Q5HRY1 (AHPC_STAEQ) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 50.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Alkyl hydroperoxide reductase subunit C EC=1.11.1.15 Alternative name(s): Peroxiredoxin Thioredoxin peroxidase | ||||
| Gene names |
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| Organism | Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 176279 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Staphylococcus |
Protein attributes
| Sequence length | 189 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Directly reduces organic hydroperoxides in its reduced dithiol form By similarity. |
| Catalytic activity | 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. |
| Subunit structure | Homodimer; disulfide-linked, upon oxidation By similarity. |
| Post-translational modification | The Cys-49-SH group is the primary site of oxidation by H2O2, and the oxidized Cys-49 (probably Cys-SOH) rapidly reacts with Cys-168-SH of the other subunit to form an intermolecular disulfide. This disulfide is subsequently reduced by thioredoxin By similarity. |
| Sequence similarities | Belongs to the AhpC/TSA family. Contains 1 thioredoxin domain. |
Ontologies
| Keywords | |
|---|---|
| Domain | Redox-active center |
| Molecular function | Antioxidant Oxidoreductase Peroxidase |
| PTM | Disulfide bond |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Molecular function | peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW peroxiredoxin activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 189 | 189 | Alkyl hydroperoxide reductase subunit C | PRO_0000135130 | |||||
Regions | |||||||||
| Domain | 2 – 159 | 158 | Thioredoxin | ||||||
Sites | |||||||||
| Active site | 49 | 1 | Cysteine sulfenic acid (-SOH) intermediate By similarity | ||||||
Amino acid modifications | |||||||||
| Disulfide bond | 49 | Interchain (with C-168); in linked form By similarity | |||||||
| Disulfide bond | 168 | Interchain (with C-49); in linked form By similarity | |||||||
Sequences
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References
| [1] | "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. Fraser C.M.J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35984 / RP62A. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000029 Genomic DNA. Translation: AAW53451.1. |
| RefSeq | YP_187658.1. NC_002976.3. |
3D structure databases | |
| ProteinModelPortal | Q5HRY1. |
| SMR | Q5HRY1. Positions 2-168. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q5HRY1. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBSTAT00000042920; EBSTAP00000041463; EBSTAG00000042918. |
| GeneID | 3242975. |
| GenomeReviews | Gene locus SERP0060 in contig CP000029_GR. |
| KEGG | ser:SERP0060. |
| NMPDR | fig|176279.3.peg.289. |
| PATRIC | 19610975. VBIStaEpi130894_0054. |
| TIGR | SERP0060. |
Phylogenomic databases | |
| eggNOG | COG0450. |
| GeneTree | EBGT00050000024736. |
| HOGENOM | HBG493509. |
| OMA | GDLADHY. |
| ProtClustDB | CLSK884603. |
Enzyme and pathway databases | |
| BioCyc | SEPI176279:SERP0060-MONOMER. |
Family and domain databases | |
| InterPro | IPR017559. AhpC. IPR000866. AhpC/TSA. IPR024706. Peroxiredoxin_AhpC-typ. IPR012336. Thioredoxin-like_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit. |
| KO | K03386. |
| PANTHER | PTHR10681:SF7. PTHR10681:SF7. 1 hit. |
| Pfam | PF00578. AhpC-TSA. 1 hit. [Graphical view] |
| PIRSF | PIRSF000239. AHPC. 1 hit. |
| SUPFAM | SSF52833. Thiordxn-like_fd. 1 hit. |
| TIGRFAMs | TIGR03137. AhpC. 1 hit. |
| PROSITE | PS51352. THIOREDOXIN_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AHPC_STAEQ | ||||||||
| Accession | Primary (citable) accession number: Q5HRY1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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