Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5HNH4 (FTHS_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:SERP1295
OrganismStaphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]
Taxonomic identifier176279 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199382

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5HNH4 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 9269FFF398EB5A0D

FASTA55560,340
        10         20         30         40         50         60 
MAQLSDLEIA NLSKLKPISE IARKVGITED ALEPYGHYKA KIDINQIQEQ EKKGKVVLVT 

        70         80         90        100        110        120 
AMSPTPAGEG KSTVTVGLAD AFNKLNHNVT VALREPALGP TFGIKGGATG GGYAQVLPME 

       130        140        150        160        170        180 
DINLHFNGDF HAITTANNAL SAFIDNHLHQ GNELGIDQRR IEWKRVLDMN DRALRHVNVG 

       190        200        210        220        230        240 
LGGTTHGVPR EDGFNITVAS EIMAILCLSR NIKDLKEKIS RITIGYTRHH KPITVSDLKV 

       250        260        270        280        290        300 
EGALTLILKD AIKPNLVQTI EGTPALVHGG PFANIAHGCN SILATETARN LSDIVVTEAG 

       310        320        330        340        350        360 
FGSDLGAEKF MNIKAREAGF DPSAVVVVAT IRALKMHGGV AKDQLQHENI EAVEAGLVNL 

       370        380        390        400        410        420 
ERHVNNIKKY GVEPIVALNA FIHDTPSETA CVKQWAKDNQ VRIALTEVWE KGGEGGIELA 

       430        440        450        460        470        480 
NQVFDVMQEP QNFKHLYELK QPLEAKIETI VKEIYGGSKV NFSSKAQKQL KQFKENGWDE 

       490        500        510        520        530        540 
YPICMAKTQY SFSDDQTLLG APNDFEITIR ELEAKTGAGF IVALTGAIMT MPGLPKKPAA 

       550 
LNMDVTDDGK AIGLF 

« Hide

References

[1]"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. expand/collapse author list , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000029 Genomic DNA. Translation: AAW54703.1.
RefSeqYP_188867.1. NC_002976.3.

3D structure databases

ProteinModelPortalQ5HNH4.
SMRQ5HNH4. Positions 6-553.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176279.SERP1295.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW54703; AAW54703; SERP1295.
GeneID3241438.
KEGGser:SERP1295.
PATRIC19613441. VBIStaEpi130894_1263.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.
ProtClustDBPRK13505.

Enzyme and pathway databases

BioCycSEPI176279:GJJB-1322-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_STAEQ
AccessionPrimary (citable) accession number: Q5HNH4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: February 15, 2005
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways