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Protein

Putative pyridoxine kinase

Gene

pdxK

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxal, pyridoxine, and pyridoxamine as substrates (By similarity).By similarity

Catalytic activityi

ATP + pyridoxal = ADP + pyridoxal 5'-phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei139 – 1391ATPBy similarity
Metal bindingi142 – 1421MagnesiumBy similarity
Binding sitei188 – 1881ATPBy similarity
Binding sitei213 – 2131ATP; via amide nitrogenBy similarity
Binding sitei238 – 2381ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi176 – 1805ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-246-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative pyridoxine kinase (EC:2.7.1.35)
Alternative name(s):
PN/PL/PM kinase
Pyridoxal kinase
Pyridoxamine kinase
Vitamin B6 kinase
Gene namesi
Name:pdxK
Ordered Locus Names:SERP0226
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000531 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Putative pyridoxine kinasePRO_0000192034Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP0226.

Structurei

3D structure databases

ProteinModelPortaliQ5HRG7.
SMRiQ5HRG7. Positions 3-265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ThiD family.Curated

Phylogenomic databases

eggNOGiENOG4105DWF. Bacteria.
COG0351. LUCA.
HOGENOMiHOG000225273.
KOiK00868.
OMAiRIEQINV.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HRG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALKKVLTIA GSDTSAGAGM QADLKTFQEL DVYGMVALTS IVTMDKETWS
60 70 80 90 100
HDVTPIDMNI FEKQLETAIS IGPNAIKTGM LGTQDIIKRA GDVFVESGAD
110 120 130 140 150
YFVVDPVMVC KGEDEVLNPG NTEAMIQYLL PKATVVTPNL FEAGQLSGLG
160 170 180 190 200
KLTSIEDMKK AAQVIYDKGT PHVIIKGGKA LDQDKSYDLY YDGQQFYQLT
210 220 230 240 250
TDMFQQSYNH GAGCTFAAAT TAYLANGKSP KEAIIAAKAF VASAIKNGWK
260 270
MNDFVGPVDH GAYNRIEQIN VEVTEV
Length:276
Mass (Da):29,858
Last modified:December 20, 2005 - v2
Checksum:iC34AA1C9DF7D8C61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW53606.1.
RefSeqiWP_032603372.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW53606; AAW53606; SERP0226.
KEGGiser:SERP0226.
PATRICi19611341. VBIStaEpi130894_0217.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW53606.1.
RefSeqiWP_032603372.1. NC_002976.3.

3D structure databases

ProteinModelPortaliQ5HRG7.
SMRiQ5HRG7. Positions 3-265.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176279.SERP0226.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW53606; AAW53606; SERP0226.
KEGGiser:SERP0226.
PATRICi19611341. VBIStaEpi130894_0217.

Phylogenomic databases

eggNOGiENOG4105DWF. Bacteria.
COG0351. LUCA.
HOGENOMiHOG000225273.
KOiK00868.
OMAiRIEQINV.

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-246-MONOMER.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
InterProiIPR004399. HMP/HMP-P_kinase.
IPR013749. PM/HMP-P_kinase-1.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF08543. Phos_pyr_kin. 1 hit.
[Graphical view]
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00097. HMP-P_kinase. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPDXK_STAEQ
AccessioniPrimary (citable) accession number: Q5HRG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: September 7, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.