Q5HPI0 (Q5HPI0_STAEQ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrA 1 HAMAP MF_01401
Short name=Protein-methionine-S-oxide reductase 1 HAMAP MF_01401
EC=1.8.4.11 HAMAP MF_01401

Alternative name(s):
Peptide-methionine (S)-S-oxide reductase 1 HAMAP MF_01401

Gene names

Name:	msrA-1 EMBL AAW54321.1
Synonyms:	msrA1 HAMAP MF_01401
Ordered Locus Names:	SERP0931

Organism

Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP] EMBL AAW54321.1

Taxonomic identifier

176279 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	171 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine By similarity. HAMAP MF_01401
Catalytic activity	L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401 Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin. HAMAP MF_01401
Sequence similarities	Belongs to the MsrA Met sulfoxide reductase family. HAMAP MF_01401

Ontologies

Keywords
Molecular function	Oxidoreductase HAMAP MF_01401 EMBL AAW54321.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein modification process Inferred from electronic annotation. Source: HAMAP
Molecular function	peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	12	1	By similarity HAMAP MF_01401

Sequences

	Sequence		Length	Mass (Da)
	Q5HPI0 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: BACEA45AE36CD83F	FASTA	171	19,862
	10 20 30 40 50 60 MNINTAYFAG GCFWCMTKPF DTFDGIEKVT SGYMGGHLVN PSYEEVKTGS TGHYEVVKIE 70 80 90 100 110 120 YDVALFSYHK LLEIFFSVID PLDDGGQFQD RGSQYKTAIF YSNEHQRQLA EQYICELQDS 130 140 150 160 170 FNADKAIATK ILPASTFYEA EVYHQDFYKK NPERYEQEQQ DRANYVKDNH M

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000029 Genomic DNA. Translation: AAW54321.1.
RefSeq	YP_188510.1. NC_002976.3.
3D structure databases
ProteinModelPortal	Q5HPI0.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HPI0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000043257; EBSTAP00000041800; EBSTAG00000043255.
GeneID	3242066.
GenomeReviews	Gene locus SERP0931 in contig CP000029_GR.
KEGG	ser:SERP0931.
NMPDR	fig|176279.3.peg.1011.
PATRIC	19612731. VBIStaEpi130894_0908.
TIGR	SERP0931.
Phylogenomic databases
eggNOG	COG0225.
GeneTree	EBGT00050000024265.
HOGENOM	HBG748152.
OMA	KIEYDVA.
PhylomeDB	Q5HPI0.
ProtClustDB	PRK14054.
Enzyme and pathway databases
BioCyc	SEPI176279:SERP0931-MONOMER.
Family and domain databases
HAMAP	MF_01401. MsrA. [Tree]
InterPro	IPR002569. Peptide_Met_Sox_Rdtase_MsrA. [Graphical view]
Gene3D	G3DSA:3.30.1060.10. MsrA. 1 hit.
KO	K07304.
Pfam	PF01625. PMSR. 1 hit. [Graphical view]
SUPFAM	SSF55068. MsrA. 1 hit.
TIGRFAMs	TIGR00401. MsrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q5HPI0_STAEQ

Accession

Primary (citable) accession number: Q5HPI0

Entry history

Integrated into UniProtKB/TrEMBL:	February 15, 2005
Last sequence update:	February 15, 2005
Last modified:	December 14, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)