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Protein

Glycerol-3-phosphate dehydrogenase [NAD(P)+]

Gene

gpsA

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H.UniRule annotation

Pathwayi: glycerophospholipid metabolism

This protein is involved in the pathway glycerophospholipid metabolism, which is part of Membrane lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway glycerophospholipid metabolism and in Membrane lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106NAD; via amide nitrogenUniRule annotation1
Binding sitei106SubstrateUniRule annotation1
Binding sitei141NAD; via amide nitrogenUniRule annotation1
Active sitei192Proton acceptorUniRule annotation1
Binding sitei256NADUniRule annotation1
Binding sitei282NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 13NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00940

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(P)+]UniRule annotation (EC:1.1.1.94UniRule annotation)
Alternative name(s):
NAD(P)H-dependent glycerol-3-phosphate dehydrogenaseUniRule annotation
Gene namesi
Name:gpsAUniRule annotation
Ordered Locus Names:SERP1042
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000531 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001380301 – 332Glycerol-3-phosphate dehydrogenase [NAD(P)+]Add BLAST332

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP1042

Structurei

3D structure databases

ProteinModelPortaliQ5HP71
SMRiQ5HP71
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni256 – 257Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CSF Bacteria
COG0240 LUCA
HOGENOMiHOG000246854
KOiK00057
OMAiWLCKGFE

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
HAMAPiMF_00394 NAD_Glyc3P_dehydrog, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006168 G3P_DH_NAD-dep
IPR006109 G3P_DH_NAD-dep_C
IPR011128 G3P_DH_NAD-dep_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF07479 NAD_Gly3P_dh_C, 1 hit
PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFiPIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSiPR00077 GPDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00957 NAD_G3PDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HP71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKITVFGMG SFGTALANVL AQNGHDVLMW GKNVENVDEL NTHHMNKNYL
60 70 80 90 100
KDAKLDSSIK ATVDLNKAVQ FSDIYLMALP TKAIREVSKD IDQLLTSKKT
110 120 130 140 150
FIHVAKGIEN DTFKRVSEMI EDSISSEHNG GIGVLSGPSH AEEVVIKQPT
160 170 180 190 200
TVAASSKDNN VSKLIQDLFM NDYLRVYTNN DLVGVELGGA LKNIIAIASG
210 220 230 240 250
IVAGMGYGDN AKAALMTRGL AEISRLGEKL GADPMTFLGL GGIGDLIVTC
260 270 280 290 300
TSTHSRNYTL GFKLGQGKTA EEALKEMKMV VEGIYTTKSV YHLAQQEGVE
310 320 330
MPITNALYEV LFEDVPVSKS VRTLMERDKK AE
Length:332
Mass (Da):36,119
Last modified:February 15, 2005 - v1
Checksum:i1D29F1380C9E0765
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA Translation: AAW54433.1
RefSeqiWP_001831154.1, NC_002976.3

Genome annotation databases

EnsemblBacteriaiAAW54433; AAW54433; SERP1042
KEGGiser:SERP1042

Similar proteinsi

Entry informationi

Entry nameiGPDA_STAEQ
AccessioniPrimary (citable) accession number: Q5HP71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 15, 2005
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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