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Q5HQX0

- UVRB_STAEQ

UniProt

Q5HQX0 - UVRB_STAEQ

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Protein
UvrABC system protein B
Gene
uvrB, SERP0426
Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi41 – 488ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-HAMAP
  3. excinuclease ABC activity Source: UniProtKB-HAMAP
  4. helicase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. SOS response Source: UniProtKB-HAMAP
  2. nucleotide-excision repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Excision nuclease

Keywords - Biological processi

DNA damage, DNA excision, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-447-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein B
Short name:
Protein UvrB
Alternative name(s):
Excinuclease ABC subunit B
Gene namesi
Name:uvrB
Ordered Locus Names:SERP0426
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000531: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 661661UvrABC system protein BUniRule annotation
PRO_0000138431Add
BLAST

Proteomic databases

PRIDEiQ5HQX0.

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex By similarity.

Protein-protein interaction databases

STRINGi176279.SERP0426.

Structurei

3D structure databases

ProteinModelPortaliQ5HQX0.
SMRiQ5HQX0. Positions 7-654.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 414387Helicase ATP-binding
Add
BLAST
Domaini432 – 598167Helicase C-terminal
Add
BLAST
Domaini625 – 66036UVR
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi94 – 11724Beta-hairpinUniRule annotation
Add
BLAST

Domaini

The beta-hairpin motif is involved in DNA binding By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.
Contains 1 UVR domain.

Phylogenomic databases

eggNOGiCOG0556.
HOGENOMiHOG000073580.
KOiK03702.
OMAiLEKQMHE.
OrthoDBiEOG6B360R.

Family and domain databases

Gene3Di3.40.50.300. 4 hits.
4.10.860.10. 1 hit.
HAMAPiMF_00204. UvrB.
InterProiIPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view]
PANTHERiPTHR24029. PTHR24029. 1 hit.
PfamiPF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00631. uvrb. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HQX0-1 [UniParc]FASTAAdd to Basket

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MVEHVPFKLK SEFEPQGDQP QAIQKIVDGV NEGKRHQTLL GATGTGKTFT    50
MSNVIKEVGK PTLIIAHNKT LAGQLYSEFK EFFPENRVEY FVSYYDYYQP 100
EAYVPSTDTF IEKDASINDE IDQLRHSATS SLFERDDVII IASVSCIYGL 150
GNPEEYKNLV VSVRVGMEME RSELLRKLVD VQYSRNDIDF QRGTFRVRGD 200
VVEIFPASRE EMCIRVEFFG DEIDRIREVN YLTGEVIRER EHFTIFPASH 250
FVTREEKMKV AIERIEKELE ERLKELRDEN KLLEAQRLEQ RTNYDLEMMR 300
EMGFCSGIEN YSVHLTLRPL GSTPYTLLDY FGDDWLVMID ESHVTLPQIR 350
GMYNGDRARK QVLIDHGFRL PSALDNRPLK FEEFEEKTKQ LVYVSATPGP 400
YELEHTDEMV EQIIRPTGLL DPKIDVRPTE NQIDDLLSEI QDRVDKDERV 450
LVTTLTKKMS EDLTTYMKEA GIKVNYLHSE IKTLERIEII RDLRMGTYDA 500
IVGINLLREG IDIPEVSLVV ILDADKEGFL RSDRSLIQTI GRAARNDKGE 550
VIMYADKITD SMQYAIDETQ RRREIQIAHN KEHGITPKTI NKKIHDVISA 600
TVESDETNQQ QQTELPKKMT KKERQKTIEN IEKEMKKAAK DLDFEKATEL 650
RDMLFELKAE G 661
Length:661
Mass (Da):76,669
Last modified:February 15, 2005 - v1
Checksum:i342D968A43FA1112
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW53840.1.
RefSeqiYP_188019.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW53840; AAW53840; SERP0426.
GeneIDi3240773.
KEGGiser:SERP0426.
PATRICi19611717. VBIStaEpi130894_0405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW53840.1 .
RefSeqi YP_188019.1. NC_002976.3.

3D structure databases

ProteinModelPortali Q5HQX0.
SMRi Q5HQX0. Positions 7-654.
ModBasei Search...

Protein-protein interaction databases

STRINGi 176279.SERP0426.

Proteomic databases

PRIDEi Q5HQX0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW53840 ; AAW53840 ; SERP0426 .
GeneIDi 3240773.
KEGGi ser:SERP0426.
PATRICi 19611717. VBIStaEpi130894_0405.

Phylogenomic databases

eggNOGi COG0556.
HOGENOMi HOG000073580.
KOi K03702.
OMAi LEKQMHE.
OrthoDBi EOG6B360R.

Enzyme and pathway databases

BioCyci SEPI176279:GJJB-447-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 4 hits.
4.10.860.10. 1 hit.
HAMAPi MF_00204. UvrB.
InterProi IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
[Graphical view ]
PANTHERi PTHR24029. PTHR24029. 1 hit.
Pfami PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsi TIGR00631. uvrb. 1 hit.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62A.

Entry informationi

Entry nameiUVRB_STAEQ
AccessioniPrimary (citable) accession number: Q5HQX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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