Q5HPH2 (TRPC_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	SERP0940

Organism

Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]

Taxonomic identifier

176279 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_0000154256

Sequences

	Sequence		Length	Mass (Da)
	Q5HPH2 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 06AB9C605A0A9EF3	FASTA	262	30,056
	10 20 30 40 50 60 MTILNEIIEY KKTLLERKYY DKKLEILQDN GNVKRRKLID SLNYDRTLSV IAEIKSKSPS 70 80 90 100 110 120 VPQLPQRDLV QQVKDYQKYG ANAISILTDE KYFGGSFERL NQLSKITSLP VLCKDFIIDK 130 140 150 160 170 180 IQIDVAKRAG ASIILLIVNI LSDDQLKELY SYATNHNLEA LVEVHTIREL ERAHQINPKI 190 200 210 220 230 240 IGVNNRDLKR FETDVLHTNK LLKFKKSNCC YISESGIHTK EDVEKIVDSS IDGLLVGEAL 250 260 MKTNDLSQFL PSLKLKKNLY DS

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000029 Genomic DNA. Translation: AAW54337.1.
RefSeq	YP_188518.1. NC_002976.3.
3D structure databases
ProteinModelPortal	Q5HPH2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HPH2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000043663; EBSTAP00000042206; EBSTAG00000043661.
GeneID	3242083.
GenomeReviews	Gene locus SERP0940 in contig CP000029_GR.
KEGG	ser:SERP0940.
NMPDR	fig|176279.3.peg.1019.
PATRIC	19612751. VBIStaEpi130894_0918.
TIGR	SERP0940.
Phylogenomic databases
eggNOG	COG0134.
GeneTree	EBGT00050000025434.
HOGENOM	HBG540956.
OMA	FETDINT.
PhylomeDB	Q5HPH2.
ProtClustDB	PRK00278.
Enzyme and pathway databases
BioCyc	SEPI176279:SERP0940-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_STAEQ

Accession

Primary (citable) accession number: Q5HPH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	February 15, 2005
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program