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Q5HNH4

- FTHS_STAEQ

UniProt

Q5HNH4 - FTHS_STAEQ

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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-1322-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:SERP1295
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000531: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligasePRO_0000199382Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP1295.

Structurei

3D structure databases

ProteinModelPortaliQ5HNH4.
SMRiQ5HNH4. Positions 6-553.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HNH4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQLSDLEIA NLSKLKPISE IARKVGITED ALEPYGHYKA KIDINQIQEQ
60 70 80 90 100
EKKGKVVLVT AMSPTPAGEG KSTVTVGLAD AFNKLNHNVT VALREPALGP
110 120 130 140 150
TFGIKGGATG GGYAQVLPME DINLHFNGDF HAITTANNAL SAFIDNHLHQ
160 170 180 190 200
GNELGIDQRR IEWKRVLDMN DRALRHVNVG LGGTTHGVPR EDGFNITVAS
210 220 230 240 250
EIMAILCLSR NIKDLKEKIS RITIGYTRHH KPITVSDLKV EGALTLILKD
260 270 280 290 300
AIKPNLVQTI EGTPALVHGG PFANIAHGCN SILATETARN LSDIVVTEAG
310 320 330 340 350
FGSDLGAEKF MNIKAREAGF DPSAVVVVAT IRALKMHGGV AKDQLQHENI
360 370 380 390 400
EAVEAGLVNL ERHVNNIKKY GVEPIVALNA FIHDTPSETA CVKQWAKDNQ
410 420 430 440 450
VRIALTEVWE KGGEGGIELA NQVFDVMQEP QNFKHLYELK QPLEAKIETI
460 470 480 490 500
VKEIYGGSKV NFSSKAQKQL KQFKENGWDE YPICMAKTQY SFSDDQTLLG
510 520 530 540 550
APNDFEITIR ELEAKTGAGF IVALTGAIMT MPGLPKKPAA LNMDVTDDGK

AIGLF
Length:555
Mass (Da):60,340
Last modified:February 15, 2005 - v1
Checksum:i9269FFF398EB5A0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW54703.1.
RefSeqiYP_188867.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW54703; AAW54703; SERP1295.
GeneIDi3241438.
KEGGiser:SERP1295.
PATRICi19613441. VBIStaEpi130894_1263.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW54703.1 .
RefSeqi YP_188867.1. NC_002976.3.

3D structure databases

ProteinModelPortali Q5HNH4.
SMRi Q5HNH4. Positions 6-553.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176279.SERP1295.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW54703 ; AAW54703 ; SERP1295 .
GeneIDi 3241438.
KEGGi ser:SERP1295.
PATRICi 19613441. VBIStaEpi130894_1263.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci SEPI176279:GJJB-1322-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62A.

Entry informationi

Entry nameiFTHS_STAEQ
AccessioniPrimary (citable) accession number: Q5HNH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: February 15, 2005
Last modified: October 1, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3