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Q5HR54 (UPPP_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA
Ordered Locus Names:SERP0339
OrganismStaphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]
Taxonomic identifier176279 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length290 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 290290Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151206

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane48 – 6821Helical; Potential
Transmembrane101 – 12121Helical; Potential
Transmembrane125 – 14521Helical; Potential
Transmembrane161 – 18121Helical; Potential
Transmembrane202 – 22221Helical; Potential
Transmembrane231 – 25121Helical; Potential
Transmembrane266 – 28621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q5HR54 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 31C2CDFEFDDE7292

FASTA29032,212
        10         20         30         40         50         60 
MFLLELIKGI ILGIVEGLTE FAPVSSTGHM ILVDDMWLKS TNFLGSQSAF TFKVVIQLGS 

        70         80         90        100        110        120 
VFAAAWVFRE RFLEILHIGQ HKPEPSTSGD RRSKPRRLNL IHVLVGMVPA GILGFLFDDL 

       130        140        150        160        170        180 
IEKYLFSVPT VLIGLFIGAI YMIIADKYSK TVQHPQTVDQ INYFQAFVIG ISQAIAMWPG 

       190        200        210        220        230        240 
FSRSGSTIST GVLMKLNHKA ASDFTFIMSV PIMLAASGLS LLKHYEYIHL AHIPFYILGF 

       250        260        270        280        290 
LAAFIVGLIA IKTFLHLINK VKLVPFAIYR IVLVIFIAIL YFGFGIGKGI 

« Hide

References

[1]"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. expand/collapse author list , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000029 Genomic DNA. Translation: AAW53717.1.
RefSeqYP_187935.1. NC_002976.3.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176279.SERP0339.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW53717; AAW53717; SERP0339.
GeneID3240659.
KEGGser:SERP0339.
PATRIC19611553. VBIStaEpi130894_0323.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycSEPI176279:GJJB-359-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_STAEQ
AccessionPrimary (citable) accession number: Q5HR54
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families