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Protein

Low molecular weight protein-tyrosine-phosphatase PtpB

Gene

ptpB

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Dephosphorylates the phosphotyrosine-containing proteins.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei7NucleophileBy similarity1
Active sitei13By similarity1
Active sitei111Proton donorBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Low molecular weight protein-tyrosine-phosphatase PtpB (EC:3.1.3.48)
Alternative name(s):
Phosphotyrosine phosphatase B
Short name:
PTPase B
Gene namesi
Name:ptpB
Ordered Locus Names:SERP1721
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000531 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003006811 – 139Low molecular weight protein-tyrosine-phosphatase PtpBAdd BLAST139

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP1721.

Structurei

3D structure databases

ProteinModelPortaliQ5HMA8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107WAU. Bacteria.
COG0394. LUCA.
HOGENOMiHOG000273091.
KOiK01104.
OMAiSIDIYKQ.

Family and domain databases

CDDicd00115. LMWPc. 1 hit.
InterProiIPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF14. PTHR11717:SF14. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HMA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIIFVCSGN TCRSPLAESI AKSLLPHDSI ASRGLFAVEG QAISKESLEL
60 70 80 90 100
IHKYDLPEPS RAQAFHIDDL DADIILTMTQ AHKDLIFSMY GRQSNVFTLN
110 120 130
EYVGDTQEID DPFGGSFDVY EQTYTKIYDL VDKIKFKHE
Length:139
Mass (Da):15,709
Last modified:February 15, 2005 - v1
Checksum:i1E389CBAB81BA0C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW55121.1.
RefSeqiWP_002457126.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW55121; AAW55121; SERP1721.
KEGGiser:SERP1721.
PATRICi19614365. VBIStaEpi130894_1681.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW55121.1.
RefSeqiWP_002457126.1. NC_002976.3.

3D structure databases

ProteinModelPortaliQ5HMA8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176279.SERP1721.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW55121; AAW55121; SERP1721.
KEGGiser:SERP1721.
PATRICi19614365. VBIStaEpi130894_1681.

Phylogenomic databases

eggNOGiENOG4107WAU. Bacteria.
COG0394. LUCA.
HOGENOMiHOG000273091.
KOiK01104.
OMAiSIDIYKQ.

Family and domain databases

CDDicd00115. LMWPc. 1 hit.
InterProiIPR023485. Ptyr_pPase_SF.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERiPTHR11717:SF14. PTHR11717:SF14. 1 hit.
PfamiPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSiPR00719. LMWPTPASE.
SMARTiSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMiSSF52788. SSF52788. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPTPB_STAEQ
AccessioniPrimary (citable) accession number: Q5HMA8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.