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Protein

Polyphosphate kinase

Gene

ppk

Organism
Staphylococcus epidermidis (strain ATCC 35984 / RP62A)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).UniRule annotation

Catalytic activityi

ATP + (phosphate)(n) = ADP + (phosphate)(n+1).UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54ATPUniRule annotation1
Metal bindingi379MagnesiumUniRule annotation1
Metal bindingi409MagnesiumUniRule annotation1
Active sitei439Phosphohistidine intermediateUniRule annotation1
Binding sitei472ATPUniRule annotation1
Binding sitei568ATPUniRule annotation1
Binding sitei596ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyphosphate kinaseUniRule annotation (EC:2.7.4.1UniRule annotation)
Alternative name(s):
ATP-polyphosphate phosphotransferaseUniRule annotation
Polyphosphoric acid kinaseUniRule annotation
Gene namesi
Name:ppkUniRule annotation
Ordered Locus Names:SERP2047
OrganismiStaphylococcus epidermidis (strain ATCC 35984 / RP62A)
Taxonomic identifieri176279 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Proteomesi
  • UP000000531 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001286581 – 721Polyphosphate kinaseAdd BLAST721

Post-translational modificationi

An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi176279.SERP2047.

Structurei

3D structure databases

ProteinModelPortaliQ5HLE0.
SMRiQ5HLE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini434 – 468PLD phosphodiesteraseUniRule annotationAdd BLAST35

Sequence similaritiesi

Belongs to the polyphosphate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CUU. Bacteria.
COG0855. LUCA.
HOGENOMiHOG000248948.
KOiK00937.
OMAiQIMVANL.

Family and domain databases

Gene3Di3.30.1840.10. 1 hit.
HAMAPiMF_00347. Polyphosphate_kinase. 1 hit.
InterProiView protein in InterPro
IPR003414. PP_kinase.
IPR024953. PP_kinase_middle.
IPR025200. PPK_C_dom.
IPR025198. PPK_N_dom.
PfamiView protein in Pfam
PF02503. PP_kinase. 1 hit.
PF13090. PP_kinase_C. 1 hit.
PF13089. PP_kinase_N. 1 hit.
PIRSFiPIRSF015589. PP_kinase. 1 hit.
SUPFAMiSSF140356. SSF140356. 1 hit.
TIGRFAMsiTIGR03705. poly_P_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5HLE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTRLGEKDI NLPQYYNNRE LSWLDFNYRV LQESYDKNNP LLEKLNFISI
60 70 80 90 100
FSSNLDEFFM VRVAGLKDQV KMGYDKPENK AQMTPQEQLD AIKIKNTDYV
110 120 130 140 150
NTQYQRYNEL IKELANYDIE MVKPEDLSDA LIEKLEQEFK LSVLPTLTPL
160 170 180 190 200
GIDAYHPFPK LNNKSLNIFV DIDTEDAINS AIVQIPSLIP RFLTLNEGTK
210 220 230 240 250
QYVVMVEDVI TYFINYLFTG YEVLNTFTFR ITRNADLTIH EDGAEDLLIE
260 270 280 290 300
IERFLKERKS GSAVRLELDC RTSEKENVEW LINQLEIEDN DIYYLDGPLD
310 320 330 340 350
LTFLFGLVDH LSHKLKYLTY EKYTPQPPRS LGNKNIYQLS LERDIFFHHP
360 370 380 390 400
YESFEPIVDF IRQAADDPNT IAIKQTLYRV SKDSPIINSL KEAAENGKQV
410 420 430 440 450
TVLVELKARF DEENNVHWAR MLEDAGCHVI YGMTHLKTHS KIALVVKRIN
460 470 480 490 500
NELTSFVHLG TGNYNDKTAK LYTDMGIITT NKDIAEDAIN FFNYLSGYST
510 520 530 540 550
KPEYNKLIVA PYDIRDVFID RIDKEIRSHL QHGNGKIMMK MNSLTDKTII
560 570 580 590 600
EKLFEASQAG VKIQLIIRGI CCLKPGIPGI SENIEVVSIV GRLLEHSRIY
610 620 630 640 650
YFHNNSEAHI YLSSADVMTR NMIKRVEILF PVEDKSIGQR LVNYMNLQLS
660 670 680 690 700
DNQKGRYQDA QGLYHYVENN SSPLNSQSYL MQEAIKYGEE LKKQSVQPSG
710 720
QPVHSRRGGS WMRKLKNTFK R
Length:721
Mass (Da):83,566
Last modified:February 15, 2005 - v1
Checksum:iEC0EB0BF47E1DF44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000029 Genomic DNA. Translation: AAW52887.1.
RefSeqiWP_002456043.1. NC_002976.3.

Genome annotation databases

EnsemblBacteriaiAAW52887; AAW52887; SERP2047.
KEGGiser:SERP2047.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPPK_STAEQ
AccessioniPrimary (citable) accession number: Q5HLE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 15, 2005
Last modified: June 7, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families