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Q5HRU2

- SLE1_STAEQ

UniProt

Q5HRU2 - SLE1_STAEQ

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Protein
N-acetylmuramoyl-L-alanine amidase sle1
Gene
sle1, aaa, SERP0100
Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Peptidoglycan hydrolase involved in the splitting of the septum during cell division By similarity.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC

GO - Biological processi

  1. barrier septum assembly Source: UniProtKB-KW
  2. cytolysis Source: UniProtKB-KW
  3. defense response to bacterium Source: UniProtKB-KW
  4. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell wall biogenesis/degradation, Septation, Virulence

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-99-MONOMER.

Protein family/group databases

CAZyiCBM50. Carbohydrate-Binding Module Family 50.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase sle1 (EC:3.5.1.28)
Gene namesi
Name:sle1
Synonyms:aaa
Ordered Locus Names:SERP0100
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000531: Chromosome

Subcellular locationi

Secreted By similarity. Cell surface By similarity

GO - Cellular componenti

  1. cell surface Source: UniProtKB-SubCell
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 324299N-acetylmuramoyl-L-alanine amidase sle1
PRO_0000231627Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP0100.

Structurei

3D structure databases

ProteinModelPortaliQ5HRU2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati29 – 7143LysM 1
Add
BLAST
Repeati86 – 12843LysM 2
Add
BLAST
Repeati149 – 19143LysM 3
Add
BLAST
Domaini200 – 324125Peptidase C51
Add
BLAST

Sequence similaritiesi

Contains 3 LysM repeats.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG3942.
HOGENOMiHOG000279823.
OMAiEMNYSAS.
OrthoDBiEOG6GTZPF.

Family and domain databases

Gene3Di3.10.350.10. 3 hits.
InterProiIPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view]
PfamiPF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTiSM00257. LysM. 3 hits.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 3 hits.
PROSITEiPS50911. CHAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5HRU2-1 [UniParc]FASTAAdd to Basket

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MQKKYITAII GTTALSALAS THAQAATTHT VKSGESVWSI SHKYGISIAK    50
LKSLNGLTSN LIFPNQVLKV SGSSSRATST NSGTVYTVKA GDSLSSIAAK 100
YGTTYQKIMQ LNGLNNYLIF PGQKLKVSGK ATSSSRAKAS GSSGRTATYT 150
VKYGDSLSAI ASKYGTTYQK IMQLNGLTNF FIYPGQKLKV PGGSSSSSSS 200
NNTRSNGGYY SPTFNHQNLY TWGQCTWHVF NRRAEIGKGI STYWWNANNW 250
DNASAADGYT IDYRPTVGSI AQTDAGYYGH VAFVERVNSD GSILVSEMNW 300
SAAPGNMTYR TIPAYQVRNY KFIH 324
Length:324
Mass (Da):35,075
Last modified:February 15, 2005 - v1
Checksum:iAE24C366090455F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW53528.1.
RefSeqiYP_187697.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW53528; AAW53528; SERP0100.
GeneIDi3241005.
KEGGiser:SERP0100.
PATRICi19611053. VBIStaEpi130894_0093.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW53528.1 .
RefSeqi YP_187697.1. NC_002976.3.

3D structure databases

ProteinModelPortali Q5HRU2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176279.SERP0100.

Protein family/group databases

CAZyi CBM50. Carbohydrate-Binding Module Family 50.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW53528 ; AAW53528 ; SERP0100 .
GeneIDi 3241005.
KEGGi ser:SERP0100.
PATRICi 19611053. VBIStaEpi130894_0093.

Phylogenomic databases

eggNOGi COG3942.
HOGENOMi HOG000279823.
OMAi EMNYSAS.
OrthoDBi EOG6GTZPF.

Enzyme and pathway databases

BioCyci SEPI176279:GJJB-99-MONOMER.

Family and domain databases

Gene3Di 3.10.350.10. 3 hits.
InterProi IPR007921. CHAP_dom.
IPR018392. LysM_dom.
[Graphical view ]
Pfami PF05257. CHAP. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view ]
SMARTi SM00257. LysM. 3 hits.
[Graphical view ]
SUPFAMi SSF54106. SSF54106. 3 hits.
PROSITEi PS50911. CHAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62A.

Entry informationi

Entry nameiSLE1_STAEQ
AccessioniPrimary (citable) accession number: Q5HRU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 15, 2005
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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