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Q5HPP5 (MUTS_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA mismatch repair protein MutS
Gene names
Name:mutS
Ordered Locus Names:SERP0863
OrganismStaphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]
Taxonomic identifier176279 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length873 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity By similarity. HAMAP-Rule MF_00096

Sequence similarities

Belongs to the DNA mismatch repair MutS family.

Ontologies

Keywords
   Biological processDNA damage
DNA repair
   LigandATP-binding
DNA-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmismatch repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

damaged DNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

mismatched DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 873873DNA mismatch repair protein MutS HAMAP-Rule MF_00096
PRO_0000115143

Regions

Nucleotide binding601 – 6088ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q5HPP5 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 332AC9F98B46D3FB

FASTA873100,777
        10         20         30         40         50         60 
MANITPMMQQ YLKIKSEYDD CLLFFRLGDF YEMFFDDAKE ASRVLEITLT KRDAKKENPI 

        70         80         90        100        110        120 
PMCGVPYHSA DNYIETLINK GYKVAICEQM EDPKQTKGMV RREVVRIITP GTVMDQNGMD 

       130        140        150        160        170        180 
EKKNNYILSF IENEEFGLCY CDVSTGELKV THFKDTATLL NEITTINPNE IVIKQALSEE 

       190        200        210        220        230        240 
LKRQINMITE TITVREDISD EDYDMNQLTH QLMHDTTQLL LDYIHHTQKR DLSHIEEVIE 

       250        260        270        280        290        300 
YAAVDYMKMD YYAKRNLELT ESIRLKSKKG TLLWLMDETK TPMGARRLKQ WIDRPLINKQ 

       310        320        330        340        350        360 
QINDRLNIVE EFMDRFIERD TLRNHLNQVY DIERLVGRVS YGNVNARDLI QLKHSISEIP 

       370        380        390        400        410        420 
HIKALLNELG AQTTTQFKEL EPLDDLLQIL EESLVEEPPI SIKDGGLFKN GFNAQLDEYL 

       430        440        450        460        470        480 
EASKNGKTWL AELQAKERER TGIKSLKISF NKVFGYFIEI TRANLNNFQP EAFGYNRKQT 

       490        500        510        520        530        540 
LSNAERFITD ELKEKEDIIL GAEDKAVELE YELFVKLREH IKTYTERLQK QAKIISELDC 

       550        560        570        580        590        600 
LQSFAEIAQK YNYVKPTFSD DKVLHLENSR HPVVERVMDY NDYVPNDCHL DDETFIYLIT 

       610        620        630        640        650        660 
GPNMSGKSTY MRQVAIISIM AQMGAYVPCD SATLPIFDQI FTRIGAADDL VSGKSTFMVE 

       670        680        690        700        710        720 
MLEAQKALTY ATENSLIIFD EIGRGTSTYD GLALAQAMIE YVAQTSHAKT LFSTHYHELT 

       730        740        750        760        770        780 
SLDQMLKCLK NVHVAANEYQ GELIFLHKVK DGAVDDSYGI QVAKLADLPN EVIDRAQVIL 

       790        800        810        820        830        840 
NAFEQKPSYQ LSHENTDNQQ TVPSYNDFGR TEEEQSVIET HTSNHNYEQA TFDLFDGYNQ 

       850        860        870 
QSEVECQIRE LNLSNMTPLE ALIKLNELQS QLK 

« Hide

References

[1]"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. expand/collapse author list , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000029 Genomic DNA. Translation: AAW54254.1.
RefSeqYP_188445.1. NC_002976.3.

3D structure databases

ProteinModelPortalQ5HPP5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176279.SERP0863.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW54254; AAW54254; SERP0863.
GeneID3240406.
KEGGser:SERP0863.
PATRIC19612599. VBIStaEpi130894_0842.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0249.
HOGENOMHOG000221406.
KOK03555.
OMAGFGAHSL.
OrthoDBEOG6Q5NPV.
ProtClustDBPRK05399.

Enzyme and pathway databases

BioCycSEPI176279:GJJB-889-MONOMER.

Family and domain databases

Gene3D3.30.420.110. 1 hit.
3.40.1170.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_00096. MutS.
InterProIPR005748. DNA_mismatch_repair_MutS-1.
IPR007695. DNA_mismatch_repair_MutS-lik_N.
IPR000432. DNA_mismatch_repair_MutS_C.
IPR007861. DNA_mismatch_repair_MutS_clamp.
IPR007696. DNA_mismatch_repair_MutS_core.
IPR016151. DNA_mismatch_repair_MutS_N.
IPR007860. DNA_mmatch_repair_MutS_con_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR11361:SF34. PTHR11361:SF34. 1 hit.
PfamPF01624. MutS_I. 1 hit.
PF05188. MutS_II. 1 hit.
PF05192. MutS_III. 1 hit.
PF05190. MutS_IV. 1 hit.
PF00488. MutS_V. 1 hit.
[Graphical view]
SMARTSM00534. MUTSac. 1 hit.
SM00533. MUTSd. 1 hit.
[Graphical view]
SUPFAMSSF48334. SSF48334. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF53150. SSF53150. 1 hit.
SSF55271. SSF55271. 1 hit.
TIGRFAMsTIGR01070. mutS1. 1 hit.
PROSITEPS00486. DNA_MISMATCH_REPAIR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMUTS_STAEQ
AccessionPrimary (citable) accession number: Q5HPP5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: February 15, 2005
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families