Q5HTT7 (KGUA_CAMJR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	CJE1311

Organism

Campylobacter jejuni (strain RM1221) [Complete proteome] [HAMAP]

Taxonomic identifier

195099 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity HAMAP MF_00328.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 205	205	Guanylate kinase HAMAP MF_00328		PRO_0000266300
Regions
	Domain	3 – 183	181	Guanylate kinase-like
	Nucleotide binding	10 – 17	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5HTT7 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: D9F5221A7B073A2F	FASTA	205	23,784
	10 20 30 40 50 60 MQGFVLLISG PSGAGKSTLL KKLFDEFEDE LYFSISSTTR KPREGEKNGI HYHFISHEEF 70 80 90 100 110 120 QKGIDSDHFL EWARVHENFY GTSLKHTQNA LDNGKIVVFD IDVQGFKIAR KKMADKIVSV 130 140 150 160 170 180 FITTKNKDEL KKRLIKRNTD TIIQLEKRLQ NASDEMKELS EYDYLIINDE LKQSYEALRA 190 200 ILIAHKFRTK GQNLGQIQNI WNEGE

References

[1]

"Major structural differences and novel potential virulence mechanisms from the genomes of multiple Campylobacter species." Fouts D.E., Mongodin E.F., Mandrell R.E., Miller W.G., Rasko D.A., Ravel J., Brinkac L.M., DeBoy R.T., Parker C.T., Daugherty S.C., Dodson R.J., Durkin A.S., Madupu R., Sullivan S.A., Shetty J.U., Ayodeji M.A., Shvartsbeyn A., Schatz M.C. , Badger J.H., Fraser C.M., Nelson K.E. PLoS Biol. 3:72-85(2005) [PubMed: 15660156] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RM1221.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000025 Genomic DNA. Translation: AAW35632.1.
RefSeq	YP_179298.1. NC_003912.7.
3D structure databases
HSSP	HSSP built from PDB template 1GKY based on UniProtKB P15454.
ProteinModelPortal	Q5HTT7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HTT7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3231818.
GenomeReviews	Gene locus CJE1311 in contig CP000025_GR.
KEGG	cjr:CJE1311.
PATRIC	20044422. VBICamJej134361_1329.
TIGR	CJE1311.
Phylogenomic databases
eggNOG	COG0194.
HOGENOM	HBG671982.
OMA	EWAEFAG.
ProtClustDB	PRK00300.
Enzyme and pathway databases
BioCyc	CJEJ195099:CJE_1311-MONOMER.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
KO	K00942.
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. Guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_CAMJR

Accession

Primary (citable) accession number: Q5HTT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	February 15, 2005
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program