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Q5HNF1

- SYL_STAEQ

UniProt

Q5HNF1 - SYL_STAEQ

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Protein

Leucine--tRNA ligase

Gene
leuS, SERP1318
Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-1345-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:SERP1318
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000531: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 804804Leucine--tRNA ligaseUniRule annotationPRO_0000152089Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP1318.

Structurei

3D structure databases

ProteinModelPortaliQ5HNF1.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotationAdd
BLAST
Motifi576 – 5805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HNF1-1 [UniParc]FASTAAdd to Basket

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MNYNHKEIEK KWQNYWEENK TFKTNDNLGQ KKFYALDMFP YPSGAGLHVG    50
HPEGYTATDI ISRYKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPREFT 100
QKNIQTFKRQ IQELGFSYDW DREVNTTDPE YYKWTQWIFI QLYNKGLAYV 150
DEVAVNWCPA LGTVLSNEEV VDGVSERGGH PVYRKPMKQW VLKITEYADR 200
LLEDLDELDW PESIKDMQRN WIGRSEGAKV TFKIEQSDQN IEVFTTRPDT 250
IYGTSFLVLS PEHPLVNEIT TSDKEQEVKL YQNEASKKSD LERTDLAKEK 300
TGVFTGTFAI NPLSGDKLPI WIADYVLSTY GTGAVMAVPG HDERDHEFAT 350
KFNLPIIEVI EGGEVQKYAY TGEGKHINSG ELDGLENEAA ISKAIELLES 400
KGAGEKKVNY KLRDWLFSRQ RYWGEPIPII HWEDGSMTTV PEDELPLLLP 450
ETDEIKPSGT GESPLANIDA FVNVIDEKTG MKGRRETNTM PQWAGSCWYY 500
LRYIDPHNEK MIADPEKLKH WLPVDLYIGG VEHAVLHLLY ARFWHKVLYD 550
LGVVPTKEPF QKLYNQGMIL GEGNEKMSKS KGNVINPDDI VASHGADTLR 600
LYEMFMGPLD AAIAWSEKGL DGSRRFLDRV WRLIITDENS INKKIVDSNN 650
HSLDKVYNQT VKKVTEDFDT LSFNTAISQL MVFINECYKT NEVYKPYIEG 700
FVKMLSPIAP HIGEELWDRL GHENTITYQP WPTFDESLLV DDEVEIVVQV 750
NGKVRAKINI PKDLSKEEMQ DLALSNDNVK MSIEGKEVKK VIAVPQKLVN 800
IVAK 804
Length:804
Mass (Da):92,164
Last modified:February 15, 2005 - v1
Checksum:i173B55466D9C0725
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW54646.1.
RefSeqiYP_188890.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW54646; AAW54646; SERP1318.
GeneIDi3241697.
KEGGiser:SERP1318.
PATRICi19613485. VBIStaEpi130894_1285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW54646.1 .
RefSeqi YP_188890.1. NC_002976.3.

3D structure databases

ProteinModelPortali Q5HNF1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176279.SERP1318.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW54646 ; AAW54646 ; SERP1318 .
GeneIDi 3241697.
KEGGi ser:SERP1318.
PATRICi 19613485. VBIStaEpi130894_1285.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci SEPI176279:GJJB-1345-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62A.

Entry informationi

Entry nameiSYL_STAEQ
AccessioniPrimary (citable) accession number: Q5HNF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: February 15, 2005
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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