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Q5HMC7 (TENA_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative thiaminase-2

EC=3.5.99.2
Alternative name(s):
Thiaminase II
Gene names
Name:tenA
Ordered Locus Names:SERP1701
OrganismStaphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]
Taxonomic identifier176279 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length229 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Thiamine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole.

Pathway

Cofactor metabolism; thiamine degradation; 4-amino-5-hydroxymethyl-2-methylpyrimidine and 5-(2-hydroxyethyl)-4-methylthiazole from thiamine: step 1/1.

Sequence similarities

Belongs to the thiaminase-2 family.

Ontologies

Keywords
   Biological processThiamine catabolism
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processthiamine catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionthiaminase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 229229Putative thiaminase-2
PRO_0000293616

Sites

Active site1371Nucleophile By similarity
Binding site441Thiamine By similarity
Binding site1411Thiamine By similarity
Binding site1671Thiamine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5HMC7 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: C520C51829A236B2

FASTA22926,900
        10         20         30         40         50         60 
MTFSKELREA SRPIIDDIYN DGFIQDLLAG KLSNQAVRQY LRADASYLKE FTNIYAMLIP 

        70         80         90        100        110        120 
KMSSMEDVKF LVEQIEFMLE GEVEAHEVLA DFINEPYEEI VKEKVWPPSG DHYIKHMYFN 

       130        140        150        160        170        180 
AFARENAAFT IAAMAPCPYV YAVIGKRAME DPKLNKESVT SKWFQFYSTE MDELVDVFDQ 

       190        200        210        220 
LMDRLTKHCS ETEKKEIKEN FLQSTIHERH FFNMAYINEK WEYGGNNNE 

« Hide

References

[1]"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. expand/collapse author list , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000029 Genomic DNA. Translation: AAW55079.1.
RefSeqYP_189266.1. NC_002976.3.

3D structure databases

ProteinModelPortalQ5HMC7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING176279.SERP1701.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW55079; AAW55079; SERP1701.
GeneID3242123.
KEGGser:SERP1701.
PATRIC19614325. VBIStaEpi130894_1661.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0819.
HOGENOMHOG000280169.
KOK03707.
OMAVLLPCPW.
OrthoDBEOG6JMMXP.

Enzyme and pathway databases

BioCycSEPI176279:GJJB-1770-MONOMER.
UniPathwayUPA00841; UER00805.

Family and domain databases

Gene3D1.20.910.10. 1 hit.
InterProIPR016084. Haem_Oase-like_multi-hlx.
IPR004305. Thiaminase-2/PQQC.
IPR027574. Thiaminase_II.
[Graphical view]
PfamPF03070. TENA_THI-4. 1 hit.
[Graphical view]
SUPFAMSSF48613. SSF48613. 1 hit.
TIGRFAMsTIGR04306. salvage_TenA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTENA_STAEQ
AccessionPrimary (citable) accession number: Q5HMC7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: February 15, 2005
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways