Q5HPQ8 (PGSA_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
EC=2.7.8.5

Alternative name(s):
Phosphatidylglycerophosphate synthase
Short name=PGP synthase

Gene names

Name:	pgsA
Ordered Locus Names:	SERP0850

Organism

Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]

Taxonomic identifier

176279 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus epidermidis

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein catalyzes the committed step to the synthesis of the acidic phospholipids By similarity.
Catalytic activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-I family.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Phospholipid biosynthesis Phospholipid metabolism
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	phosphatidylglycerol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 193	193	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase		PRO_0000056791
Regions
	Transmembrane	7 – 29	23	Helical; Potential
	Transmembrane	44 – 63	20	Helical; Potential
	Transmembrane	84 – 106	23	Helical; Potential
	Transmembrane	129 – 151	23	Helical; Potential
	Transmembrane	157 – 179	23	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5HPQ8 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: B59344586D41B319	FASTA	193	21,497
	10 20 30 40 50 60 MNIPNQITVF RVILIPFFIL FALVDFGFGQ ISILGGNHIR IEILISAIIF VVASLSDFAD 70 80 90 100 110 120 GYLARKWQLV TNMGKFLDPL ADKLLVASAL IVMVQLGFTN SVVAIIIIAR EFAVTGLRLL 130 140 150 160 170 180 QIEQGFVSAA GQLGKIKTAV TMVAIIWILL GDPFVHYLRF PIGVWLLYIG VFFTILSGIE 190 YFYKGRDVFK HSK

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000029 Genomic DNA. Translation: AAW54227.1.
RefSeq	YP_188432.1. NC_002976.3.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	176279.SERP0850.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAW54227; AAW54227; SERP0850.
GeneID	3242631.
KEGG	ser:SERP0850.
PATRIC	19612573. VBIStaEpi130894_0829.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0558.
HOGENOM	HOG000010898.
KO	K00995.
OMA	QERENTS.
ProtClustDB	CLSK885249.
Enzyme and pathway databases
BioCyc	SEPI176279:GJJB-876-MONOMER.
UniPathway	UPA00084; UER00503.
Family and domain databases
InterPro	IPR000462. CDP-OH_P_trans. IPR004570. Phosphatidylglycerol_P_synth. [Graphical view]
Pfam	PF01066. CDP-OH_P_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000847. Phos_ph_gly_syn. 1 hit.
TIGRFAMs	TIGR00560. pgsA. 1 hit.
PROSITE	PS00379. CDP_ALCOHOL_P_TRANSF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGSA_STAEQ

Accession

Primary (citable) accession number: Q5HPQ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	February 15, 2005
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program