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Q5HPC6

- ODO1_STAEQ

UniProt

Q5HPC6 - ODO1_STAEQ

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Protein

2-oxoglutarate dehydrogenase E1 component

Gene
odhA, SERP0986
Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

Thiamine pyrophosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-1012-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:odhA
Ordered Locus Names:SERP0986
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000531: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9349342-oxoglutarate dehydrogenase E1 componentUniRule annotationPRO_0000162182Add
BLAST

Proteomic databases

PRIDEiQ5HPC6.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi176279.SERP0986.

Structurei

3D structure databases

ProteinModelPortaliQ5HPC6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259588.
KOiK00164.
OMAiGFTTAPH.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HPC6-1 [UniParc]FASTAAdd to Basket

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MTKNKKEFTE APVNFGANLG LMLDLYDDYL QDPSSVPEDL QVLFSTIKTG    50
EAHIEAKPTT DGGGSQAGDS TIKRVMRLID NIRQYGHLKA DIYPVNPPER 100
QNVPKLEIED FDLDKETLEK ISSGIVSEHF KDIYDNAYDA IVRMERRYKG 150
PIAFEYTHIN NNKERVWLKR RIETPYKASL NDNQKKELFK KLAHVEGFEK 200
YLHKNFVGAK RFSIEGVDTL VPMLQHTITL AGNEGIKNIQ IGMAHRGRLN 250
VLTHVLEKPY EMMISEFMHT DPMKFLPEDG SLELTSGWTS DVKYHLGGVK 300
TTNSYGIEQR ISLANNPSHL EIVAPVVAGK TRAAQDNTHQ VGGPSTDFHK 350
AMPIIIHGDA AYPGQGINFE TMNLGSLKGY STGGSLHIIT NNRIGFTTEP 400
FDGRSTTYSS DVAKGYDVPI LHVNADDVEA TIEAIEIAME FRKEFHKDVV 450
IDLVGYRRYG HNEMDEPSIT NPVPYQNIRK HDSVEILYGK KLVDEGIISE 500
DEMNEVIDSV QKEMRTAHDK IDKNDKMNNP DMEKPESLQL PLQSDTKDFS 550
FDHLKEINDA MLDYPKDFHV LKKLNKVLEK RREPFEKEGG LVDWAQAEQL 600
AFATILQDGT SIRLTGQDSE RGTFSHRHAV LHDEENGNTF TPLHHVPQQQ 650
ATFDIHNSPL SEAAVVGFEY GYNVENKGNF NIWEAQYGDF SNMSQMMFDN 700
FLSSSRAKWG ERSGLTLFLP HAFEGQGPEH SSARLERFLQ LAAENNSTVV 750
NLSSASNYFH LLRAQAASLD TLEMRPLIVM SPKSLLRNKT VAKPIDEFTS 800
GGFKPIITED IDEQKVKKVI LASGKMYIDL KEYLAKNPND SILLIAVERL 850
YPFPEEEIKE VLKSLPHLEN VSWVQEEPKN QGAWLFVYPY LKALVANKYD 900
LTYHGRIQRA APAEGDGEIH KLVQTKIIES SINN 934
Length:934
Mass (Da):105,671
Last modified:February 15, 2005 - v1
Checksum:i711FD468A5FB2EC5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW54333.1.
RefSeqiYP_188564.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW54333; AAW54333; SERP0986.
GeneIDi3242079.
KEGGiser:SERP0986.
PATRICi19612841. VBIStaEpi130894_0963.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW54333.1 .
RefSeqi YP_188564.1. NC_002976.3.

3D structure databases

ProteinModelPortali Q5HPC6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176279.SERP0986.

Proteomic databases

PRIDEi Q5HPC6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW54333 ; AAW54333 ; SERP0986 .
GeneIDi 3242079.
KEGGi ser:SERP0986.
PATRICi 19612841. VBIStaEpi130894_0963.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259588.
KOi K00164.
OMAi GFTTAPH.
OrthoDBi EOG6V1M1F.

Enzyme and pathway databases

BioCyci SEPI176279:GJJB-1012-MONOMER.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62A.

Entry informationi

Entry nameiODO1_STAEQ
AccessioniPrimary (citable) accession number: Q5HPC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: February 15, 2005
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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