Q5HR08 (HIS8_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase
EC=2.6.1.9

Alternative name(s):
Imidazole acetol-phosphate transaminase

Gene names

Name:	hisC
Ordered Locus Names:	SERP0387

Organism

Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]

Taxonomic identifier

176279 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP MF_01023
Cofactor	Pyridoxal phosphate By similarity. HAMAP MF_01023
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP MF_01023
Subunit structure	Homodimer By similarity. HAMAP MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	histidine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 351	351	Histidinol-phosphate aminotransferase HAMAP MF_01023		PRO_0000153458
Amino acid modifications
	Modified residue	221	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5HR08 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 95C1CC1A623C8189	FASTA	351	39,655
	10 20 30 40 50 60 MKKQLDQLTA YTPGLSPESL KKQYGIKGEL HKLASNENVY GPSPKVKTAI QSHLDELYYY 70 80 90 100 110 120 PESGSPKLRE AISQQLNVDA SRILFGAGLD EVILMISRAV LSPGDKIITS ESTFGQYYHN 130 140 150 160 170 180 AIVESADVIQ VPLKDGGFDL DGMLQQIDNK TSLIWLCNPN NPTGTYFSHD ELFNFLKRVP 190 200 210 220 230 240 SDIPVLIDEA YVEFVTADDF PDTLKLQEDF DNAFLLRTFS KAYGLAGLRV GYVIASEDAI 250 260 270 280 290 300 EKWNIIRPPF NVTRISEYAA IAALEDQEYL KEVTQKNSFE RDKFYQIPQS QHFLPSQANF 310 320 330 340 350 VFVKTSRSQA LYDALLNVGC ITRLFPNGVR ITIGLPEQNN KMIEVLKHFE Y

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000029 Genomic DNA. Translation: AAW53768.1.
RefSeq	YP_187981.1. NC_002976.3.
3D structure databases
ProteinModelPortal	Q5HR08.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HR08.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000043524; EBSTAP00000042067; EBSTAG00000043522.
GeneID	3241321.
GenomeReviews	Gene locus SERP0387 in contig CP000029_GR.
KEGG	ser:SERP0387.
NMPDR	fig|176279.3.peg.821.
PATRIC	19611645. VBIStaEpi130894_0369.
TIGR	SERP0387.
Phylogenomic databases
eggNOG	COG0079.
GeneTree	EBGT00050000024045.
HOGENOM	HBG646350.
OMA	GLANFRI.
PhylomeDB	Q5HR08.
ProtClustDB	PRK03158.
Enzyme and pathway databases
BioCyc	SEPI176279:SERP0387-MONOMER.
Family and domain databases
HAMAP	MF_01023. HisC_aminotrans_2. [Tree]
InterPro	IPR001917. Aminotrans_II_pyridoxalP_BS. IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
KO	K00817.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. HisC. 1 hit.
PROSITE	PS00599. AA_TRANSFER_CLASS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HIS8_STAEQ

Accession

Primary (citable) accession number: Q5HR08

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	February 15, 2005
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program