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Q5HPH6

- TYRA_STAEQ

UniProt

Q5HPH6 - TYRA_STAEQ

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Protein

Prephenate dehydrogenase

Gene

tyrA

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi3 – 3331NADSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. amino acid binding Source: InterPro
  2. prephenate dehydrogenase (NADP+) activity Source: InterPro
  3. prephenate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. tyrosine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-962-MONOMER.
UniPathwayiUPA00122; UER00961.

Names & Taxonomyi

Protein namesi
Recommended name:
Prephenate dehydrogenase (EC:1.3.1.12)
Short name:
PDH
Gene namesi
Name:tyrA
Ordered Locus Names:SERP0936
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000531: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 362362Prephenate dehydrogenasePRO_0000282664Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP0936.

Structurei

3D structure databases

ProteinModelPortaliQ5HPH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 291290Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd
BLAST
Domaini296 – 36267ACTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ACT domain.PROSITE-ProRule annotation
Contains 1 prephenate/arogenate dehydrogenase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0287.
HOGENOMiHOG000043494.
KOiK04517.
OMAiLQITFKN.
OrthoDBiEOG6B8XMB.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view]
PfamiPF01842. ACT. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
PROSITEiPS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HPH6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRNILFVGLG LIGGSLASNL KYHYSNFNIL AYDSDYTQLD EALSIGIIDQ
60 70 80 90 100
KVNDYATAVE IADIIIFATP VEQTIKYLSE LTNYNTKTHL IVTDTGSTKL
110 120 130 140 150
TIQSFEKELL KHDIHLISGH PMAGSHKSGV LNAKKHLFEN AYYILVFNEI
160 170 180 190 200
ENNEAATYLK KLLKPTLAKF IVTHANEHDF VTGIVSHVPH IIASILVHLS
210 220 230 240 250
ANHVKDHSLI EKLAAGGFRD ITRIASSNAQ MWKDITLNNQ NHILSLLNEI
260 270 280 290 300
KEQITGIENL IREQNSNSIY DFFVKAKDYR DQLPVKQHGA ISTAYDLYVD
310 320 330 340 350
IPDKPGMISQ ITNIISSHNI SIINLKILEV REDIYGALQI SFKSPEDREN
360
AIKALANFDT YY
Length:362
Mass (Da):40,710
Last modified:February 15, 2005 - v1
Checksum:iBB0D1A12046E0A3B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW54325.1.
RefSeqiYP_188514.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW54325; AAW54325; SERP0936.
GeneIDi3242071.
KEGGiser:SERP0936.
PATRICi19612743. VBIStaEpi130894_0914.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW54325.1 .
RefSeqi YP_188514.1. NC_002976.3.

3D structure databases

ProteinModelPortali Q5HPH6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176279.SERP0936.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW54325 ; AAW54325 ; SERP0936 .
GeneIDi 3242071.
KEGGi ser:SERP0936.
PATRICi 19612743. VBIStaEpi130894_0914.

Phylogenomic databases

eggNOGi COG0287.
HOGENOMi HOG000043494.
KOi K04517.
OMAi LQITFKN.
OrthoDBi EOG6B8XMB.

Enzyme and pathway databases

UniPathwayi UPA00122 ; UER00961 .
BioCyci SEPI176279:GJJB-962-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR002912. ACT_dom.
IPR016040. NAD(P)-bd_dom.
IPR003099. Prephen_DH.
[Graphical view ]
Pfami PF01842. ACT. 1 hit.
PF02153. PDH. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
PROSITEi PS51671. ACT. 1 hit.
PS51176. PDH_ADH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62A.

Entry informationi

Entry nameiTYRA_STAEQ
AccessioniPrimary (citable) accession number: Q5HPH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: February 15, 2005
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3