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Q5HMC7

- TENA_STAEQ

UniProt

Q5HMC7 - TENA_STAEQ

Protein

Putative thiaminase-2

Gene

tenA

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiamine + H2O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei44 – 441ThiamineBy similarity
    Active sitei137 – 1371NucleophileBy similarity
    Binding sitei141 – 1411ThiamineBy similarity
    Binding sitei167 – 1671ThiamineBy similarity

    GO - Molecular functioni

    1. thiaminase activity Source: UniProtKB-EC

    GO - Biological processi

    1. thiamine catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Thiamine catabolism

    Enzyme and pathway databases

    BioCyciSEPI176279:GJJB-1770-MONOMER.
    UniPathwayiUPA00841; UER00805.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative thiaminase-2 (EC:3.5.99.2)
    Alternative name(s):
    Thiaminase II
    Gene namesi
    Name:tenA
    Ordered Locus Names:SERP1701
    OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
    Taxonomic identifieri176279 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000531: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 229229Putative thiaminase-2PRO_0000293616Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi176279.SERP1701.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5HMC7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thiaminase-2 family.Curated

    Phylogenomic databases

    eggNOGiCOG0819.
    HOGENOMiHOG000280169.
    KOiK03707.
    OMAiVLLPCPW.
    OrthoDBiEOG6JMMXP.

    Family and domain databases

    Gene3Di1.20.910.10. 1 hit.
    InterProiIPR016084. Haem_Oase-like_multi-hlx.
    IPR004305. Thiaminase-2/PQQC.
    IPR027574. Thiaminase_II.
    [Graphical view]
    PfamiPF03070. TENA_THI-4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48613. SSF48613. 1 hit.
    TIGRFAMsiTIGR04306. salvage_TenA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5HMC7-1 [UniParc]FASTAAdd to Basket

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    MTFSKELREA SRPIIDDIYN DGFIQDLLAG KLSNQAVRQY LRADASYLKE    50
    FTNIYAMLIP KMSSMEDVKF LVEQIEFMLE GEVEAHEVLA DFINEPYEEI 100
    VKEKVWPPSG DHYIKHMYFN AFARENAAFT IAAMAPCPYV YAVIGKRAME 150
    DPKLNKESVT SKWFQFYSTE MDELVDVFDQ LMDRLTKHCS ETEKKEIKEN 200
    FLQSTIHERH FFNMAYINEK WEYGGNNNE 229
    Length:229
    Mass (Da):26,900
    Last modified:February 15, 2005 - v1
    Checksum:iC520C51829A236B2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000029 Genomic DNA. Translation: AAW55079.1.
    RefSeqiYP_189266.1. NC_002976.3.

    Genome annotation databases

    EnsemblBacteriaiAAW55079; AAW55079; SERP1701.
    GeneIDi3242123.
    KEGGiser:SERP1701.
    PATRICi19614325. VBIStaEpi130894_1661.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000029 Genomic DNA. Translation: AAW55079.1 .
    RefSeqi YP_189266.1. NC_002976.3.

    3D structure databases

    ProteinModelPortali Q5HMC7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 176279.SERP1701.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW55079 ; AAW55079 ; SERP1701 .
    GeneIDi 3242123.
    KEGGi ser:SERP1701.
    PATRICi 19614325. VBIStaEpi130894_1661.

    Phylogenomic databases

    eggNOGi COG0819.
    HOGENOMi HOG000280169.
    KOi K03707.
    OMAi VLLPCPW.
    OrthoDBi EOG6JMMXP.

    Enzyme and pathway databases

    UniPathwayi UPA00841 ; UER00805 .
    BioCyci SEPI176279:GJJB-1770-MONOMER.

    Family and domain databases

    Gene3Di 1.20.910.10. 1 hit.
    InterProi IPR016084. Haem_Oase-like_multi-hlx.
    IPR004305. Thiaminase-2/PQQC.
    IPR027574. Thiaminase_II.
    [Graphical view ]
    Pfami PF03070. TENA_THI-4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48613. SSF48613. 1 hit.
    TIGRFAMsi TIGR04306. salvage_TenA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
      Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
      , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
      J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35984 / RP62A.

    Entry informationi

    Entry nameiTENA_STAEQ
    AccessioniPrimary (citable) accession number: Q5HMC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3