Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5HQX0

- UVRB_STAEQ

UniProt

Q5HQX0 - UVRB_STAEQ

Protein

UvrABC system protein B

Gene

uvrB

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi41 – 488ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: UniProtKB-HAMAP
    3. excinuclease ABC activity Source: UniProtKB-HAMAP
    4. helicase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. nucleotide-excision repair Source: UniProtKB-HAMAP
    2. SOS response Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Excision nuclease

    Keywords - Biological processi

    DNA damage, DNA excision, DNA repair, SOS response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSEPI176279:GJJB-447-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    UvrABC system protein BUniRule annotation
    Short name:
    Protein UvrBUniRule annotation
    Alternative name(s):
    Excinuclease ABC subunit BUniRule annotation
    Gene namesi
    Name:uvrBUniRule annotation
    Ordered Locus Names:SERP0426
    OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
    Taxonomic identifieri176279 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000531: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 661661UvrABC system protein BPRO_0000138431Add
    BLAST

    Proteomic databases

    PRIDEiQ5HQX0.

    Interactioni

    Subunit structurei

    Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi176279.SERP0426.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5HQX0.
    SMRiQ5HQX0. Positions 7-654.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 414387Helicase ATP-bindingUniRule annotationAdd
    BLAST
    Domaini432 – 598167Helicase C-terminalUniRule annotationAdd
    BLAST
    Domaini625 – 66036UVRUniRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi94 – 11724Beta-hairpinAdd
    BLAST

    Domaini

    The beta-hairpin motif is involved in DNA binding.UniRule annotation

    Sequence similaritiesi

    Belongs to the UvrB family.UniRule annotation
    Contains 1 helicase ATP-binding domain.UniRule annotation
    Contains 1 helicase C-terminal domain.UniRule annotation
    Contains 1 UVR domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0556.
    HOGENOMiHOG000073580.
    KOiK03702.
    OMAiLEKQMHE.
    OrthoDBiEOG6B360R.

    Family and domain databases

    Gene3Di3.40.50.300. 4 hits.
    4.10.860.10. 1 hit.
    HAMAPiMF_00204. UvrB.
    InterProiIPR006935. Helicase/UvrB_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR001943. UVR_dom.
    IPR004807. UvrB.
    IPR024759. UvrB_YAD/RRR_dom.
    [Graphical view]
    PANTHERiPTHR24029. PTHR24029. 1 hit.
    PfamiPF00271. Helicase_C. 1 hit.
    PF04851. ResIII. 1 hit.
    PF02151. UVR. 1 hit.
    PF12344. UvrB. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF46600. SSF46600. 1 hit.
    SSF52540. SSF52540. 3 hits.
    TIGRFAMsiTIGR00631. uvrb. 1 hit.
    PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50151. UVR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5HQX0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVEHVPFKLK SEFEPQGDQP QAIQKIVDGV NEGKRHQTLL GATGTGKTFT    50
    MSNVIKEVGK PTLIIAHNKT LAGQLYSEFK EFFPENRVEY FVSYYDYYQP 100
    EAYVPSTDTF IEKDASINDE IDQLRHSATS SLFERDDVII IASVSCIYGL 150
    GNPEEYKNLV VSVRVGMEME RSELLRKLVD VQYSRNDIDF QRGTFRVRGD 200
    VVEIFPASRE EMCIRVEFFG DEIDRIREVN YLTGEVIRER EHFTIFPASH 250
    FVTREEKMKV AIERIEKELE ERLKELRDEN KLLEAQRLEQ RTNYDLEMMR 300
    EMGFCSGIEN YSVHLTLRPL GSTPYTLLDY FGDDWLVMID ESHVTLPQIR 350
    GMYNGDRARK QVLIDHGFRL PSALDNRPLK FEEFEEKTKQ LVYVSATPGP 400
    YELEHTDEMV EQIIRPTGLL DPKIDVRPTE NQIDDLLSEI QDRVDKDERV 450
    LVTTLTKKMS EDLTTYMKEA GIKVNYLHSE IKTLERIEII RDLRMGTYDA 500
    IVGINLLREG IDIPEVSLVV ILDADKEGFL RSDRSLIQTI GRAARNDKGE 550
    VIMYADKITD SMQYAIDETQ RRREIQIAHN KEHGITPKTI NKKIHDVISA 600
    TVESDETNQQ QQTELPKKMT KKERQKTIEN IEKEMKKAAK DLDFEKATEL 650
    RDMLFELKAE G 661
    Length:661
    Mass (Da):76,669
    Last modified:February 15, 2005 - v1
    Checksum:i342D968A43FA1112
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000029 Genomic DNA. Translation: AAW53840.1.
    RefSeqiYP_188019.1. NC_002976.3.

    Genome annotation databases

    EnsemblBacteriaiAAW53840; AAW53840; SERP0426.
    GeneIDi3240773.
    KEGGiser:SERP0426.
    PATRICi19611717. VBIStaEpi130894_0405.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000029 Genomic DNA. Translation: AAW53840.1 .
    RefSeqi YP_188019.1. NC_002976.3.

    3D structure databases

    ProteinModelPortali Q5HQX0.
    SMRi Q5HQX0. Positions 7-654.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176279.SERP0426.

    Proteomic databases

    PRIDEi Q5HQX0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW53840 ; AAW53840 ; SERP0426 .
    GeneIDi 3240773.
    KEGGi ser:SERP0426.
    PATRICi 19611717. VBIStaEpi130894_0405.

    Phylogenomic databases

    eggNOGi COG0556.
    HOGENOMi HOG000073580.
    KOi K03702.
    OMAi LEKQMHE.
    OrthoDBi EOG6B360R.

    Enzyme and pathway databases

    BioCyci SEPI176279:GJJB-447-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 4 hits.
    4.10.860.10. 1 hit.
    HAMAPi MF_00204. UvrB.
    InterProi IPR006935. Helicase/UvrB_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR001943. UVR_dom.
    IPR004807. UvrB.
    IPR024759. UvrB_YAD/RRR_dom.
    [Graphical view ]
    PANTHERi PTHR24029. PTHR24029. 1 hit.
    Pfami PF00271. Helicase_C. 1 hit.
    PF04851. ResIII. 1 hit.
    PF02151. UVR. 1 hit.
    PF12344. UvrB. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46600. SSF46600. 1 hit.
    SSF52540. SSF52540. 3 hits.
    TIGRFAMsi TIGR00631. uvrb. 1 hit.
    PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50151. UVR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
      Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
      , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
      J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35984 / RP62A.

    Entry informationi

    Entry nameiUVRB_STAEQ
    AccessioniPrimary (citable) accession number: Q5HQX0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3