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Q5HRI4

- ARSC1_STAEQ

UniProt

Q5HRI4 - ARSC1_STAEQ

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Protein

Protein ArsC 1

Gene

arsC1

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.UniRule annotation

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101Nucleophile; for reductase activity and phosphatase activityUniRule annotation
Active sitei82 – 821Nucleophile; for reductase activityUniRule annotation
Active sitei89 – 891Nucleophile; for reductase activityUniRule annotation

GO - Molecular functioni

  1. arsenate reductase (thioredoxin) activity Source: UniProtKB-HAMAP
  2. protein tyrosine phosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. response to arsenic-containing substance Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Oxidoreductase

Keywords - Biological processi

Arsenical resistance

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-229-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ArsC 1UniRule annotation
Alternative name(s):
Arsenate reductase 1UniRule annotation (EC:1.20.4.-UniRule annotation)
Arsenical pump modifier 1UniRule annotation
Low molecular weight protein-tyrosine-phosphatase 1UniRule annotation (EC:3.1.3.48UniRule annotation)
Gene namesi
Name:arsC1UniRule annotation
Ordered Locus Names:SERP0209
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000531: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 132132Protein ArsC 1PRO_0000162528Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi10 ↔ 82Redox-active; alternateUniRule annotation
Disulfide bondi82 ↔ 89Redox-active; alternateUniRule annotation

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi176279.SERP0209.

Structurei

3D structure databases

ProteinModelPortaliQ5HRI4.
SMRiQ5HRI4. Positions 1-131.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.UniRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiCOG0394.
HOGENOMiHOG000273093.
KOiK03741.
OMAiSANEACP.
OrthoDBiEOG6JDWJC.

Family and domain databases

HAMAPiMF_01624. Arsenate_reduct.
InterProiIPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF18. PTHR11717:SF18. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HRI4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQKKTIYFIC TGNSCRSQMA EGFGKLILGD KWNVYSAGIE THGVNPHAIK
60 70 80 90 100
AMKEVGIDIS HHTSDLINND ILIASDIVVT LCSDADANCP VLPKNVTKEH
110 120 130
WGFDDPAGKD WSEFQRVRDE IKAAIETFAH RV
Length:132
Mass (Da):14,658
Last modified:February 15, 2005 - v1
Checksum:i89634C648FBC115F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW53573.1.
RefSeqiYP_187805.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW53573; AAW53573; SERP0209.
GeneIDi3242989.
KEGGiser:SERP0209.
PATRICi19611307. VBIStaEpi130894_0200.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW53573.1 .
RefSeqi YP_187805.1. NC_002976.3.

3D structure databases

ProteinModelPortali Q5HRI4.
SMRi Q5HRI4. Positions 1-131.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176279.SERP0209.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW53573 ; AAW53573 ; SERP0209 .
GeneIDi 3242989.
KEGGi ser:SERP0209.
PATRICi 19611307. VBIStaEpi130894_0200.

Phylogenomic databases

eggNOGi COG0394.
HOGENOMi HOG000273093.
KOi K03741.
OMAi SANEACP.
OrthoDBi EOG6JDWJC.

Enzyme and pathway databases

BioCyci SEPI176279:GJJB-229-MONOMER.

Family and domain databases

HAMAPi MF_01624. Arsenate_reduct.
InterProi IPR014064. Arsenate_reductase_ArsC.
IPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view ]
PANTHERi PTHR11717:SF18. PTHR11717:SF18. 1 hit.
Pfami PF01451. LMWPc. 1 hit.
[Graphical view ]
SMARTi SM00226. LMWPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52788. SSF52788. 1 hit.
TIGRFAMsi TIGR02691. arsC_pI258_fam. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62A.

Entry informationi

Entry nameiARSC1_STAEQ
AccessioniPrimary (citable) accession number: Q5HRI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: February 15, 2005
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3