Q5HPJ2 (MSCL_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Large-conductance mechanosensitive channel

Gene names

Name:	mscL
Ordered Locus Names:	SERP0919

Organism

Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]

Taxonomic identifier

176279 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	116 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity. HAMAP MF_00115
Subunit structure	Homopentamer By similarity. HAMAP MF_00115
Subcellular location	Cell membrane; Multi-pass membrane protein HAMAP MF_00115.
Sequence similarities	Belongs to the MscL family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Ionic channel
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 116	116	Large-conductance mechanosensitive channel HAMAP MF_00115		PRO_0000192468
Regions
	Topological domain	1 – 16	16	Cytoplasmic Potential
	Transmembrane	17 – 39	23	Helical; Potential
	Topological domain	40 – 64	25	Extracellular Potential
	Transmembrane	65 – 84	20	Helical; Potential
	Topological domain	85 – 116	32	Cytoplasmic Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5HPJ2 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 1C3DA2304B9D5993	FASTA	116	13,254
	10 20 30 40 50 60 MLKEFKEFAL KGNVLDLAIA VVMGAAFNKI VTSLVQYIIM PLIGKLFGSV NFAEDWSFWG 70 80 90 100 110 IKYGLFIQSI IDFIIIAFAL FIFVKIANTV MKKEEKEEEV EENTVLLTEI RDLLKK

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000029 Genomic DNA. Translation: AAW54294.1.
RefSeq	YP_188498.1. NC_002976.3.
3D structure databases
ProteinModelPortal	Q5HPJ2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HPJ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000043741; EBSTAP00000042284; EBSTAG00000043739.
GeneID	3241521.
GenomeReviews	Gene locus SERP0919 in contig CP000029_GR.
KEGG	ser:SERP0919.
PATRIC	19612707. VBIStaEpi130894_0896.
TIGR	SERP0919.
Phylogenomic databases
eggNOG	COG1970.
GeneTree	EBGT00050000025511.
HOGENOM	HBG727604.
OMA	LMVRAIT.
ProtClustDB	PRK13954.
Enzyme and pathway databases
BioCyc	SEPI176279:SERP0919-MONOMER.
Family and domain databases
HAMAP	MF_00115. MscL. [Tree]
InterPro	IPR019823. Mechanosensitive_channel_CS. IPR001185. MS_channel. [Graphical view]
KO	K03282.
Pfam	PF01741. MscL. 1 hit. [Graphical view]
PRINTS	PR01264. MECHCHANNEL.
SUPFAM	SSF81330. MS_channel. 1 hit.
TIGRFAMs	TIGR00220. MscL. 1 hit.
PROSITE	PS01327. MSCL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MSCL_STAEQ

Accession

Primary (citable) accession number: Q5HPJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	February 15, 2005
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program