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Q5HLN6 (Q5HLN6_STAEQ) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:tcaR EMBL AAW52831.1
Ordered Locus Names:SERP1949 EMBL AAW52831.1
OrganismStaphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP] EMBL AAW52831.1
Taxonomic identifier176279 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length151 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region37 – 404Cacodylate 1 binding PDB 3KP6
Region38 – 425Kanamycin 2 binding
Region70 – 745Cacodylate 1 binding PDB 3KP6

Sites

Binding site171Kanamycin 1
Binding site201Kanamycin 2
Binding site311Kanamycin 2
Binding site611Kanamycin 1; via carbonyl oxygen
Binding site611Kanamycin 2
Binding site661Kanamycin 3; via carbonyl oxygen
Binding site701Kanamycin 3
Binding site741Kanamycin 3
Binding site1011Cacodylate 2 PDB 3KP2
Binding site1101Kanamycin 2

Sequences

Sequence LengthMass (Da)Tools
Q5HLN6 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: 600536DFEFD5399D

FASTA15117,348
        10         20         30         40         50         60 
MVRRIEDHIS FLEKFINDVN TLTAKLLKDL QTEYGISAEQ SHVLNMLSIE ALTVGQITEK 

        70         80         90        100        110        120 
QGVNKAAVSR RVKKLLNAEL VKLEKPDSNT DQRLKIIKLS NKGKKYIKER KAIMSHIASD 

       130        140        150 
MTSDFDSKEI EKVRQVLEII DYRIQSYTSK L 

« Hide

References

« Hide 'large scale' references
[1]"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., Deboy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L., Beanan M., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J., Khouri H. expand/collapse author list , Utterback T., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K., Hance I.R., Nelson K.E., Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35984 / RP62A.
[2]"Structural study of TcaR and its complexes with multiple antibiotics from Staphylococcus epidermidis."
Chang Y.M., Jeng W.Y., Ko T.P., Yeh Y.J., Chen C.K., Wang A.H.
Proc. Natl. Acad. Sci. U.S.A. 107:8617-8622(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH CACODYLATE AND KANAMYCIN.
[3]"Functional studies of ssDNA binding ability of MarR family protein TcaR from Staphylococcus epidermidis."
Chang Y.M., Chen C.K., Chang Y.C., Jeng W.Y., Hou M.H., Wang A.H.
PLoS ONE 7:e45665-e45665(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000029 Genomic DNA. Translation: AAW52831.1.
RefSeqYP_189507.1. NC_002976.3.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3KP2X-ray2.55A/B1-151[»]
3KP3X-ray3.20A/B1-151[»]
3KP4X-ray2.84A/B1-151[»]
3KP5X-ray3.00A/B1-151[»]
3KP6X-ray2.45A/B1-151[»]
3KP7X-ray2.30A/B1-151[»]
4EJTX-ray3.00A/B1-151[»]
4EJUX-ray2.40A/B1-151[»]
4EJVX-ray2.90A/B1-151[»]
4EJWX-ray2.80A/B1-151[»]
ProteinModelPortalQ5HLN6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-59325N.
STRING176279.SERP1949.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAW52831; AAW52831; SERP1949.
GeneID3242456.
KEGGser:SERP1949.
PATRIC19614818. VBIStaEpi130894_1898.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGNOG85258.
HOGENOMHOG000280237.
OMAMKQFIDD.
OrthoDBEOG6091DT.

Enzyme and pathway databases

BioCycSEPI176279:GJJB-2026-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR000835. HTH_MarR-typ.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
SMARTSM00347. HTH_MARR. 1 hit.
[Graphical view]
PROSITEPS50995. HTH_MARR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ5HLN6.

Entry information

Entry nameQ5HLN6_STAEQ
AccessionPrimary (citable) accession number: Q5HLN6
Entry history
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)