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Protein

Probable malate:quinone oxidoreductase 1

Gene

mqo1

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase 4 (mqo4), Probable malate:quinone oxidoreductase 3 (mqo3), Probable malate:quinone oxidoreductase 2 (mqo2), Probable malate:quinone oxidoreductase 1 (mqo1)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductase 1UniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQO 1UniRule annotation
Malate dehydrogenase [quinone] 1UniRule annotation
Gene namesi
Name:mqo1UniRule annotation
Ordered Locus Names:SERP1955
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000531 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001287531 – 492Probable malate:quinone oxidoreductase 1Add BLAST492

Proteomic databases

PRIDEiQ5HLN0.

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP1955.

Structurei

3D structure databases

ProteinModelPortaliQ5HLN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
KOiK00116.
OMAiEPIAATK.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HLN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTQHSKTDV ILIGGGIMSA TLGTLLKELT PEKDIQLFER LSQPGEESSN
60 70 80 90 100
VWNNAGTGHS ALCELNYTKE GKDGSVDITK AIHINEQFQI SKQFWAYLIR
110 120 130 140 150
EGHIESPDKF IQSVPHMSFV KGEENVKFLK SRVASLQKNV LFEKMKISQD
160 170 180 190 200
PEKINSWVPL MMEGRQSDEA IAITYDETGT DVNFGALTKK LIANLQQKNV
210 220 230 240 250
GINYKHEVLD IKKLNNGNWQ VVVKDLNTSN VMNYESKFVF IGAGGASLPL
260 270 280 290 300
LQKTKIKESK HIGGFPVSGL FLRCKNPDVI HRHHAKVYGK AEVGAPPMSV
310 320 330 340 350
PHLDTRFVNG EKSLLFGPFA GFSPKFLKNG SYLDLVKSVK PNNMITMLSA
360 370 380 390 400
GVKEFNLTKY LVSQLMLSNE ERINDLRVFL PEAKDEDWEV ITAGQRVQVI
410 420 430 440 450
KDTDKSKGQL QFGTEVITSE DGSLAALLGA SPGASTAVDI MFDVLQRCYK
460 470 480 490
SEFKSWEPKI KEMVPSFGLK LSEHEDMYHS INEEVKKYLN VK
Length:492
Mass (Da):55,032
Last modified:February 15, 2005 - v1
Checksum:iA0791686F3969AD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW52837.1.
RefSeqiWP_001831551.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW52837; AAW52837; SERP1955.
KEGGiser:SERP1955.
PATRICi19614830. VBIStaEpi130894_1904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW52837.1.
RefSeqiWP_001831551.1. NC_002976.3.

3D structure databases

ProteinModelPortaliQ5HLN0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi176279.SERP1955.

Proteomic databases

PRIDEiQ5HLN0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAW52837; AAW52837; SERP1955.
KEGGiser:SERP1955.
PATRICi19614830. VBIStaEpi130894_1904.

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
KOiK00116.
OMAiEPIAATK.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO. 1 hit.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMQO1_STAEQ
AccessioniPrimary (citable) accession number: Q5HLN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: February 15, 2005
Last modified: November 2, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.