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Q5HPP5

- MUTS_STAEQ

UniProt

Q5HPP5 - MUTS_STAEQ

Protein

DNA mismatch repair protein MutS

Gene

mutS

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi601 – 6088ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. damaged DNA binding Source: UniProtKB-HAMAP
    3. mismatched DNA binding Source: InterPro

    GO - Biological processi

    1. mismatch repair Source: UniProtKB-HAMAP

    Keywords - Biological processi

    DNA damage, DNA repair

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSEPI176279:GJJB-889-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA mismatch repair protein MutSUniRule annotation
    Gene namesi
    Name:mutSUniRule annotation
    Ordered Locus Names:SERP0863
    OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
    Taxonomic identifieri176279 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000531: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 873873DNA mismatch repair protein MutSPRO_0000115143Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi176279.SERP0863.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5HPP5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DNA mismatch repair MutS family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0249.
    HOGENOMiHOG000221406.
    KOiK03555.
    OMAiSIAFMHA.
    OrthoDBiEOG6Q5NPV.

    Family and domain databases

    Gene3Di3.30.420.110. 1 hit.
    3.40.1170.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00096. MutS.
    InterProiIPR005748. DNA_mismatch_repair_MutS-1.
    IPR007695. DNA_mismatch_repair_MutS-lik_N.
    IPR000432. DNA_mismatch_repair_MutS_C.
    IPR007861. DNA_mismatch_repair_MutS_clamp.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR016151. DNA_mismatch_repair_MutS_N.
    IPR007860. DNA_mmatch_repair_MutS_con_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01624. MutS_I. 1 hit.
    PF05188. MutS_II. 1 hit.
    PF05192. MutS_III. 1 hit.
    PF05190. MutS_IV. 1 hit.
    PF00488. MutS_V. 1 hit.
    [Graphical view]
    SMARTiSM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    [Graphical view]
    SUPFAMiSSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF53150. SSF53150. 1 hit.
    SSF55271. SSF55271. 1 hit.
    TIGRFAMsiTIGR01070. mutS1. 1 hit.
    PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5HPP5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANITPMMQQ YLKIKSEYDD CLLFFRLGDF YEMFFDDAKE ASRVLEITLT    50
    KRDAKKENPI PMCGVPYHSA DNYIETLINK GYKVAICEQM EDPKQTKGMV 100
    RREVVRIITP GTVMDQNGMD EKKNNYILSF IENEEFGLCY CDVSTGELKV 150
    THFKDTATLL NEITTINPNE IVIKQALSEE LKRQINMITE TITVREDISD 200
    EDYDMNQLTH QLMHDTTQLL LDYIHHTQKR DLSHIEEVIE YAAVDYMKMD 250
    YYAKRNLELT ESIRLKSKKG TLLWLMDETK TPMGARRLKQ WIDRPLINKQ 300
    QINDRLNIVE EFMDRFIERD TLRNHLNQVY DIERLVGRVS YGNVNARDLI 350
    QLKHSISEIP HIKALLNELG AQTTTQFKEL EPLDDLLQIL EESLVEEPPI 400
    SIKDGGLFKN GFNAQLDEYL EASKNGKTWL AELQAKERER TGIKSLKISF 450
    NKVFGYFIEI TRANLNNFQP EAFGYNRKQT LSNAERFITD ELKEKEDIIL 500
    GAEDKAVELE YELFVKLREH IKTYTERLQK QAKIISELDC LQSFAEIAQK 550
    YNYVKPTFSD DKVLHLENSR HPVVERVMDY NDYVPNDCHL DDETFIYLIT 600
    GPNMSGKSTY MRQVAIISIM AQMGAYVPCD SATLPIFDQI FTRIGAADDL 650
    VSGKSTFMVE MLEAQKALTY ATENSLIIFD EIGRGTSTYD GLALAQAMIE 700
    YVAQTSHAKT LFSTHYHELT SLDQMLKCLK NVHVAANEYQ GELIFLHKVK 750
    DGAVDDSYGI QVAKLADLPN EVIDRAQVIL NAFEQKPSYQ LSHENTDNQQ 800
    TVPSYNDFGR TEEEQSVIET HTSNHNYEQA TFDLFDGYNQ QSEVECQIRE 850
    LNLSNMTPLE ALIKLNELQS QLK 873
    Length:873
    Mass (Da):100,777
    Last modified:February 15, 2005 - v1
    Checksum:i332AC9F98B46D3FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000029 Genomic DNA. Translation: AAW54254.1.
    RefSeqiYP_188445.1. NC_002976.3.

    Genome annotation databases

    EnsemblBacteriaiAAW54254; AAW54254; SERP0863.
    GeneIDi3240406.
    KEGGiser:SERP0863.
    PATRICi19612599. VBIStaEpi130894_0842.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000029 Genomic DNA. Translation: AAW54254.1 .
    RefSeqi YP_188445.1. NC_002976.3.

    3D structure databases

    ProteinModelPortali Q5HPP5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176279.SERP0863.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW54254 ; AAW54254 ; SERP0863 .
    GeneIDi 3240406.
    KEGGi ser:SERP0863.
    PATRICi 19612599. VBIStaEpi130894_0842.

    Phylogenomic databases

    eggNOGi COG0249.
    HOGENOMi HOG000221406.
    KOi K03555.
    OMAi SIAFMHA.
    OrthoDBi EOG6Q5NPV.

    Enzyme and pathway databases

    BioCyci SEPI176279:GJJB-889-MONOMER.

    Family and domain databases

    Gene3Di 3.30.420.110. 1 hit.
    3.40.1170.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00096. MutS.
    InterProi IPR005748. DNA_mismatch_repair_MutS-1.
    IPR007695. DNA_mismatch_repair_MutS-lik_N.
    IPR000432. DNA_mismatch_repair_MutS_C.
    IPR007861. DNA_mismatch_repair_MutS_clamp.
    IPR007696. DNA_mismatch_repair_MutS_core.
    IPR016151. DNA_mismatch_repair_MutS_N.
    IPR007860. DNA_mmatch_repair_MutS_con_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01624. MutS_I. 1 hit.
    PF05188. MutS_II. 1 hit.
    PF05192. MutS_III. 1 hit.
    PF05190. MutS_IV. 1 hit.
    PF00488. MutS_V. 1 hit.
    [Graphical view ]
    SMARTi SM00534. MUTSac. 1 hit.
    SM00533. MUTSd. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48334. SSF48334. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF53150. SSF53150. 1 hit.
    SSF55271. SSF55271. 1 hit.
    TIGRFAMsi TIGR01070. mutS1. 1 hit.
    PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
      Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
      , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
      J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35984 / RP62A.

    Entry informationi

    Entry nameiMUTS_STAEQ
    AccessioniPrimary (citable) accession number: Q5HPP5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3