Q5HQG2 (PPNK_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	SERP0587

Organism

Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]

Taxonomic identifier

176279 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	269 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 269	269	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_0000120665

Sequences

	Sequence		Length	Mass (Da)
	Q5HQG2 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 159FBA460D5392EB	FASTA	269	30,603
	10 20 30 40 50 60 MRYTILTKGD SKSNALKHKM INHMKDFQMV EDSENPEIVI SVGGDGTLLQ AFHQYSHMLS 70 80 90 100 110 120 KVAFVGIHTG HLGFYADWLP HEVEKLIIEI NNSEFQVIEY PLLELIVRYN DNGYETRYLA 130 140 150 160 170 180 LNEATMKTEN GSTLVVDVNI RGKHFERFRG DGLCISTPSG STAYNKALGG ALIHPSLEAM 190 200 210 220 230 240 QIAEIASINN RVFRTVGSPL VLPKHHTCLI TPVNHDTIRT TIDHVSIKHK NVNAIQYRVA 250 260 NEKVRFARFR PFPFWKRVHD SFISSDDER

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000029 Genomic DNA. Translation: AAW54002.1.
RefSeq	YP_188178.1. NC_002976.3.
3D structure databases
ProteinModelPortal	Q5HQG2.
SMR	Q5HQG2. Positions 1-263.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HQG2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000042762; EBSTAP00000041305; EBSTAG00000042760.
GeneID	3240496.
GenomeReviews	Gene locus SERP0587 in contig CP000029_GR.
KEGG	ser:SERP0587.
PATRIC	19612043. VBIStaEpi130894_0567.
TIGR	SERP0587.
Phylogenomic databases
eggNOG	COG0061.
GeneTree	EBGT00050000025514.
HOGENOM	HBG314020.
OMA	TISFANC.
PhylomeDB	Q5HQG2.
ProtClustDB	PRK04885.
Enzyme and pathway databases
BioCyc	SEPI176279:SERP0587-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_STAEQ

Accession

Primary (citable) accession number: Q5HQG2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	February 15, 2005
Last modified:	January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program