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Q5HM36 (LACB_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Galactose-6-phosphate isomerase subunit LacB
EC=5.3.1.26
Gene names
Name:lacB
Ordered Locus Names:SERP1794
OrganismStaphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]
Taxonomic identifier176279 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length171 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-galactose 6-phosphate = D-tagatose 6-phosphate. HAMAP-Rule MF_01556

Pathway

Carbohydrate metabolism; D-galactose 6-phosphate degradation; D-tagatose 6-phosphate from D-galactose 6-phosphate: step 1/1. HAMAP-Rule MF_01556

Subunit structure

Heteromultimeric protein consisting of LacA and LacB By similarity.

Sequence similarities

Belongs to the LacAB/RpiB family.

Ontologies

Keywords
   Biological processLactose metabolism
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgalactose catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

lactose catabolic process via tagatose-6-phosphate

Inferred from electronic annotation. Source: HAMAP

   Molecular_functiongalactose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 171171Galactose-6-phosphate isomerase subunit LacB HAMAP-Rule MF_01556
PRO_0000208144

Sequences

Sequence LengthMass (Da)Tools
Q5HM36 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 0CF3B0A59420B477

FASTA17118,903
        10         20         30         40         50         60 
MKIAIGCDHI VTDTKMEVSQ HLKSQGHEVI DVGTYDFTRT HYPIYGKKVG EKVASGEADL 

        70         80         90        100        110        120 
GVCICGTGVG ISNAANKVPG VRTALVRDMT SALYSKEELN ANVVSFGGKV AGELFIFDIV 

       130        140        150        160        170 
DAFIEAEYKP TEENKKLIAK INHLEAHNND QADPHFFDEF LEKWNKGEYH D

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References

[1]"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. expand/collapse author list , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000029 Genomic DNA. Translation: AAW55179.1.
RefSeqYP_189357.1. NC_002976.3.

3D structure databases

ProteinModelPortalQ5HM36.
ModBaseSearch...

Protein-protein interaction databases

STRING176279.SERP1794.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW55179; AAW55179; SERP1794.
GeneID3241278.
KEGGser:SERP1794.
PATRIC19614524. VBIStaEpi130894_1751.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0698.
HOGENOMHOG000226301.
KOK01819.
OMAETHHANQ.
ProtClustDBPRK08622.

Enzyme and pathway databases

BioCycSEPI176279:GJJB-1872-MONOMER.
UniPathwayUPA00702; UER00714.

Family and domain databases

Gene3D3.40.1400.10. 1 hit.
HAMAPMF_01556. LacB.
InterProIPR004784. LacB.
IPR003500. Rib/Gal_isomrase.
[Graphical view]
PANTHERPTHR30345. PTHR30345. 1 hit.
PfamPF02502. LacAB_rpiB. 1 hit.
[Graphical view]
PIRSFPIRSF005384. RpiB_LacA_B. 1 hit.
SUPFAMSSF89623. Rib/Gal_isomrase. 1 hit.
TIGRFAMsTIGR01119. lacB. 1 hit.
TIGR00689. rpiB_lacA_lacB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLACB_STAEQ
AccessionPrimary (citable) accession number: Q5HM36
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: February 15, 2005
Last modified: May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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