Reviewed, UniProtKB/Swiss-Prot Q5HPH6 (TYRA_STAEQ)

Names and origin

Protein names

Recommended name:
    Prephenate dehydrogenase
      Short name=PDH
    EC=1.3.1.12

Gene names

Name:	tyrA
Ordered Locus Names:	SERP0936

Organism

Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]

Taxonomic identifier

176279 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	362 AA.
Sequence status	Complete.
Protein existence	Predicted.

General annotation (Comments)

Catalytic activity	Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.
Pathway	Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NAD(+) route): step 1/1.
Sequence similarities	Contains 1 ACT domain. Contains 1 prephenate/arogenate dehydrogenase domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tyrosine biosynthesis
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro prephenate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: InterPro prephenate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 362	362	Prephenate dehydrogenase		PRO_0000282664
Regions
	Domain	2 – 291	290	Prephenate/arogenate dehydrogenase
	Domain	295 – 355	61	ACT
	Nucleotide binding	3 – 33	31	NAD Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5HPH6-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: BB0D1A12046E0A3B	FASTA	362	40,710
	10 20 30 40 50 60 MRNILFVGLG LIGGSLASNL KYHYSNFNIL AYDSDYTQLD EALSIGIIDQ KVNDYATAVE 70 80 90 100 110 120 IADIIIFATP VEQTIKYLSE LTNYNTKTHL IVTDTGSTKL TIQSFEKELL KHDIHLISGH 130 140 150 160 170 180 PMAGSHKSGV LNAKKHLFEN AYYILVFNEI ENNEAATYLK KLLKPTLAKF IVTHANEHDF 190 200 210 220 230 240 VTGIVSHVPH IIASILVHLS ANHVKDHSLI EKLAAGGFRD ITRIASSNAQ MWKDITLNNQ 250 260 270 280 290 300 NHILSLLNEI KEQITGIENL IREQNSNSIY DFFVKAKDYR DQLPVKQHGA ISTAYDLYVD 310 320 330 340 350 360 IPDKPGMISQ ITNIISSHNI SIINLKILEV REDIYGALQI SFKSPEDREN AIKALANFDT YY

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000029 Genomic DNA. Translation: AAW54325.1.
RefSeq	YP_188514.1.
3D structure databases
SMR	Q5HPH6. Positions 1-284.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HPH6.
Genome annotation databases
GeneID	3242071.
GenomeReviews	Gene locus SERP0936 in contig CP000029_GR.
KEGG	ser:SERP0936.
TIGR	SERP0936.
Phylogenomic databases
eggNOG	COG0287.
HOGENOM	HBG544990.
OMA	QRAIRWG.
Enzyme and pathway databases
BioCyc	SEPI176279:SERP0936-MONOMER.
Family and domain databases
InterPro	IPR002912. ACT_bd. IPR016040. NAD(P)-bd_dom. IPR003099. Prephen_DH. [Graphical view]
PANTHER	PTHR21363. Prephen_DH. 1 hit.
Pfam	PF01842. ACT. 1 hit. PF02153. PDH. 1 hit. [Graphical view]
PROSITE	PS51176. PDH_ADH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYRA_STAEQ

Accession

Primary (citable) accession number: Q5HPH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	February 15, 2005
Last modified:	January 19, 2010
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)