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Q5HQ76

- ODPA_STAEQ

UniProt

Q5HQ76 - ODPA_STAEQ

Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.By similarity

    Catalytic activityi

    Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

    Cofactori

    Thiamine pyrophosphate.By similarity

    GO - Molecular functioni

    1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC
    2. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    Pyruvate, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciSEPI176279:GJJB-705-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
    Gene namesi
    Name:pdhA
    Ordered Locus Names:SERP0680
    OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
    Taxonomic identifieri176279 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000531: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 370370Pyruvate dehydrogenase E1 component subunit alphaPRO_0000162212Add
    BLAST

    Proteomic databases

    PRIDEiQ5HQ76.

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta chain.

    Protein-protein interaction databases

    STRINGi176279.SERP0680.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5HQ76.
    SMRiQ5HQ76. Positions 8-370.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiCOG1071.
    HOGENOMiHOG000281335.
    KOiK00161.
    OMAiNNGYAIT.
    OrthoDBiEOG6VMTKR.

    Family and domain databases

    Gene3Di3.40.50.970. 1 hit.
    InterProiIPR001017. DH_E1.
    IPR017596. PdhA/BkdA.
    IPR029061. THDP-binding.
    [Graphical view]
    PfamiPF00676. E1_dh. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 1 hit.
    TIGRFAMsiTIGR03181. PDH_E1_alph_x. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5HQ76-1 [UniParc]FASTAAdd to Basket

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    MAPKLQAQFD AVKVLNETQS KFEMVQILDE DGNVVNEDLV PDLTDEQLVE    50
    LMERMVWTRI LDQRSISLNR QGRLGFYAPT AGQEASQLAS QYALESEDFI 100
    LPGYRDVPQI IWHGLPLTDA FLFSRGHFKG NQFPEGVNAL SPQIIIGAQY 150
    IQTAGVAFGL KKRGKNAVAI TYTGDGGSSQ GDFYEGINFA SAYKAPAIFV 200
    IQNNNYAIST PRSKQTAAET LAQKAISVGI PGIQVDGMDA LAVYQATLEA 250
    RERAVAGEGP TVIETLTYRY GPHTMAGDDP TRYRTSDEDA EWEKKDPLVR 300
    FRKYLEAKGL WNEDKENEVV ERAKSEIKAA IKEADNTEKQ TVTSLMDIMY 350
    EEMPQNLAEQ YEIYKEKESK 370
    Length:370
    Mass (Da):41,330
    Last modified:February 15, 2005 - v1
    Checksum:iF691D1D8C2E3EEB4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000029 Genomic DNA. Translation: AAW54052.1.
    RefSeqiYP_188264.1. NC_002976.3.

    Genome annotation databases

    EnsemblBacteriaiAAW54052; AAW54052; SERP0680.
    GeneIDi3240395.
    KEGGiser:SERP0680.
    PATRICi19612229. VBIStaEpi130894_0658.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000029 Genomic DNA. Translation: AAW54052.1 .
    RefSeqi YP_188264.1. NC_002976.3.

    3D structure databases

    ProteinModelPortali Q5HQ76.
    SMRi Q5HQ76. Positions 8-370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176279.SERP0680.

    Proteomic databases

    PRIDEi Q5HQ76.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW54052 ; AAW54052 ; SERP0680 .
    GeneIDi 3240395.
    KEGGi ser:SERP0680.
    PATRICi 19612229. VBIStaEpi130894_0658.

    Phylogenomic databases

    eggNOGi COG1071.
    HOGENOMi HOG000281335.
    KOi K00161.
    OMAi NNGYAIT.
    OrthoDBi EOG6VMTKR.

    Enzyme and pathway databases

    BioCyci SEPI176279:GJJB-705-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.970. 1 hit.
    InterProi IPR001017. DH_E1.
    IPR017596. PdhA/BkdA.
    IPR029061. THDP-binding.
    [Graphical view ]
    Pfami PF00676. E1_dh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 1 hit.
    TIGRFAMsi TIGR03181. PDH_E1_alph_x. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
      Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
      , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
      J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35984 / RP62A.

    Entry informationi

    Entry nameiODPA_STAEQ
    AccessioniPrimary (citable) accession number: Q5HQ76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    External Data

    Dasty 3