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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-203-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:SERP0183
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000531 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11831183DNA-directed RNA polymerase subunit betaPRO_0000047966Add
BLAST

Proteomic databases

PRIDEiQ5HRL0.

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Protein-protein interaction databases

STRINGi176279.SERP0183.

Structurei

3D structure databases

ProteinModelPortaliQ5HRL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiEOG6M9DS6.

Family and domain databases

Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 3 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HRL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGQVVQYGR HRKRRNYARI SEVLELPNLI EIQTKSYDWF LKEGLLEMFR
60 70 80 90 100
DISPIEDFTG NLSLEFVDYR LGEPKYDLEE SKNRDATYAA PLRVKVRLII
110 120 130 140 150
KETGEVKEQE VFMGDFPLMT DTGTFVINGA ERVIVSQLVR SPSVYFNEKI
160 170 180 190 200
DKNGRENYDA TIIPNRGAWL EYETDAKDVV YVRIDRTRKL PLTVLLRALG
210 220 230 240 250
FSTDQEIVDL LGDSEYLRNT LEKDGTENTE QALLEIYERL RPGEPPTVEN
260 270 280 290 300
AKSLLYSRFF DPKRYDLASV GRYKANKKLH LKHRLFNQKL AEPIVNSETG
310 320 330 340 350
EIVVDEGTVL DRRKLDEIMD VLETNANSEV FELEGSVIDE PVEIQSIKVY
360 370 380 390 400
VPNDEEGRTT TVIGNALPDS EVKCITPADI VASMSYFFNL LNGIGYTDDI
410 420 430 440 450
DHLGNRRLRS VGELLQNQFR IGLSRMERVV RERMSIQDTD SITPQQLINI
460 470 480 490 500
RPVIASIKEF FGSSQLSQFM DQANPLAELT HKRRLSALGP GGLTRERAQM
510 520 530 540 550
EVRDVHYSHY GRMCPIETPE GPNIGLINSL SSYARVNEFG FIETPYRKVD
560 570 580 590 600
LDTNSITDQI DYLTADEEDS YVVAQANSRL DENGRFLDDE VVCRFRGNNT
610 620 630 640 650
VMAKEKMDYM DVSPKQVVSA ATACIPFLEN DDSNRALMGA NMQRQAVPLM
660 670 680 690 700
NPEAPFVGTG MEHVAARDSG AAITAKHRGR VEHVESNEIL VRRLVEENGT
710 720 730 740 750
EHEGELDRYP LAKFKRSNSG TCYNQRPIVS IGDVVEYNEI LADGPSMELG
760 770 780 790 800
EMALGRNVVV GFMTWDGYNY EDAVIMSERL VKDDVYTSIH IEEYESEARD
810 820 830 840 850
TKLGPEEITR DIPNVSESAL KNLDDRGIVY VGAEVKDGDI LVGKVTPKGV
860 870 880 890 900
TELTAEERLL HAIFGEKARE VRDTSLRVPH GAGGIVLDVK VFNREEGDDT
910 920 930 940 950
LSPGVNQLVR VYIVQKRKIH VGDKMCGRHG NKGVISKIVP EEDMPYLPDG
960 970 980 990 1000
RPIDIMLNPL GVPSRMNIGQ VLELHLGMAA KNLGIHVASP VFDGANDDDV
1010 1020 1030 1040 1050
WSTIEEAGMA RDGKTVLYDG RTGEPFDNRI SVGVMYMLKL AHMVDDKLHA
1060 1070 1080 1090 1100
RSTGPYSLVT QQPLGGKAQF GGQRFGEMEV WALEAYGAAY TLQEILTYKS
1110 1120 1130 1140 1150
DDTVGRVKTY ESIVKGENIS RPSVPESFRV LMKELQSLGL DVKVMDEHDN
1160 1170 1180
EIEMADVDDE DAAERKVDLQ QKSAPESQKE TTD
Length:1,183
Mass (Da):133,039
Last modified:February 15, 2005 - v1
Checksum:iBEFE7454FFF67857
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW53580.1.
RefSeqiWP_001833083.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW53580; AAW53580; SERP0183.
KEGGiser:SERP0183.
PATRICi19611255. VBIStaEpi130894_0174.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW53580.1.
RefSeqiWP_001833083.1. NC_002976.3.

3D structure databases

ProteinModelPortaliQ5HRL0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176279.SERP0183.

Proteomic databases

PRIDEiQ5HRL0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW53580; AAW53580; SERP0183.
KEGGiser:SERP0183.
PATRICi19611255. VBIStaEpi130894_0174.

Phylogenomic databases

eggNOGiENOG4108IIJ. Bacteria.
COG0085. LUCA.
HOGENOMiHOG000218611.
KOiK03043.
OMAiYFNPKRY.
OrthoDBiEOG6M9DS6.

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-203-MONOMER.

Family and domain databases

Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB.
InterProiIPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR010243. RNA_pol_bsu_bac.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 3 hits.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62A.

Entry informationi

Entry nameiRPOB_STAEQ
AccessioniPrimary (citable) accession number: Q5HRL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 15, 2005
Last modified: July 6, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.