Q5HPB5 (PTGA_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-specific phosphotransferase enzyme IIA component
EC=2.7.1.-

Alternative name(s):
EIIA-Glc
EIII-Glc
PTS system glucose-specific EIIA component

Gene names

Name:	crr
Ordered Locus Names:	SERP0998

Organism

Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]

Taxonomic identifier

176279 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	166 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in glucose transport By similarity.
Catalytic activity	Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.
Subcellular location	Cytoplasm By similarity.
Domain	The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.
Sequence similarities	Contains 1 PTS EIIA type-1 domain.

Ontologies

Keywords
Biological process	Phosphotransferase system Sugar transport Transport
Cellular component	Cytoplasm
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphoenolpyruvate-dependent sugar phosphotransferase system Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro
Molecular function	kinase activity Inferred from electronic annotation. Source: UniProtKB-KW sugar:hydrogen symporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 166	166	Glucose-specific phosphotransferase enzyme IIA component		PRO_0000186555
Regions
	Domain	34 – 138	105	PTS EIIA type-1
Sites
	Active site	86	1	Tele-phosphohistidine intermediate By similarity
	Site	71	1	Important for phospho-donor activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5HPB5 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 76C73246ABF87971	FASTA	166	18,136
	10 20 30 40 50 60 MFKKLFGKAK EVDKNIKIYA PLTGEYVKIE DIPDPVFAQK MMGEGFGINP TEGEVVSPIE 70 80 90 100 110 120 GKVDNVFPTK HAVGLKAENG LELLVHIGLD TVQLDGKGFE VLVESGDDIK IGDPLIRFDL 130 140 150 160 EYINNNAKSI ISPIIITNSD QTESIHIEDV QAVVKGETQV IDVTVS

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000029 Genomic DNA. Translation: AAW54360.1.
RefSeq	YP_188575.1. NC_002976.3.
3D structure databases
ProteinModelPortal	Q5HPB5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HPB5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000043762; EBSTAP00000042305; EBSTAG00000043760.
GeneID	3242023.
GenomeReviews	Gene locus SERP0998 in contig CP000029_GR.
KEGG	ser:SERP0998.
PATRIC	19612859. VBIStaEpi130894_0972.
TIGR	SERP0998.
Phylogenomic databases
eggNOG	COG2190.
GeneTree	EBGT00050000023800.
HOGENOM	HBG517865.
OMA	RRLISGQ.
ProtClustDB	CLSK885342.
Enzyme and pathway databases
BioCyc	SEPI176279:SERP0998-MONOMER.
Family and domain databases
InterPro	IPR011055. Dup_hybrid_motif. IPR001127. PTS_EIIA_1_perm. [Graphical view]
KO	K02777.
Pfam	PF00358. PTS_EIIA_1. 1 hit. [Graphical view]
SUPFAM	SSF51261. Dup_hybrid_motif. 1 hit.
TIGRFAMs	TIGR00830. PTBA. 1 hit.
PROSITE	PS51093. PTS_EIIA_TYPE_1. 1 hit. PS00371. PTS_EIIA_TYPE_1_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PTGA_STAEQ

Accession

Primary (citable) accession number: Q5HPB5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	February 15, 2005
Last modified:	January 25, 2012
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program