Q5HPY1 (KGUA_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Guanylate kinase
EC=2.7.4.8

Alternative name(s):
GMP kinase

Gene names

Name:	gmk
Ordered Locus Names:	SERP0776

Organism

Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]

Taxonomic identifier

176279 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Essential for recycling GMP and indirectly, cGMP By similarity. HAMAP MF_00328
Catalytic activity	ATP + GMP = ADP + GDP. HAMAP MF_00328
Subcellular location	Cytoplasm By similarity HAMAP MF_00328.
Sequence similarities	Belongs to the guanylate kinase family. Contains 1 guanylate kinase-like domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW guanylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Guanylate kinase HAMAP MF_00328		PRO_0000170611
Regions
	Domain	6 – 185	180	Guanylate kinase-like
	Nucleotide binding	13 – 20	8	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5HPY1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 4C70E8D681E4ACE3	FASTA	207	24,094
	10 20 30 40 50 60 MDKEKGLLIV LSGPSGVGKG TVRKKIFEDP TTSYKYSISM TTRHMREGEI DGVDYFFKTK 70 80 90 100 110 120 EEFEALIKDD QFIEYAQYVG NYYGTPVQYV KDTMEEGHDV FLEIEVEGAK QVRKKFPDAL 130 140 150 160 170 180 FIFLAPPSLD DLRERLVGRG TESDEKIQSR VNEARKEVEM MNLYDYVVVN DEVELAKNRI 190 200 QSIVEAEHLK RERIEAKYRK MLLEVKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35984 / RP62A.
[2]	"Establishment of a multilocus sequence typing system for Staphylococcus epidermidis." Anderson A.S., Wang X.-M., McClements W., Noble L., Jansen K. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-154.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000029 Genomic DNA. Translation: AAW54187.1. AY163287 Genomic DNA. Translation: AAO60566.1.
RefSeq	YP_188359.1. NC_002976.3.
3D structure databases
ProteinModelPortal	Q5HPY1.
SMR	Q5HPY1. Positions 5-206.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HPY1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000042532; EBSTAP00000041075; EBSTAG00000042530.
GeneID	3240992.
GenomeReviews	Gene locus SERP0776 in contig CP000029_GR.
KEGG	ser:SERP0776.
NMPDR	fig|176279.3.peg.838.
PATRIC	19612423. VBIStaEpi130894_0754.
TIGR	SERP0776.
Phylogenomic databases
eggNOG	COG0194.
GeneTree	EBGT00050000024543.
HOGENOM	HBG671982.
OMA	DIDWQGT.
PhylomeDB	Q5HPY1.
ProtClustDB	PRK00300.
Enzyme and pathway databases
BioCyc	SEPI176279:SERP0776-MONOMER.
Family and domain databases
HAMAP	MF_00328. Guanylate_kinase. [Tree]
InterPro	IPR008144. Guanylate_kin. IPR008145. Guanylate_kin/L-typ_Ca_channel. IPR020590. Guanylate_kinase_CS. IPR017665. Guanylate_kinase_sub. [Graphical view]
KO	K00942.
Pfam	PF00625. Guanylate_kin. 1 hit. [Graphical view]
SMART	SM00072. GuKc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03263. Guanyl_kin. 1 hit.
PROSITE	PS00856. GUANYLATE_KINASE_1. 1 hit. PS50052. GUANYLATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KGUA_STAEQ

Accession

Primary (citable) accession number: Q5HPY1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2005
Last sequence update:	February 15, 2005
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program