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Q5HPH6 (TYRA_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prephenate dehydrogenase

Short name=PDH
EC=1.3.1.12
Gene names
Name:tyrA
Ordered Locus Names:SERP0936
OrganismStaphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]
Taxonomic identifier176279 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length362 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Catalytic activity

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathway

Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.

Sequence similarities

Contains 1 ACT domain.

Contains 1 prephenate/arogenate dehydrogenase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 362362Prephenate dehydrogenase
PRO_0000282664

Regions

Domain2 – 291290Prephenate/arogenate dehydrogenase
Domain296 – 36267ACT
Nucleotide binding3 – 3331NAD Potential

Sequences

Sequence LengthMass (Da)Tools
Q5HPH6 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: BB0D1A12046E0A3B

FASTA36240,710
        10         20         30         40         50         60 
MRNILFVGLG LIGGSLASNL KYHYSNFNIL AYDSDYTQLD EALSIGIIDQ KVNDYATAVE 

        70         80         90        100        110        120 
IADIIIFATP VEQTIKYLSE LTNYNTKTHL IVTDTGSTKL TIQSFEKELL KHDIHLISGH 

       130        140        150        160        170        180 
PMAGSHKSGV LNAKKHLFEN AYYILVFNEI ENNEAATYLK KLLKPTLAKF IVTHANEHDF 

       190        200        210        220        230        240 
VTGIVSHVPH IIASILVHLS ANHVKDHSLI EKLAAGGFRD ITRIASSNAQ MWKDITLNNQ 

       250        260        270        280        290        300 
NHILSLLNEI KEQITGIENL IREQNSNSIY DFFVKAKDYR DQLPVKQHGA ISTAYDLYVD 

       310        320        330        340        350        360 
IPDKPGMISQ ITNIISSHNI SIINLKILEV REDIYGALQI SFKSPEDREN AIKALANFDT 


YY 

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References

[1]"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. expand/collapse author list , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000029 Genomic DNA. Translation: AAW54325.1.
RefSeqYP_188514.1. NC_002976.3.

3D structure databases

ProteinModelPortalQ5HPH6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176279.SERP0936.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW54325; AAW54325; SERP0936.
GeneID3242071.
KEGGser:SERP0936.
PATRIC19612743. VBIStaEpi130894_0914.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0287.
HOGENOMHOG000043494.
KOK04517.
OMALQITFKN.
OrthoDBEOG6B8XMB.

Enzyme and pathway databases

BioCycSEPI176279:GJJB-962-MONOMER.
UniPathwayUPA00122; UER00961.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamPF01842. ACT. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
PROSITEPS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYRA_STAEQ
AccessionPrimary (citable) accession number: Q5HPH6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways