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Q5HNL1

- IDH_STAEQ

UniProt

Q5HNL1 - IDH_STAEQ

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 Mg(2+) or Mn(2+) ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei94 – 941NADPBy similarity
Binding sitei103 – 1031SubstrateBy similarity
Binding sitei105 – 1051SubstrateBy similarity
Binding sitei109 – 1091SubstrateBy similarity
Binding sitei119 – 1191SubstrateBy similarity
Binding sitei143 – 1431SubstrateBy similarity
Sitei150 – 1501Critical for catalysisBy similarity
Sitei220 – 2201Critical for catalysisBy similarity
Metal bindingi310 – 3101Magnesium or manganeseBy similarity
Binding sitei357 – 3571NADP; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei396 – 3961NADPBy similarity
Binding sitei400 – 4001NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi344 – 3507NADPBy similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NADP

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-1284-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP] (EC:1.1.1.42)
Short name:
IDH
Alternative name(s):
IDP
NADP(+)-specific ICDH
Oxalosuccinate decarboxylase
Gene namesi
Name:icd
Synonyms:citC
Ordered Locus Names:SERP1257
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000531: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Isocitrate dehydrogenase [NADP]PRO_0000083566Add
BLAST

Proteomic databases

PRIDEiQ5HNL1.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi176279.SERP1257.

Structurei

3D structure databases

ProteinModelPortaliQ5HNL1.
SMRiQ5HNL1. Positions 3-421.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000021113.
KOiK00031.
OMAiCLRPIRY.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HNL1-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSAEKITQSK DGLNVPNEPI IPFIIGDGIG PDIWKAASRV IDAAVEKAYN
60 70 80 90 100
GEKRIEWKEV LAGQKAYDET GEWLPQETLE TIKEYLIAVK GPLTTPIGGG
110 120 130 140 150
IRSLNVALRQ ELDLFTCLRP VRWFKGVPSP VKRPEDVDMV IFRENTEDIY
160 170 180 190 200
AGIEFKQGTS EVKKVIDFLQ NEMGATNIRF PETSGIGIKP VSKEGTERLV
210 220 230 240 250
RAAIQYALDN NRKSVTLVHK GNIMKFTEGS FKQWGYDLAH NEFGDKVFTW
260 270 280 290 300
QQYDEIVEQK GKDAANEAQS KAEQEGKIII KDSIADIFLQ QILTRPAEHD
310 320 330 340 350
VVATMNLNGD YISDALAAQV GGIGIAPGAN INYETGHAIF EATHGTAPKY
360 370 380 390 400
AGLNKVNPSS EILSSVLMLE HLGWQEAADK ITDSIEATIA SKIVTYDFAR
410 420
LMDGAKEVST SDFADELIKN IR
Length:422
Mass (Da):46,619
Last modified:February 15, 2005 - v1
Checksum:i31EA599CF275A83C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW54629.1.
RefSeqiYP_188830.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW54629; AAW54629; SERP1257.
GeneIDi3240849.
KEGGiser:SERP1257.
PATRICi19613365. VBIStaEpi130894_1225.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW54629.1 .
RefSeqi YP_188830.1. NC_002976.3.

3D structure databases

ProteinModelPortali Q5HNL1.
SMRi Q5HNL1. Positions 3-421.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176279.SERP1257.

Proteomic databases

PRIDEi Q5HNL1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW54629 ; AAW54629 ; SERP1257 .
GeneIDi 3240849.
KEGGi ser:SERP1257.
PATRICi 19613365. VBIStaEpi130894_1225.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000021113.
KOi K00031.
OMAi CLRPIRY.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci SEPI176279:GJJB-1284-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62A.

Entry informationi

Entry nameiIDH_STAEQ
AccessioniPrimary (citable) accession number: Q5HNL1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: February 15, 2005
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3