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Q5HN53 (PTPA_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low molecular weight protein-tyrosine-phosphatase PtpA

EC=3.1.3.48
Alternative name(s):
Phosphotyrosine phosphatase A
Short name=PTPase A
Gene names
Name:ptpA
Ordered Locus Names:SERP1419
OrganismStaphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]
Taxonomic identifier176279 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length154 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Dephosphorylates the phosphotyrosine-containing proteins By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sequence similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Keywords
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 154154Low molecular weight protein-tyrosine-phosphatase PtpA
PRO_0000300667

Sites

Active site81Nucleophile By similarity
Active site141 By similarity
Active site1201Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5HN53 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: AE9E2583CFE9A7DE

FASTA15417,760
        10         20         30         40         50         60 
MIHVAFVCLG NICRSPMAEA IMRQRLQERG ISDIKVHSRG TGRWNLGEPP HNGTQKILQK 

        70         80         90        100        110        120 
YHIPYDGMVS ELFEPDDDFD YIIAMDQSNV DNIKQINPNL QGQLFKLLEF SNMEESDVPD 

       130        140        150 
PYYTNNFEGV FEMVQSSCDN LIDYIVKDAN LKER 

« Hide

References

[1]"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. expand/collapse author list , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000029 Genomic DNA. Translation: AAW54783.1.
RefSeqYP_188988.1. NC_002976.3.

3D structure databases

ProteinModelPortalQ5HN53.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176279.SERP1419.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW54783; AAW54783; SERP1419.
GeneID3241917.
KEGGser:SERP1419.
PATRIC19613767. VBIStaEpi130894_1387.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0394.
HOGENOMHOG000273094.
KOK01104.
OMADSAGTHD.
OrthoDBEOG6MH5JB.

Enzyme and pathway databases

BioCycSEPI176279:GJJB-1483-MONOMER.

Family and domain databases

InterProIPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERPTHR11717. PTHR11717. 1 hit.
PfamPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSPR00719. LMWPTPASE.
SMARTSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMSSF52788. SSF52788. 1 hit.
ProtoNetSearch...

Entry information

Entry namePTPA_STAEQ
AccessionPrimary (citable) accession number: Q5HN53
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families