Reviewed,
UniProtKB/Swiss-Prot Q5HSB7 (MURB_CAMJR)
Last modified
February 9, 2010.
Version 38.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: UDP-N-acetylenolpyruvoylglucosamine reductase EC=1.1.1.158 Alternative name(s): UDP-N-acetylmuramate dehydrogenase | ||||
| Gene names |
| ||||
| Organism | Campylobacter jejuni (strain RM1221) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 195099 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Epsilonproteobacteria › Campylobacterales › Campylobacteraceae › Campylobacter |
Protein attributes
| Sequence length | 258 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Cell wall formation By similarity. HAMAP MF_00037 |
| Catalytic activity | UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. HAMAP MF_00037 |
| Cofactor | FAD By similarity. HAMAP MF_00037 |
| Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00037 |
| Subcellular location | Cytoplasm Probable HAMAP MF_00037. |
| Sequence similarities | Belongs to the murB family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 258 | 258 | UDP-N-acetylenolpyruvoylglucosamine reductase HAMAP MF_00037 | PRO_0000179191 | |||||
Sites | |||||||||
| Active site | 142 | 1 | By similarity | ||||||
| Active site | 184 | 1 | Proton donor By similarity | ||||||
| Active site | 254 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Major structural differences and novel potential virulence mechanisms from the genomes of multiple Campylobacter species." Fouts D.E., Mongodin E.F., Mandrell R.E., Miller W.G., Rasko D.A., Ravel J., Brinkac L.M., DeBoy R.T., Parker C.T., Daugherty S.C., Dodson R.J., Durkin A.S., Madupu R., Sullivan S.A., Shetty J.U., Ayodeji M.A., Shvartsbeyn A., Schatz M.C. Nelson K.E.PLoS Biol. 3:72-85(2005) [PubMed: 15660156] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000025 Genomic DNA. Translation: AAW36270.1. |
| RefSeq | YP_179818.1. |
3D structure databases | |
| SMR | Q5HSB7. Positions 5-258. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q5HSB7. |
Genome annotation databases | |
| GeneID | 3232475. |
| GenomeReviews | Gene locus CJE1848 in contig CP000025_GR. |
| KEGG | cjr:CJE1848. |
| NMPDR | fig|195099.3.peg.1789. |
| TIGR | CJE1848. |
Phylogenomic databases | |
| eggNOG | COG0812. |
| HOGENOM | HBG686573. |
| OMA | LVKMNAG. |
Enzyme and pathway databases | |
| BioCyc | CJEJ195099:CJE_1848-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00037. MurB. [Tree] |
| InterPro | IPR016169. CO_DH_flavot_FAD-bd_sub2. IPR016166. FAD-bd_2. IPR003170. MurB. IPR011601. MurB_C. [Graphical view] |
| Gene3D | G3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit. G3DSA:3.90.78.10. MurB_C. 1 hit. |
| PANTHER | PTHR21071. MurB. 1 hit. |
| Pfam | PF02873. MurB_C. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00179. murB. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | MURB_CAMJR | ||||||||
| Accession | Primary (citable) accession number: Q5HSB7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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