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Protein

ATP phosphoribosyltransferase

Gene

hisG

Organism
Campylobacter jejuni (strain RM1221)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.UniRule annotation

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Enzyme regulationi

Feedback inhibited by histidine.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH 1 (hisH1), Imidazole glycerol phosphate synthase subunit HisH 2 (hisH2), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Histidine biosynthesis bifunctional protein HisB (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. Histidine biosynthesis bifunctional protein HisB (hisB)
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00031; UER00006

Names & Taxonomyi

Protein namesi
Recommended name:
ATP phosphoribosyltransferaseUniRule annotation (EC:2.4.2.17UniRule annotation)
Short name:
ATP-PRTUniRule annotation
Short name:
ATP-PRTaseUniRule annotation
Gene namesi
Name:hisGUniRule annotation
Ordered Locus Names:CJE1769
OrganismiCampylobacter jejuni (strain RM1221)
Taxonomic identifieri195099 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001518401 – 299ATP phosphoribosyltransferaseAdd BLAST299

Structurei

Secondary structure

1299
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 15Combined sources9
Helixi18 – 27Combined sources10
Beta strandi36 – 53Combined sources18
Helixi55 – 57Combined sources3
Helixi58 – 63Combined sources6
Beta strandi66 – 73Combined sources8
Helixi74 – 86Combined sources13
Beta strandi94 – 98Combined sources5
Beta strandi104 – 111Combined sources8
Helixi119 – 122Combined sources4
Beta strandi126 – 130Combined sources5
Helixi132 – 141Combined sources10
Beta strandi147 – 150Combined sources4
Helixi155 – 157Combined sources3
Turni158 – 162Combined sources5
Beta strandi165 – 172Combined sources8
Helixi178 – 180Combined sources3
Beta strandi182 – 191Combined sources10
Beta strandi193 – 197Combined sources5
Helixi204 – 223Combined sources20
Beta strandi226 – 234Combined sources9
Helixi235 – 237Combined sources3
Helixi238 – 244Combined sources7
Beta strandi248 – 250Combined sources3
Beta strandi252 – 256Combined sources5
Beta strandi259 – 270Combined sources12
Helixi271 – 283Combined sources13
Beta strandi287 – 293Combined sources7
Beta strandi295 – 298Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YB5X-ray2.24A/B/C/D/E/F1-299[»]
4YB6X-ray1.98A/B/C/D/E/F1-299[»]
4YB7X-ray2.20A/B/C/D/E/F/G/H/I/J/K/L1-299[»]
5UB9X-ray1.90A/B1-225[»]
5UBGX-ray1.90A/B1-225[»]
5UBHX-ray2.00A/B1-225[»]
5UBIX-ray2.14A/B1-225[»]
ProteinModelPortaliQ5HSJ4
SMRiQ5HSJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP phosphoribosyltransferase family. Long subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000223247
KOiK00765
OMAiYVMMDYD

Family and domain databases

Gene3Di3.30.70.120, 1 hit
HAMAPiMF_00079 HisG_Long, 1 hit
InterProiView protein in InterPro
IPR013820 ATP_PRibTrfase_cat
IPR018198 ATP_PRibTrfase_CS
IPR001348 ATP_PRibTrfase_HisG
IPR020621 ATP_PRibTrfase_HisG_long
IPR013115 HisG_C
IPR011322 N-reg_PII-like_a/b
IPR015867 N-reg_PII/ATP_PRibTrfase_C
PANTHERiPTHR21403 PTHR21403, 1 hit
PfamiView protein in Pfam
PF01634 HisG, 1 hit
PF08029 HisG_C, 1 hit
SUPFAMiSSF54913 SSF54913, 1 hit
TIGRFAMsiTIGR00070 hisG, 1 hit
TIGR03455 HisG_C-term, 1 hit
PROSITEiView protein in PROSITE
PS01316 ATP_P_PHORIBOSYLTR, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HSJ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQENTRLRIA IQKSGRLSKE SIELLSECGV KMHIHEQSLI AFSTNLPIDI
60 70 80 90 100
LRVRDDDIPG LIFDGVVDLG IIGENVLEEN ELERQSLGEN PSYKLLKKLD
110 120 130 140 150
FGYCRLSLAL PQENKFQNLK DFEGLRIATS YPQLLKRFMK ENGINYKNCT
160 170 180 190 200
LTGSVEVAPR ANLADAICDL VSSGATLQAN NLKEVKVIYE SRACLIQKEN
210 220 230 240 250
ALSKEKQALV DKIMLRVAGV MQARESKYIM LHAPKEKLDK IQALLPGVER
260 270 280 290
PTILPLAHDE KNVALHMVSK ENLFWETMEA LKEEGASSIL VLPIEKMLK
Length:299
Mass (Da):33,639
Last modified:February 15, 2005 - v1
Checksum:i9362C62019697F4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000025 Genomic DNA Translation: AAW36193.1
RefSeqiWP_002858407.1, NC_003912.7

Genome annotation databases

EnsemblBacteriaiAAW36193; AAW36193; CJE1769
KEGGicjr:CJE1769

Similar proteinsi

Entry informationi

Entry nameiHIS1_CAMJR
AccessioniPrimary (citable) accession number: Q5HSJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

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