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Protein

N-acetylmuramoyl-L-alanine amidase sle1

Gene

sle1

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Peptidoglycan hydrolase involved in the splitting of the septum during cell division.By similarity

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial, Bacteriolytic enzyme, Hydrolase
Biological processCell cycle, Cell division, Cell wall biogenesis/degradation, Septation, Virulence

Protein family/group databases

CAZyiCBM50 Carbohydrate-Binding Module Family 50

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase sle1 (EC:3.5.1.28)
Gene namesi
Name:sle1
Synonyms:aaa
Ordered Locus Names:SERP0100
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000531 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000023162726 – 324N-acetylmuramoyl-L-alanine amidase sle1Add BLAST299

Proteomic databases

PRIDEiQ5HRU2

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP0100

Structurei

3D structure databases

ProteinModelPortaliQ5HRU2
SMRiQ5HRU2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 70LysM 1PROSITE-ProRule annotationAdd BLAST44
Domaini84 – 127LysM 2PROSITE-ProRule annotationAdd BLAST44
Domaini147 – 190LysM 3PROSITE-ProRule annotationAdd BLAST44
Domaini200 – 324Peptidase C51PROSITE-ProRule annotationAdd BLAST125

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG41068JE Bacteria
COG1388 LUCA
COG3942 LUCA
HOGENOMiHOG000279823
KOiK22409
OMAiNTPVFNH

Family and domain databases

CDDicd00118 LysM, 3 hits
Gene3Di3.10.350.10, 3 hits
InterProiView protein in InterPro
IPR007921 CHAP_dom
IPR018392 LysM_dom
IPR036779 LysM_dom_sf
PfamiView protein in Pfam
PF05257 CHAP, 1 hit
PF01476 LysM, 3 hits
SMARTiView protein in SMART
SM00257 LysM, 3 hits
PROSITEiView protein in PROSITE
PS50911 CHAP, 1 hit
PS51782 LYSM, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5HRU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKKYITAII GTTALSALAS THAQAATTHT VKSGESVWSI SHKYGISIAK
60 70 80 90 100
LKSLNGLTSN LIFPNQVLKV SGSSSRATST NSGTVYTVKA GDSLSSIAAK
110 120 130 140 150
YGTTYQKIMQ LNGLNNYLIF PGQKLKVSGK ATSSSRAKAS GSSGRTATYT
160 170 180 190 200
VKYGDSLSAI ASKYGTTYQK IMQLNGLTNF FIYPGQKLKV PGGSSSSSSS
210 220 230 240 250
NNTRSNGGYY SPTFNHQNLY TWGQCTWHVF NRRAEIGKGI STYWWNANNW
260 270 280 290 300
DNASAADGYT IDYRPTVGSI AQTDAGYYGH VAFVERVNSD GSILVSEMNW
310 320
SAAPGNMTYR TIPAYQVRNY KFIH
Length:324
Mass (Da):35,075
Last modified:February 15, 2005 - v1
Checksum:iAE24C366090455F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA Translation: AAW53528.1
RefSeqiWP_001829380.1, NC_002976.3

Genome annotation databases

EnsemblBacteriaiAAW53528; AAW53528; SERP0100
KEGGiser:SERP0100

Similar proteinsi

Entry informationi

Entry nameiSLE1_STAEQ
AccessioniPrimary (citable) accession number: Q5HRU2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health