Q5HP48 (P5CR_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrroline-5-carboxylate reductase
Short name=P5C reductase
Short name=P5CR
EC=1.5.1.2

Gene names

Name:	proC
Ordered Locus Names:	SERP1065

Organism

Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]

Taxonomic identifier

176279 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	271 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the pyrroline-5-carboxylate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 271	271	Pyrroline-5-carboxylate reductase		PRO_0000187305

Sequences

	Sequence		Length	Mass (Da)
	Q5HP48 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: DBFFEDA2289255D7	FASTA	271	30,111
	10 20 30 40 50 60 MKLVFYGAGN MAQAIFTGII NSNNLNANDI YLTNKSNEQA LKSFAEKLGV NYSYDDEALL 70 80 90 100 110 120 KDADYVFLGT KPHDFENLAN RIREHITNDN RFISIMAGLS IDYIRQQLNT NNPLARIMPN 130 140 150 160 170 180 TNAQVGHSVT GISFSNNFDP KSKNEVDELI NAFGSVIEVS EEHLHQVTAI TGSGPAFLYH 190 200 210 220 230 240 VFEQYVKAGT ELGLERNQVE ESIRNLIIGT SKMIERSDLS MSQLRKNITS KGGTTQAGLD 250 260 270 ALSQYDIVSM FEDCLGAAVN RSMELSHKED E

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000029 Genomic DNA. Translation: AAW54423.1.
RefSeq	YP_188642.1. NC_002976.3.
3D structure databases
ProteinModelPortal	Q5HP48.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HP48.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000042000; EBSTAP00000040543; EBSTAG00000041998.
GeneID	3240712.
GenomeReviews	Gene locus SERP1065 in contig CP000029_GR.
KEGG	ser:SERP1065.
PATRIC	19612991. VBIStaEpi130894_1038.
TIGR	SERP1065.
Phylogenomic databases
eggNOG	COG0345.
GeneTree	EBGT00050000024862.
HOGENOM	HBG726602.
OMA	HKKYGVK.
PhylomeDB	Q5HP48.
ProtClustDB	CLSK885395.
Enzyme and pathway databases
BioCyc	SEPI176279:SERP1065-MONOMER.
Family and domain databases
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. Pyrroline-COOH_reductase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00286.
PANTHER	PTHR11645. P5CR. 1 hit.
Pfam	PF03807. F420_oxidored. 1 hit. [Graphical view]
PIRSF	PIRSF000193. Pyrrol-5-carb_rd. 1 hit.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMs	TIGR00112. ProC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

P5CR_STAEQ

Accession

Primary (citable) accession number: Q5HP48

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	February 15, 2005
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program