Reviewed, UniProtKB/Swiss-Prot Q5HMA0 (ALD1_STAEQ)

Names and origin

Protein names

Recommended name:
    Putative aldehyde dehydrogenase SERP1729
    EC=1.2.1.3

Gene names

Ordered Locus Names:

SERP1729

Organism

Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]

Taxonomic identifier

176279 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	475 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD(+) + H(2)O = an acid + NADH.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 475	475	Putative aldehyde dehydrogenase SERP1729		PRO_0000293562
Regions
	Nucleotide binding	201 – 207	7	NAD By similarity
Sites
	Active site	245	1	By similarity
	Active site	279	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5HMA0-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: 905E024191EE75D1	FASTA	475	51,890
	10 20 30 40 50 60 MRNFTKQYIN GEWVDSASGE TIDVINPATE EVMGKIAKGN EEDVNKAVDA ADKVYLEFRH 70 80 90 100 110 120 SSVEERRELL DKIVKEYQNR KNDLIEAITD ELGAPLSVSE NVHYQMGLNH FTAARDALDS 130 140 150 160 170 180 FQFEEQRGDD LVVKEAIGVA GLVTPWNFPT NQTSLKLAAA FAAGSPVVLK PSEETPFAAI 190 200 210 220 230 240 ILAEIFDKVG VPKGVFNLVN GDGSGVGNPL SEHPKVRMMS FTGSGPTGSK IMEKAAKDFK 250 260 270 280 290 300 KVSLELGGKS PYIVLDDVDV EEAANATTKK VVNNTGQVCT AGTRVLIPES IKEDYLTAVK 310 320 330 340 350 360 EAFSKVKVGQ PREEGTQVGP IISKKQFDQV QDYIDKGINE GAELFYGGPG KPEGLDKGYF 370 380 390 400 410 420 ARPTIFINVD NHMTIAQEEI FGPVMSVITY NNLDEAIEIA NDTKYGLAGY VIGKDKDTLR 430 440 450 460 470 HVARSIEAGT IEINEAGRKP DLPFGGYKES GLGREWGDYG IEEFLEVKSI AGYFK

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000029 Genomic DNA. Translation: AAW55043.1.
RefSeq	YP_189293.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3242710.
GenomeReviews	Gene locus SERP1729 in contig CP000029_GR.
KEGG	ser:SERP1729.
TIGR	SERP1729.
Phylogenomic databases
HOGENOM	Q5HMA0.
Enzyme and pathway databases
BioCyc	SEPI176279:SERP1729-MON.
Family and domain databases
InterPro	IPR016160. Ald_DHase_CS. IPR016162. Ald_DHase_N. IPR015590. Aldehyde_DHase. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALD1_STAEQ

Accession

Primary (citable) accession number: Q5HMA0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	February 15, 2005
Last modified:	November 4, 2008
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)