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Q5HMC7

- TENA_STAEQ

UniProt

Q5HMC7 - TENA_STAEQ

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Protein

Putative thiaminase-2

Gene
tenA, SERP1701
Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Thiamine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441Thiamine By similarity
Active sitei137 – 1371Nucleophile By similarity
Binding sitei141 – 1411Thiamine By similarity
Binding sitei167 – 1671Thiamine By similarity

GO - Molecular functioni

  1. thiaminase activity Source: UniProtKB-EC

GO - Biological processi

  1. thiamine catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Thiamine catabolism

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-1770-MONOMER.
UniPathwayiUPA00841; UER00805.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative thiaminase-2 (EC:3.5.99.2)
Alternative name(s):
Thiaminase II
Gene namesi
Name:tenA
Ordered Locus Names:SERP1701
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000531: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 229229Putative thiaminase-2PRO_0000293616Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP1701.

Structurei

3D structure databases

ProteinModelPortaliQ5HMC7.

Family & Domainsi

Sequence similaritiesi

Belongs to the thiaminase-2 family.

Phylogenomic databases

eggNOGiCOG0819.
HOGENOMiHOG000280169.
KOiK03707.
OMAiVLLPCPW.
OrthoDBiEOG6JMMXP.

Family and domain databases

Gene3Di1.20.910.10. 1 hit.
InterProiIPR016084. Haem_Oase-like_multi-hlx.
IPR004305. Thiaminase-2/PQQC.
IPR027574. Thiaminase_II.
[Graphical view]
PfamiPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMiSSF48613. SSF48613. 1 hit.
TIGRFAMsiTIGR04306. salvage_TenA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HMC7-1 [UniParc]FASTAAdd to Basket

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MTFSKELREA SRPIIDDIYN DGFIQDLLAG KLSNQAVRQY LRADASYLKE    50
FTNIYAMLIP KMSSMEDVKF LVEQIEFMLE GEVEAHEVLA DFINEPYEEI 100
VKEKVWPPSG DHYIKHMYFN AFARENAAFT IAAMAPCPYV YAVIGKRAME 150
DPKLNKESVT SKWFQFYSTE MDELVDVFDQ LMDRLTKHCS ETEKKEIKEN 200
FLQSTIHERH FFNMAYINEK WEYGGNNNE 229
Length:229
Mass (Da):26,900
Last modified:February 15, 2005 - v1
Checksum:iC520C51829A236B2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW55079.1.
RefSeqiYP_189266.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW55079; AAW55079; SERP1701.
GeneIDi3242123.
KEGGiser:SERP1701.
PATRICi19614325. VBIStaEpi130894_1661.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000029 Genomic DNA. Translation: AAW55079.1 .
RefSeqi YP_189266.1. NC_002976.3.

3D structure databases

ProteinModelPortali Q5HMC7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 176279.SERP1701.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAW55079 ; AAW55079 ; SERP1701 .
GeneIDi 3242123.
KEGGi ser:SERP1701.
PATRICi 19614325. VBIStaEpi130894_1661.

Phylogenomic databases

eggNOGi COG0819.
HOGENOMi HOG000280169.
KOi K03707.
OMAi VLLPCPW.
OrthoDBi EOG6JMMXP.

Enzyme and pathway databases

UniPathwayi UPA00841 ; UER00805 .
BioCyci SEPI176279:GJJB-1770-MONOMER.

Family and domain databases

Gene3Di 1.20.910.10. 1 hit.
InterProi IPR016084. Haem_Oase-like_multi-hlx.
IPR004305. Thiaminase-2/PQQC.
IPR027574. Thiaminase_II.
[Graphical view ]
Pfami PF03070. TENA_THI-4. 1 hit.
[Graphical view ]
SUPFAMi SSF48613. SSF48613. 1 hit.
TIGRFAMsi TIGR04306. salvage_TenA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62A.

Entry informationi

Entry nameiTENA_STAEQ
AccessioniPrimary (citable) accession number: Q5HMC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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