Reviewed, UniProtKB/Swiss-Prot Q5HSF8 (RNC_CAMJR)

Names and origin

Protein names

Recommended name:
    Ribonuclease 3
    EC=3.1.26.3
Alternative name(s):
    Ribonuclease III
      Short name=RNase III

Gene names

Name:	rnc
Ordered Locus Names:	CJE1807

Organism

Campylobacter jejuni (strain RM1221) [Complete proteome] [HAMAP]

Taxonomic identifier

195099 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs By similarity.
Catalytic activity	Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP MF_00104
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Contains 1 DRBM (double-stranded RNA-binding) domain. Contains 1 RNase III domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	RNA-binding
Molecular function	Endonuclease Hydrolase Nuclease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mRNA processing Inferred from electronic annotation. Source: HAMAP rRNA catabolic process Inferred from electronic annotation. Source: InterPro rRNA processing Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	double-stranded RNA binding Inferred from electronic annotation. Source: InterPro ribonuclease III activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	Ribonuclease 3 HAMAP MF_00104		PRO_0000228511
Regions
	Domain	4 – 127	124	RNase III
	Domain	154 – 223	70	DRBM

Sequences

	Sequence		Length	Mass (Da)
	Q5HSF8-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: B52BD8DADBCAB2E5	FASTA	224	25,084
	10 20 30 40 50 60 MKNIEKLERS LTYEFKDKNL LIHALTHKSF KKSYNNERLE FLGDAVLDLV VGEYLFHKFA 70 80 90 100 110 120 KDAEGDLSKL RAALVNEKSF AKIANSLNLG DFIFMSVAEE NNGGREKPSI LSDALEAIIG 130 140 150 160 170 180 AIHLEAGFEF TKTIALRLIE KNFPQIDAKI LIKDYKTKLQ EITQGKIGQT PQYETVRAFG 190 200 210 220 PDHLKQFEIA LMLDGKELAR AIAGSKKEAQ QMAAKIALEK LGAL

References

[1]

"Major structural differences and novel potential virulence mechanisms from the genomes of multiple Campylobacter species." Fouts D.E., Mongodin E.F., Mandrell R.E., Miller W.G., Rasko D.A., Ravel J., Brinkac L.M., DeBoy R.T., Parker C.T., Daugherty S.C., Dodson R.J., Durkin A.S., Madupu R., Sullivan S.A., Shetty J.U., Ayodeji M.A., Shvartsbeyn A., Schatz M.C. , Badger J.H., Fraser C.M., Nelson K.E. PLoS Biol. 3:72-85(2005) [PubMed: 15660156] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000025 Genomic DNA. Translation: AAW36229.1.
RefSeq	YP_179777.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HSF8.
Genome annotation databases
GeneID	3232434.
GenomeReviews	Gene locus CJE1807 in contig CP000025_GR.
KEGG	cjr:CJE1807.
NMPDR	fig|195099.3.peg.1333.
TIGR	CJE1807.
Phylogenomic databases
HOGENOM	Q5HSF8.
OMA	ALTHKSF.
Enzyme and pathway databases
BioCyc	CJEJ195099:CJE_1807-MON.
Family and domain databases
HAMAP	MF_00104. [Tree]
InterPro	IPR001159. Ds-RNA_bd. IPR014720. dsRNA-bd-like. IPR000999. RNase_III. IPR011907. RNase_III_bac. [Graphical view]
Gene3D	G3DSA:3.30.160.20. dsRNA-bd-like. 1 hit. G3DSA:1.10.1520.10. RNase_III. 1 hit.
Pfam	PF00035. dsrm. 1 hit. PF00636. Ribonuclease_3. 1 hit. [Graphical view]
SMART	SM00358. DSRM. 1 hit. SM00535. RIBOc. 1 hit. [Graphical view]
TIGRFAMs	TIGR02191. RNaseIII. 1 hit.
PROSITE	PS50137. DS_RBD. 1 hit. PS00517. RNASE_3_1. 1 hit. PS50142. RNASE_3_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RNC_CAMJR

Accession

Primary (citable) accession number: Q5HSF8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	February 15, 2005
Last modified:	November 3, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)