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Protein

60 kDa chaperonin

Gene

groL

Organism
Campylobacter jejuni (strain RM1221)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperoninUniRule annotation
Alternative name(s):
GroEL proteinUniRule annotation
Protein Cpn60UniRule annotation
Gene namesi
Name:groLUniRule annotation
Synonyms:groELUniRule annotation
Ordered Locus Names:CJE1356
OrganismiCampylobacter jejuni (strain RM1221)
Taxonomic identifieri195099 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000633231 – 54560 kDa chaperoninAdd BLAST545

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ5HTP2.
SMRiQ5HTP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076290.
KOiK04077.
OMAiTDTDKME.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR037290. Cpn60/TCP-1_sf.
IPR027409. GroEL-like_apical_dom_sf.
IPR027413. GROEL-like_equatorial_sf.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HTP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKEIIFSDE ARNKLYEGVK KLNDAVKVTM GPRGRNVLIQ KSFGAPSITK
60 70 80 90 100
DGVSVAKEVE LKDSLENMGA SLVREVASKT ADQAGDGTTT ATVLAHAIFK
110 120 130 140 150
EGLRNITAGA NPIEVKRGMD KACEAIVAEL KKLSREVKDK KEIAQVATIS
160 170 180 190 200
ANSDEKIGNL IADAMEKVGK DGVITVEEAK SINDELNVVE GMQFDRGYLS
210 220 230 240 250
PYFITNAEKM TVELSSPYIL LFDKKIANLK DLLPVLEQIQ KTGKPLLIIA
260 270 280 290 300
EDIEGEALAT LVVNKLRGVL NISAVKAPGF GDRRKAMLED IAILTGGEVI
310 320 330 340 350
SEELGRTLES ATIQDLGQAS SVIIDKDNTT IVNGAGEKAN IDARVNQIKA
360 370 380 390 400
QIAETTSDYD REKLQERLAK LSGGVAVIKV GAATETEMKE KKDRVDDALS
410 420 430 440 450
ATKAAVEEGI VIGGGAALIK AKAKIKLDLQ GDEAIGAAIV ERALRAPLRQ
460 470 480 490 500
IAENAGFDAG VVVNSVENAK DENTGFDAAK GEYVNMLESG IIDPVKVERV
510 520 530 540
ALLNAVSVAS MLLTTEATIS EIKEDKPTMP DMSGMGGMGG MGGMM
Length:545
Mass (Da):57,941
Last modified:February 15, 2005 - v1
Checksum:i4C1F717A823CBC6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000025 Genomic DNA. Translation: AAW35676.1.
RefSeqiWP_002860445.1. NC_003912.7.

Genome annotation databases

EnsemblBacteriaiAAW35676; AAW35676; CJE1356.
KEGGicjr:CJE1356.

Similar proteinsi

Entry informationi

Entry nameiCH60_CAMJR
AccessioniPrimary (citable) accession number: Q5HTP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: February 15, 2005
Last modified: November 22, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families