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Protein

Pyruvate dehydrogenase E1 component subunit alpha

Gene

pdhA

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).By similarity

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-705-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit alpha (EC:1.2.4.1)
Gene namesi
Name:pdhA
Ordered Locus Names:SERP0680
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000531: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Pyruvate dehydrogenase E1 component subunit alphaPRO_0000162212Add
BLAST

Proteomic databases

PRIDEiQ5HQ76.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

STRINGi176279.SERP0680.

Structurei

3D structure databases

ProteinModelPortaliQ5HQ76.
SMRiQ5HQ76. Positions 8-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiCOG1071.
HOGENOMiHOG000281335.
KOiK00161.
OMAiDFYEAMN.
OrthoDBiEOG6VMTKR.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017596. PdhA/BkdA.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03181. PDH_E1_alph_x. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HQ76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKLQAQFD AVKVLNETQS KFEMVQILDE DGNVVNEDLV PDLTDEQLVE
60 70 80 90 100
LMERMVWTRI LDQRSISLNR QGRLGFYAPT AGQEASQLAS QYALESEDFI
110 120 130 140 150
LPGYRDVPQI IWHGLPLTDA FLFSRGHFKG NQFPEGVNAL SPQIIIGAQY
160 170 180 190 200
IQTAGVAFGL KKRGKNAVAI TYTGDGGSSQ GDFYEGINFA SAYKAPAIFV
210 220 230 240 250
IQNNNYAIST PRSKQTAAET LAQKAISVGI PGIQVDGMDA LAVYQATLEA
260 270 280 290 300
RERAVAGEGP TVIETLTYRY GPHTMAGDDP TRYRTSDEDA EWEKKDPLVR
310 320 330 340 350
FRKYLEAKGL WNEDKENEVV ERAKSEIKAA IKEADNTEKQ TVTSLMDIMY
360 370
EEMPQNLAEQ YEIYKEKESK
Length:370
Mass (Da):41,330
Last modified:February 15, 2005 - v1
Checksum:iF691D1D8C2E3EEB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW54052.1.
RefSeqiYP_188264.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW54052; AAW54052; SERP0680.
GeneIDi3240395.
KEGGiser:SERP0680.
PATRICi19612229. VBIStaEpi130894_0658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW54052.1.
RefSeqiYP_188264.1. NC_002976.3.

3D structure databases

ProteinModelPortaliQ5HQ76.
SMRiQ5HQ76. Positions 8-370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176279.SERP0680.

Proteomic databases

PRIDEiQ5HQ76.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW54052; AAW54052; SERP0680.
GeneIDi3240395.
KEGGiser:SERP0680.
PATRICi19612229. VBIStaEpi130894_0658.

Phylogenomic databases

eggNOGiCOG1071.
HOGENOMiHOG000281335.
KOiK00161.
OMAiDFYEAMN.
OrthoDBiEOG6VMTKR.

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-705-MONOMER.

Family and domain databases

Gene3Di3.40.50.970. 1 hit.
InterProiIPR001017. DH_E1.
IPR017596. PdhA/BkdA.
IPR029061. THDP-binding.
[Graphical view]
PfamiPF00676. E1_dh. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
TIGRFAMsiTIGR03181. PDH_E1_alph_x. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62A.

Entry informationi

Entry nameiODPA_STAEQ
AccessioniPrimary (citable) accession number: Q5HQ76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: February 15, 2005
Last modified: March 4, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.