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Q5HSJ3

- HISX_CAMJR

UniProt

Q5HSJ3 - HISX_CAMJR

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Protein

Histidinol dehydrogenase

Gene
hisD, CJE1770
Organism
Campylobacter jejuni (strain RM1221)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei234 – 2341Substrate By similarity
Metal bindingi256 – 2561Zinc By similarity
Binding sitei256 – 2561Substrate By similarity
Metal bindingi259 – 2591Zinc By similarity
Binding sitei259 – 2591Substrate By similarity
Active sitei323 – 3231Proton acceptor By similarity
Active sitei324 – 3241Proton acceptor By similarity
Binding sitei324 – 3241Substrate By similarity
Metal bindingi357 – 3571Zinc By similarity
Binding sitei357 – 3571Substrate By similarity
Binding sitei411 – 4111Substrate By similarity
Metal bindingi416 – 4161Zinc By similarity
Binding sitei416 – 4161Substrate By similarity

GO - Molecular functioni

  1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciCJEJ195099:GJC0-1800-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:CJE1770
OrganismiCampylobacter jejuni (strain RM1221)
Taxonomic identifieri195099 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesCampylobacteraceaeCampylobacter
ProteomesiUP000000436: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 428428Histidinol dehydrogenaseUniRule annotationPRO_0000135752Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi195099.CJE1770.

Structurei

3D structure databases

ProteinModelPortaliQ5HSJ3.
SMRiQ5HSJ3. Positions 3-428.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiCAIANRI.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HSJ3-1 [UniParc]FASTAAdd to Basket

« Hide

MQILVYDNLD EKQKEEALKR PAISAKDEIS KIVSSIIKEV QEKGDEALIE    50
QALKFDKAEI SKIKITQEEI TQASKRLDKD LQEAILVAYE NIKKFHEAQI 100
PHEIALETTK GVKCEVLTRP IEKVGLYIPG GLAPLFSTVL MLAIPAKIAG 150
CEKIVLASPA KINDAVLFCA KLCGVDEIYQ MGGAGAIAAL AYGTQSVLKV 200
DKIFGPGNAF VTEAKRQVSS DINGAAIDMQ AGPSEVLVIA DDLANEKFVA 250
SDLLSQAEHG ADSQVILVCL SQDFAKKASD EVQSQLELLP RKELASKSIA 300
NSRIIIAKDL NQALEISNLY APEHLIIQTQ NPRELLKGVK HAGSVFLGAY 350
SPESMGDYAS GTNHVLPTYG LTKTHSSLGL ADFSKRMTVQ ELSKEGFLAL 400
GKSVEILAQN EHLDAHKNAV TFRLESLK 428
Length:428
Mass (Da):46,430
Last modified:February 15, 2005 - v1
Checksum:iEF20C2265EBABBE6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000025 Genomic DNA. Translation: AAW36194.1.
RefSeqiYP_179742.1. NC_003912.7.

Genome annotation databases

EnsemblBacteriaiAAW36194; AAW36194; CJE1770.
GeneIDi3232397.
KEGGicjr:CJE1770.
PATRICi20045350. VBICamJej134361_1786.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000025 Genomic DNA. Translation: AAW36194.1 .
RefSeqi YP_179742.1. NC_003912.7.

3D structure databases

ProteinModelPortali Q5HSJ3.
SMRi Q5HSJ3. Positions 3-428.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 195099.CJE1770.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW36194 ; AAW36194 ; CJE1770 .
GeneIDi 3232397.
KEGGi cjr:CJE1770.
PATRICi 20045350. VBICamJej134361_1786.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi CAIANRI.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci CJEJ195099:GJC0-1800-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RM1221.

Entry informationi

Entry nameiHISX_CAMJR
AccessioniPrimary (citable) accession number: Q5HSJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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