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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei133L-tryptophanUniRule annotation1
Binding sitei184ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 11ATPUniRule annotation3
Nucleotide bindingi17 – 18ATPUniRule annotation2
Nucleotide bindingi145 – 147ATPUniRule annotation3
Nucleotide bindingi193 – 197ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:SERP0575
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000531 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366821 – 329Tryptophan--tRNA ligaseAdd BLAST329

Proteomic databases

PRIDEiQ5HQH4

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi176279.SERP0575

Structurei

3D structure databases

ProteinModelPortaliQ5HQH4
SMRiQ5HQH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 18"HIGH" regionUniRule annotation9
Motifi193 – 197"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059940
KOiK01867
OMAiQRMTQFK

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HQH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METLFSGIQP SGIPTIGNYI GALKQFVDVQ DDYECFFCIV DQHAITVPQD
60 70 80 90 100
RLKLRKQIRQ LAAIYLASGI DPDKSTLFIQ SEVPAHVQAG WMLTTIASIG
110 120 130 140 150
ELERMTQFKD KAQKRADGVP AGLLTYPPLM AADIVIYNTN IVPVGDDQKQ
160 170 180 190 200
HMELTRNLVD RFNSRYNDVL VKPEVRMPKV GGRVMSLQDP TKKMSKSDDN
210 220 230 240 250
QKNFISLLDE PHVAAKKIKS AVTDSDGIIK FDRENKPGIS NLLSIYSGLT
260 270 280 290 300
NDSIKNIESK YEGEGYGKFK GDLSEIVKDF LINFQEKYAS FYNSDDLDDI
310 320
LDKGKEKAQK ASFKTLKKME KAMGLGRKR
Length:329
Mass (Da):36,942
Last modified:February 15, 2005 - v1
Checksum:i26956E99EBC8C743
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA Translation: AAW53977.1
RefSeqiWP_002446070.1, NC_002976.3

Genome annotation databases

EnsemblBacteriaiAAW53977; AAW53977; SERP0575
KEGGiser:SERP0575

Similar proteinsi

Entry informationi

Entry nameiSYW_STAEQ
AccessioniPrimary (citable) accession number: Q5HQH4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health