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Q5HPP5

- MUTS_STAEQ

UniProt

Q5HPP5 - MUTS_STAEQ

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Protein

DNA mismatch repair protein MutS

Gene

mutS

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi601 – 6088ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. damaged DNA binding Source: UniProtKB-HAMAP
  3. mismatched DNA binding Source: InterPro

GO - Biological processi

  1. mismatch repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-889-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA mismatch repair protein MutSUniRule annotation
Gene namesi
Name:mutSUniRule annotation
Ordered Locus Names:SERP0863
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000531: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 873873DNA mismatch repair protein MutSPRO_0000115143Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP0863.

Structurei

3D structure databases

ProteinModelPortaliQ5HPP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DNA mismatch repair MutS family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0249.
HOGENOMiHOG000221406.
KOiK03555.
OMAiSIAFMHA.
OrthoDBiEOG6Q5NPV.

Family and domain databases

Gene3Di3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00096. MutS.
InterProiIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTiSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMiSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsiTIGR01070. mutS1. 1 hit.
PROSITEiPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HPP5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANITPMMQQ YLKIKSEYDD CLLFFRLGDF YEMFFDDAKE ASRVLEITLT
60 70 80 90 100
KRDAKKENPI PMCGVPYHSA DNYIETLINK GYKVAICEQM EDPKQTKGMV
110 120 130 140 150
RREVVRIITP GTVMDQNGMD EKKNNYILSF IENEEFGLCY CDVSTGELKV
160 170 180 190 200
THFKDTATLL NEITTINPNE IVIKQALSEE LKRQINMITE TITVREDISD
210 220 230 240 250
EDYDMNQLTH QLMHDTTQLL LDYIHHTQKR DLSHIEEVIE YAAVDYMKMD
260 270 280 290 300
YYAKRNLELT ESIRLKSKKG TLLWLMDETK TPMGARRLKQ WIDRPLINKQ
310 320 330 340 350
QINDRLNIVE EFMDRFIERD TLRNHLNQVY DIERLVGRVS YGNVNARDLI
360 370 380 390 400
QLKHSISEIP HIKALLNELG AQTTTQFKEL EPLDDLLQIL EESLVEEPPI
410 420 430 440 450
SIKDGGLFKN GFNAQLDEYL EASKNGKTWL AELQAKERER TGIKSLKISF
460 470 480 490 500
NKVFGYFIEI TRANLNNFQP EAFGYNRKQT LSNAERFITD ELKEKEDIIL
510 520 530 540 550
GAEDKAVELE YELFVKLREH IKTYTERLQK QAKIISELDC LQSFAEIAQK
560 570 580 590 600
YNYVKPTFSD DKVLHLENSR HPVVERVMDY NDYVPNDCHL DDETFIYLIT
610 620 630 640 650
GPNMSGKSTY MRQVAIISIM AQMGAYVPCD SATLPIFDQI FTRIGAADDL
660 670 680 690 700
VSGKSTFMVE MLEAQKALTY ATENSLIIFD EIGRGTSTYD GLALAQAMIE
710 720 730 740 750
YVAQTSHAKT LFSTHYHELT SLDQMLKCLK NVHVAANEYQ GELIFLHKVK
760 770 780 790 800
DGAVDDSYGI QVAKLADLPN EVIDRAQVIL NAFEQKPSYQ LSHENTDNQQ
810 820 830 840 850
TVPSYNDFGR TEEEQSVIET HTSNHNYEQA TFDLFDGYNQ QSEVECQIRE
860 870
LNLSNMTPLE ALIKLNELQS QLK
Length:873
Mass (Da):100,777
Last modified:February 15, 2005 - v1
Checksum:i332AC9F98B46D3FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW54254.1.
RefSeqiYP_188445.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW54254; AAW54254; SERP0863.
GeneIDi3240406.
KEGGiser:SERP0863.
PATRICi19612599. VBIStaEpi130894_0842.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW54254.1 .
RefSeqi YP_188445.1. NC_002976.3.

3D structure databases

ProteinModelPortali Q5HPP5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176279.SERP0863.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW54254 ; AAW54254 ; SERP0863 .
GeneIDi 3240406.
KEGGi ser:SERP0863.
PATRICi 19612599. VBIStaEpi130894_0842.

Phylogenomic databases

eggNOGi COG0249.
HOGENOMi HOG000221406.
KOi K03555.
OMAi SIAFMHA.
OrthoDBi EOG6Q5NPV.

Enzyme and pathway databases

BioCyci SEPI176279:GJJB-889-MONOMER.

Family and domain databases

Gene3Di 3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00096. MutS.
InterProi IPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view ]
SMARTi SM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view ]
SUPFAMi SSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsi TIGR01070. mutS1. 1 hit.
PROSITEi PS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62A.

Entry informationi

Entry nameiMUTS_STAEQ
AccessioniPrimary (citable) accession number: Q5HPP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: February 15, 2005
Last modified: October 1, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3