Q5HPB4 (MSRB_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrB
EC=1.8.4.12

Alternative name(s):
Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	SERP0999

Organism

Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]

Taxonomic identifier

176279 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Peptide methionine sulfoxide reductase MsrB HAMAP MF_01400		PRO_0000140302
Sites
	Active site	114	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5HPB4 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 1FA44CE8ABB4E505	FASTA	142	16,416
	10 20 30 40 50 60 MIKKNKEELN DMEYLVTQEN GTEPPFQNEY WNHFEKGIYV DKLSGKPLFT SEDKFESNCG 70 80 90 100 110 120 WPSFSKALND DEIVELVDKS FGMIRTEVRS EKANSHLGHV FNDGPKEKGG LRYCINSAAI 130 140 QFIPYDKLEE LGYGDLIKHF KK

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000029 Genomic DNA. Translation: AAW54361.1.
RefSeq	YP_188576.1. NC_002976.3.
3D structure databases
ProteinModelPortal	Q5HPB4.
SMR	Q5HPB4. Positions 5-142.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HPB4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000042741; EBSTAP00000041284; EBSTAG00000042739.
GeneID	3242024.
GenomeReviews	Gene locus SERP0999 in contig CP000029_GR.
KEGG	ser:SERP0999.
PATRIC	19612861. VBIStaEpi130894_0973.
TIGR	SERP0999.
Phylogenomic databases
eggNOG	COG0229.
GeneTree	EBGT00050000024012.
HOGENOM	HBG715255.
OMA	FTDGPVD.
PhylomeDB	Q5HPB4.
ProtClustDB	PRK00222.
Enzyme and pathway databases
BioCyc	SEPI176279:SERP0999-MONOMER.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
KO	K07305.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_STAEQ

Accession

Primary (citable) accession number: Q5HPB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	February 15, 2005
Last modified:	January 25, 2012
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program