Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Transcriptional regulator TcaR

Gene

tcaR

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-2026-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Transcriptional regulator TcaRImported
Gene namesi
Name:tcaRImported
Ordered Locus Names:SERP1949Imported
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)Imported
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000000531: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Interactioni

Protein-protein interaction databases

DIPiDIP-59325N.
STRINGi176279.SERP1949.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KP2X-ray2.55A/B1-151[»]
3KP3X-ray3.20A/B1-151[»]
3KP4X-ray2.84A/B1-151[»]
3KP5X-ray3.00A/B1-151[»]
3KP6X-ray2.45A/B1-151[»]
3KP7X-ray2.30A/B1-151[»]
4EJTX-ray3.00A/B1-151[»]
4EJUX-ray2.40A/B1-151[»]
4EJVX-ray2.90A/B1-151[»]
4EJWX-ray2.80A/B1-151[»]
ProteinModelPortaliQ5HLN6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5HLN6.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG85258.
HOGENOMiHOG000280237.
OMAiMKQFIDD.
OrthoDBiEOG6091DT.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000835. HTH_MarR-typ.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
SMARTiSM00347. HTH_MARR. 1 hit.
[Graphical view]
PROSITEiPS50995. HTH_MARR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5HLN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRRIEDHIS FLEKFINDVN TLTAKLLKDL QTEYGISAEQ SHVLNMLSIE
60 70 80 90 100
ALTVGQITEK QGVNKAAVSR RVKKLLNAEL VKLEKPDSNT DQRLKIIKLS
110 120 130 140 150
NKGKKYIKER KAIMSHIASD MTSDFDSKEI EKVRQVLEII DYRIQSYTSK

L
Length:151
Mass (Da):17,348
Last modified:February 15, 2005 - v1
Checksum:i600536DFEFD5399D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW52831.1.
RefSeqiYP_189507.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW52831; AAW52831; SERP1949.
GeneIDi3242456.
KEGGiser:SERP1949.
PATRICi19614818. VBIStaEpi130894_1898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW52831.1.
RefSeqiYP_189507.1. NC_002976.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KP2X-ray2.55A/B1-151[»]
3KP3X-ray3.20A/B1-151[»]
3KP4X-ray2.84A/B1-151[»]
3KP5X-ray3.00A/B1-151[»]
3KP6X-ray2.45A/B1-151[»]
3KP7X-ray2.30A/B1-151[»]
4EJTX-ray3.00A/B1-151[»]
4EJUX-ray2.40A/B1-151[»]
4EJVX-ray2.90A/B1-151[»]
4EJWX-ray2.80A/B1-151[»]
ProteinModelPortaliQ5HLN6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59325N.
STRINGi176279.SERP1949.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW52831; AAW52831; SERP1949.
GeneIDi3242456.
KEGGiser:SERP1949.
PATRICi19614818. VBIStaEpi130894_1898.

Phylogenomic databases

eggNOGiNOG85258.
HOGENOMiHOG000280237.
OMAiMKQFIDD.
OrthoDBiEOG6091DT.

Enzyme and pathway databases

BioCyciSEPI176279:GJJB-2026-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ5HLN6.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR000835. HTH_MarR-typ.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
SMARTiSM00347. HTH_MARR. 1 hit.
[Graphical view]
PROSITEiPS50995. HTH_MARR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
    Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
    , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
    J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35984 / RP62AImported.
  2. "Structural study of TcaR and its complexes with multiple antibiotics from Staphylococcus epidermidis."
    Chang Y.M., Jeng W.Y., Ko T.P., Yeh Y.J., Chen C.K., Wang A.H.
    Proc. Natl. Acad. Sci. U.S.A. 107:8617-8622(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).
  3. "Functional studies of ssDNA binding ability of MarR family protein TcaR from Staphylococcus epidermidis."
    Chang Y.M., Chen C.K., Chang Y.C., Jeng W.Y., Hou M.H., Wang A.H.
    PLoS ONE 7:e45665-e45665(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS).

Entry informationi

Entry nameiQ5HLN6_STAEQ
AccessioniPrimary (citable) accession number: Q5HLN6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 15, 2005
Last sequence update: February 15, 2005
Last modified: January 7, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.