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Q5HLN6

- Q5HLN6_STAEQ

UniProt

Q5HLN6 - Q5HLN6_STAEQ

Protein
Submitted name:

Transcriptional regulator TcaR

Gene

tcaR

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (15 Feb 2005)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei17 – 171Kanamycin 1
    Binding sitei20 – 201Kanamycin 2
    Binding sitei31 – 311Kanamycin 2
    Binding sitei61 – 611Kanamycin 1; via carbonyl oxygen
    Binding sitei61 – 611Kanamycin 2
    Binding sitei66 – 661Kanamycin 3; via carbonyl oxygen
    Binding sitei70 – 701Kanamycin 3
    Binding sitei74 – 741Kanamycin 3
    Binding sitei101 – 1011Cacodylate 2Imported
    Binding sitei110 – 1101Kanamycin 2

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro

    Enzyme and pathway databases

    BioCyciSEPI176279:GJJB-2026-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Transcriptional regulator TcaRImported
    Gene namesi
    Name:tcaRImported
    Ordered Locus Names:SERP1949Imported
    OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)Imported
    Taxonomic identifieri176279 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000000531: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-59325N.
    STRINGi176279.SERP1949.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3KP2X-ray2.55A/B1-151[»]
    3KP3X-ray3.20A/B1-151[»]
    3KP4X-ray2.84A/B1-151[»]
    3KP5X-ray3.00A/B1-151[»]
    3KP6X-ray2.45A/B1-151[»]
    3KP7X-ray2.30A/B1-151[»]
    4EJTX-ray3.00A/B1-151[»]
    4EJUX-ray2.40A/B1-151[»]
    4EJVX-ray2.90A/B1-151[»]
    4EJWX-ray2.80A/B1-151[»]
    ProteinModelPortaliQ5HLN6.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ5HLN6.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni37 – 404Cacodylate 1 bindingImported
    Regioni38 – 425Kanamycin 2 binding
    Regioni70 – 745Cacodylate 1 bindingImported

    Phylogenomic databases

    eggNOGiNOG85258.
    HOGENOMiHOG000280237.
    OMAiMKQFIDD.
    OrthoDBiEOG6091DT.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR000835. HTH_MarR-typ.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    SMARTiSM00347. HTH_MARR. 1 hit.
    [Graphical view]
    PROSITEiPS50995. HTH_MARR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5HLN6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVRRIEDHIS FLEKFINDVN TLTAKLLKDL QTEYGISAEQ SHVLNMLSIE    50
    ALTVGQITEK QGVNKAAVSR RVKKLLNAEL VKLEKPDSNT DQRLKIIKLS 100
    NKGKKYIKER KAIMSHIASD MTSDFDSKEI EKVRQVLEII DYRIQSYTSK 150
    L 151
    Length:151
    Mass (Da):17,348
    Last modified:February 15, 2005 - v1
    Checksum:i600536DFEFD5399D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000029 Genomic DNA. Translation: AAW52831.1.
    RefSeqiYP_189507.1. NC_002976.3.

    Genome annotation databases

    EnsemblBacteriaiAAW52831; AAW52831; SERP1949.
    GeneIDi3242456.
    KEGGiser:SERP1949.
    PATRICi19614818. VBIStaEpi130894_1898.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000029 Genomic DNA. Translation: AAW52831.1 .
    RefSeqi YP_189507.1. NC_002976.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3KP2 X-ray 2.55 A/B 1-151 [» ]
    3KP3 X-ray 3.20 A/B 1-151 [» ]
    3KP4 X-ray 2.84 A/B 1-151 [» ]
    3KP5 X-ray 3.00 A/B 1-151 [» ]
    3KP6 X-ray 2.45 A/B 1-151 [» ]
    3KP7 X-ray 2.30 A/B 1-151 [» ]
    4EJT X-ray 3.00 A/B 1-151 [» ]
    4EJU X-ray 2.40 A/B 1-151 [» ]
    4EJV X-ray 2.90 A/B 1-151 [» ]
    4EJW X-ray 2.80 A/B 1-151 [» ]
    ProteinModelPortali Q5HLN6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-59325N.
    STRINGi 176279.SERP1949.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAW52831 ; AAW52831 ; SERP1949 .
    GeneIDi 3242456.
    KEGGi ser:SERP1949.
    PATRICi 19614818. VBIStaEpi130894_1898.

    Phylogenomic databases

    eggNOGi NOG85258.
    HOGENOMi HOG000280237.
    OMAi MKQFIDD.
    OrthoDBi EOG6091DT.

    Enzyme and pathway databases

    BioCyci SEPI176279:GJJB-2026-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q5HLN6.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR000835. HTH_MarR-typ.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    SMARTi SM00347. HTH_MARR. 1 hit.
    [Graphical view ]
    PROSITEi PS50995. HTH_MARR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
      Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H.
      , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
      J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35984 / RP62AImported.
    2. "Structural study of TcaR and its complexes with multiple antibiotics from Staphylococcus epidermidis."
      Chang Y.M., Jeng W.Y., Ko T.P., Yeh Y.J., Chen C.K., Wang A.H.
      Proc. Natl. Acad. Sci. U.S.A. 107:8617-8622(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).
    3. "Functional studies of ssDNA binding ability of MarR family protein TcaR from Staphylococcus epidermidis."
      Chang Y.M., Chen C.K., Chang Y.C., Jeng W.Y., Hou M.H., Wang A.H.
      PLoS ONE 7:e45665-e45665(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS).

    Entry informationi

    Entry nameiQ5HLN6_STAEQ
    AccessioniPrimary (citable) accession number: Q5HLN6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 15, 2005
    Last sequence update: February 15, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3