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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 2UniRule annotation
Glycine decarboxylase subunit 2UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
Gene namesi
Name:gcvPBUniRule annotation
Ordered Locus Names:SERP1100
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001670181 – 502Probable glycine dehydrogenase (decarboxylating) subunit 2Add BLAST502

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei273N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi176279.SERP1100

Structurei

3D structure databases

ProteinModelPortaliQ5HP14
SMRiQ5HP14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RGW Bacteria
COG1003 LUCA
HOGENOMiHOG000239368
KOiK00283
OMAiMHINLHK

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
HAMAPiMF_00713 GcvPB, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR023012 GcvPB
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q5HP14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISKSSPLIF ERSKKDRYAY SLPQNDIENI SIASLLDDKY IRKHKAEFPE
60 70 80 90 100
VSELDLVRHY TELSNKNFGV DTGFYPLGSC TMKYNPKINE KVARISGFSE
110 120 130 140 150
SHPLQEEEHV QGSLEIIYSL QEELKEITGM DEVTLQPAAG AHGEWTALMI
160 170 180 190 200
FKAYHEKNGQ SHRDEVIVPD SAHGTNPASA SFAGFKSVTV KSNQRGEVDI
210 220 230 240 250
EDLKRVVNDN TAAIMLTNPN TLGIFEQDII EIGKIVHEAG GLLYYDGANL
260 270 280 290 300
NAILDKVRPG DMGFDAVHLN LHKTFTGPHG GGGPGSGPVG VVEKLASYLP
310 320 330 340 350
KPMVIKDNDR YKYDNDIPNS IGRVKPFYGN FGIYLRAYTY IRSMGANGLK
360 370 380 390 400
EVSEAAVLNA NYIKSRLKNH FEIPFNQYCK HEFVLSGTLQ KQYGVRTLDM
410 420 430 440 450
AKRLLDFGVH PPTIYFPLNV EEGMMIEPTE TESKETLDYF IDAMIQIADE
460 470 480 490 500
TKNDPDKVLE APHTTIIDRL DETTAARKPI LKFEELKDEK YKEHTNIDSE

DN
Length:502
Mass (Da):56,404
Last modified:February 15, 2005 - v1
Checksum:iF2862E1B1281806C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA Translation: AAW54491.1
RefSeqiWP_001831087.1, NC_002976.3

Genome annotation databases

EnsemblBacteriaiAAW54491; AAW54491; SERP1100
KEGGiser:SERP1100

Entry informationi

Entry nameiGCSPB_STAEQ
AccessioniPrimary (citable) accession number: Q5HP14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 15, 2005
Last modified: May 23, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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