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Protein

ATP-dependent Clp protease ATP-binding subunit ClpC

Gene

clpC

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi208 – 215ATPSequence analysis8
Nucleotide bindingi545 – 552ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent Clp protease ATP-binding subunit ClpC
Gene namesi
Name:clpC
Ordered Locus Names:SERP0165
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000531 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002696881 – 817ATP-dependent Clp protease ATP-binding subunit ClpCAdd BLAST817

Proteomic databases

PRIDEiQ5HRM8.

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP0165.

Structurei

3D structure databases

ProteinModelPortaliQ5HRM8.
SMRiQ5HRM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini417 – 452UVRPROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni163 – 410IAdd BLAST248
Regioni471 – 662IIAdd BLAST192

Sequence similaritiesi

Belongs to the ClpA/ClpB family. ClpC subfamily.Curated

Phylogenomic databases

eggNOGiENOG4105C2Z. Bacteria.
COG0542. LUCA.
HOGENOMiHOG000218210.
KOiK03696.
OMAiHHKVRIK.

Family and domain databases

Gene3Di1.10.1780.10. 2 hits.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR019489. Clp_ATPase_C.
IPR004176. Clp_N.
IPR036628. Clp_N_dom_sf.
IPR001270. ClpA/B.
IPR018368. ClpA/B_CS1.
IPR028299. ClpA/B_CS2.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
PF07724. AAA_2. 1 hit.
PF02861. Clp_N. 2 hits.
PF10431. ClpB_D2-small. 1 hit.
PF02151. UVR. 1 hit.
PRINTSiPR00300. CLPPROTEASEA.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SM01086. ClpB_D2-small. 1 hit.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF81923. SSF81923. 1 hit.
PROSITEiView protein in PROSITE
PS00870. CLPAB_1. 1 hit.
PS00871. CLPAB_2. 1 hit.
PS50151. UVR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HRM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFGRLTERA QRVLAHAQEE AIRLNHSNIG TEHLLLGLMK EPEGIAAKVL
60 70 80 90 100
VSFNITEDKV IEEVEKLIGH GQEQMGTLHY TPRAKKVIEL SMDEARKLHH
110 120 130 140 150
NFVGTEHILL GLIRENEGVA ARVFANLDLN ITKARAQVVK ALGSPEMSNK
160 170 180 190 200
NAQANKSNNT PTLDGLARDL TVIAKDGTLD PVVGRDKEIT RVIEVLSRRT
210 220 230 240 250
KNNPVLIGEP GVGKTAIAEG LAQAIVKNEV PETLKDKRVM SLDMGTVVAG
260 270 280 290 300
TKYRGEFEER LKKVMEEIHQ AGNVILFIDE LHTLVGAGGA EGAIDASNIL
310 320 330 340 350
KPALARGELQ CIGATTLDEY RKNIEKDAAL ERRFQPIQVD EPTVEDTIEI
360 370 380 390 400
LKGLRDRYEA HHRINISDEA LEAAAKLSDR YVSDRFLPDK AIDLIDEASS
410 420 430 440 450
KVRLKSHTTP SNLKEIEQEI DKVKNEKDAA VHAQEFENAA NLRDKQSKLE
460 470 480 490 500
KQYEDAKNEW KNAQGGLDTA LSEENIAEVI AGWTGIPLTK INETESDRLL
510 520 530 540 550
NLEDTLHKRV IGQNDAVNSI SKAVRRARAG LKDPKRPIGS FIFLGPTGVG
560 570 580 590 600
KTELARALAE SMFGEDDAMI RVDMSEFMEK HAVSRLVGAP PGYVGHDDGG
610 620 630 640 650
QLTEKVRRKP YSVILFDEIE KAHPDVFNIL LQVLDDGHLT DTKGRTVDFR
660 670 680 690 700
NTVIIMTSNV GAQELQDQRF AGFGGASEGS DYETVRKTMM KELKNSFRPE
710 720 730 740 750
FLNRVDDIIV FHKLTKDELK EIVTMMVNKL THRLSEQNIN IVVTDKAKEK
760 770 780 790 800
IAEEGYDPEY GARPLIRAIQ KTVEDNLSEL ILDGNKIEGK EVTIDHDGKE
810
FKYDIYEITA KKETTES
Length:817
Mass (Da):91,012
Last modified:February 15, 2005 - v1
Checksum:i76E6455923462294
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW53548.1.
RefSeqiWP_002445729.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW53548; AAW53548; SERP0165.
KEGGiser:SERP0165.

Similar proteinsi

Entry informationi

Entry nameiCLPC_STAEQ
AccessioniPrimary (citable) accession number: Q5HRM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: February 15, 2005
Last modified: October 25, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families