation: AAW34589.1.
RefSeq	YP_178808.1.
3D structure databases
HSSP	HSSP built from PDB template 1J5W based on UniProtKB Q9WY59.
SMR	Q5HV77. Positions 1-279.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HV77.
Genome annotation databases
GeneID	3230754.
GenomeReviews	Gene locus CJE0804 in contig CP000025_GR.
KEGG	cjr:CJE0804.
NMPDR	fig|195099.3.peg.671.
TIGR	CJE0804.
Phylogenomic databases
eggNOG	COG0752.
HOGENOM	HBG285316.
OMA	CRRPTDG.
Enzyme and pathway databases
BioCyc	CJEJ195099:CJE_0804-MONOMER.
Family and domain databases
HAMAP	MF_00254. Gly_tRNA_synth_alpha. [Tree]
InterPro	IPR006194. Gly-tRNA-synth_II_heterodimer. IPR002310. Gly-tRNA_synth_IIc_asu. [Graphical view]
Pfam	PF02091. tRNA-synt_2e. 1 hit. [Graphical view]
PRINTS	PR01044. TRNASYNTHGA.
TIGRFAMs	TIGR00388. glyQ. 1 hit.
PROSITE	PS50861. AA_TRNA_LIGASE_II_GLYAB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYGA_CAMJR

Accession

Primary (citable) accession number: Q5HV77

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 15, 2005
Last modified:	February 9, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)