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Protein

Arginine decarboxylase

Gene

speA

Organism
Campylobacter jejuni (strain RM1221)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotationSAAS annotation
  • pyridoxal 5'-phosphateSAAS annotation

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotationSAAS annotation, Lyase

Keywords - Biological processi

Spermidine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumSAAS annotation, Pyridoxal phosphateSAAS annotation

Enzyme and pathway databases

BioCyciCJEJ195099:GJC0-875-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine decarboxylaseUniRule annotationSAAS annotation (EC:4.1.1.19UniRule annotationSAAS annotation)
Gene namesi
Name:speAImported
Ordered Locus Names:CJE0855Imported
OrganismiCampylobacter jejuni (strain RM1221)Imported
Taxonomic identifieri195099 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000436 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi195099.CJE0855.

Structurei

3D structure databases

ProteinModelPortaliQ5HV28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HV28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDYGIDIWG NENFIIKNGK VCINYEKKPA IIDIVKELRD DGYKGPLLLR
60 70 80 90 100
FPHLIQKQIE NIYGNFNKAR KEFGYKGGFN AVYPLKVNQY PGFVKNLVKL
110 120 130 140 150
GKDYNYGLEA GSKAELLLAM AYNNEGAPIT VNGFKDRELI NIGFIAAEMG
160 170 180 190 200
HNITLTIEGL NELEAIIDIA KERFKPKPNI GLRVRLHSAG VGIWAKSGGI
210 220 230 240 250
NSKFGLTSTE LIEAVNLLKE NKLLEQFTMI HFHLGSQITE IHPLKKALNE
260 270 280 290 300
AGNIYTELRK MGAKNLKAIN LGGGLAVEYS QFKNEKSRNY TLREYANDVV
310 320 330 340 350
FILKNIAEQK KDLEPDIFIE SGRFVAANHA VLIAPVLELF SQEYTENKLI
360 370 380 390 400
LKKQNPKLID ELYDLYKSIK PSNALEYLHD SIDHLESILT LFDLGYVDLQ
410 420 430 440 450
DRSNAEILTH LITKKAILLL GDKQNPADLL AIQDEVQERY LVNFSLFQSM
460 470 480 490 500
PDFWGLEQNF PIMPLDRLDE EPTRSASIWD ITCDSDGEIS YSKDKPLFLH
510 520 530 540 550
DVDVEKENYF LGFFLVGAYQ EVLGMKHNLF THPTEAIISI NEKGYEVEGI
560 570 580 590 600
IEAQSILDTL EDLDYDIHAI MDILNERISN SKLVNDKQKK HILGELYLFL
610
NDNGYLKSIG V
Length:611
Mass (Da):69,406
Last modified:February 15, 2005 - v1
Checksum:i54FA13CA714C510B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000025 Genomic DNA. Translation: AAW35192.1.
RefSeqiYP_178857.1. NC_003912.7.

Genome annotation databases

EnsemblBacteriaiAAW35192; AAW35192; CJE0855.
KEGGicjr:CJE0855.
PATRICi20043477. VBICamJej134361_0868.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000025 Genomic DNA. Translation: AAW35192.1.
RefSeqiYP_178857.1. NC_003912.7.

3D structure databases

ProteinModelPortaliQ5HV28.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi195099.CJE0855.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW35192; AAW35192; CJE0855.
KEGGicjr:CJE0855.
PATRICi20043477. VBICamJej134361_0868.

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.

Enzyme and pathway databases

BioCyciCJEJ195099:GJC0-875-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RM1221Imported.

Entry informationi

Entry nameiQ5HV28_CAMJR
AccessioniPrimary (citable) accession number: Q5HV28
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: April 1, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.