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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. Fructose-bisphosphate aldolase class 1 (fda), Fructose-bisphosphate aldolase (fba)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei285Proton donorUniRule annotation1
Active sitei306UniRule annotation1
Active sitei420UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processGluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:SERP0550
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000531 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001807331 – 443Glucose-6-phosphate isomeraseAdd BLAST443

Proteomic databases

PRIDEiQ5HQJ9.

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP0550.

Structurei

3D structure databases

ProteinModelPortaliQ5HQJ9.
SMRiQ5HQJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QYV. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000100403.
KOiK01810.
OMAiSFIIPDD.

Family and domain databases

CDDicd05015. SIS_PGI_1. 1 hit.
cd05016. SIS_PGI_2. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiView protein in InterPro
IPR001672. G6P_Isomerase.
IPR018189. Phosphoglucose_isomerase_CS.
IPR035476. SIS_PGI_1.
IPR035482. SIS_PGI_2.
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiView protein in Pfam
PF00342. PGI. 1 hit.
PRINTSiPR00662. G6PISOMERASE.
PROSITEiView protein in PROSITE
PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HQJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHIQLDYGK TLEFFDKHEL DQQKDIVKTI HQTIHKGTGA GNDFLGWLDL
60 70 80 90 100
PVDYDKEEFS RIVEASKRIK SNSDVLVVIG IGGSYLGARA AIEMLTSSFR
110 120 130 140 150
TNTEYPEIVF VGNHLSSSYT KELLDYLQGK DFSVNVISKS GTTTEPAVAF
160 170 180 190 200
RLFKQLVEEK YGKDEAKKRI FATTDKSKGA LKQLADNEGY ETFVVPDDVG
210 220 230 240 250
GRYSVLTAVG LLPIATAGIN IESIMIGAAK AREELSSDDL DQNIAYQYAT
260 270 280 290 300
IRNILYSKGY TTEMLINYEP SMQYFNEWWK QLYGESEGKD FKGIYPSSAN
310 320 330 340 350
YTTDLHSLGQ YVQEGRRFLF ETVVKVNHPK HDIKIEEDAD DLDGLNYLAG
360 370 380 390 400
KSIDEVNTKA FEGTLLAHTD GGVPNIVVNI PQLDEETFGY VVYFFELACA
410 420 430 440
MSGYQLGVNP FNQPGVEAYK QNMFALLGKP GFEDKKKELE NRL
Length:443
Mass (Da):49,708
Last modified:February 15, 2005 - v1
Checksum:i7FC5A79606E5A5D7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW53921.1.
RefSeqiWP_001831993.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW53921; AAW53921; SERP0550.
KEGGiser:SERP0550.

Similar proteinsi

Entry informationi

Entry nameiG6PI_STAEQ
AccessioniPrimary (citable) accession number: Q5HQJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: February 15, 2005
Last modified: August 30, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families