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Q5HQ75

- ODPB_STAEQ

UniProt

Q5HQ75 - ODPB_STAEQ

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Protein
Pyruvate dehydrogenase E1 component subunit beta
Gene
pdhB, SERP0681
Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.

Cofactori

Thiamine pyrophosphate By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei60 – 601Thiamine pyrophosphate By similarity

GO - Molecular functioni

  1. pyruvate dehydrogenase (acetyl-transferring) activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Pyruvate, Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-706-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit beta (EC:1.2.4.1)
Gene namesi
Name:pdhB
Ordered Locus Names:SERP0681
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000531: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Pyruvate dehydrogenase E1 component subunit beta
PRO_0000162236Add
BLAST

Proteomic databases

PRIDEiQ5HQ75.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.

Protein-protein interaction databases

STRINGi176279.SERP0681.

Structurei

3D structure databases

ProteinModelPortaliQ5HQ75.
SMRiQ5HQ75. Positions 2-325.

Family & Domainsi

Phylogenomic databases

eggNOGiCOG0022.
HOGENOMiHOG000281451.
KOiK00162.
OMAiWSKHELG.
OrthoDBiEOG6JQH4C.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProiIPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
[Graphical view]
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HQ75-1 [UniParc]FASTAAdd to Basket

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MAQMTMVQAI NDALKSELKR DEDVLVFGED VGVNGGVFRV TEGLQKEFGE    50
DRVFDTPLAE SGIGGLALGL AVTGFRPVME IQFLGFVYEV FDEVAGQIAR 100
TRFRSGGTKP APVTIRTPFG GGVHTPELHA DNLEGILAQS PGLKVVIPSG 150
PYDAKGLLIS SIQSNDPVVY LEHMKLYRSF REEVPEEEYK IDIGKANVKK 200
EGNDITLISY GAMVQESLKA AEELEKDGYS VEVIDLRTVQ PIDIDTLVAS 250
VEKTGRAVVV QEAQRQAGVG AQVAAELAER AILSLEAPIA RVAASDTIYP 300
FTQAENVWLP NKKDIIEQAK ATLEF 325
Length:325
Mass (Da):35,293
Last modified:February 15, 2005 - v1
Checksum:i01A6E5FB2D9C1CCE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW54053.1.
RefSeqiYP_188265.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW54053; AAW54053; SERP0681.
GeneIDi3240396.
KEGGiser:SERP0681.
PATRICi19612231. VBIStaEpi130894_0659.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW54053.1 .
RefSeqi YP_188265.1. NC_002976.3.

3D structure databases

ProteinModelPortali Q5HQ75.
SMRi Q5HQ75. Positions 2-325.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176279.SERP0681.

Proteomic databases

PRIDEi Q5HQ75.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW54053 ; AAW54053 ; SERP0681 .
GeneIDi 3240396.
KEGGi ser:SERP0681.
PATRICi 19612231. VBIStaEpi130894_0659.

Phylogenomic databases

eggNOGi COG0022.
HOGENOMi HOG000281451.
KOi K00162.
OMAi WSKHELG.
OrthoDBi EOG6JQH4C.

Enzyme and pathway databases

BioCyci SEPI176279:GJJB-706-MONOMER.

Family and domain databases

Gene3Di 3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProi IPR029061. THDP-binding.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR005475. Transketolase-like_Pyr-bd.
IPR005476. Transketolase_C.
[Graphical view ]
Pfami PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view ]
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62A.

Entry informationi

Entry nameiODPB_STAEQ
AccessioniPrimary (citable) accession number: Q5HQ75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: February 15, 2005
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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