Reviewed, UniProtKB/Swiss-Prot Q5HLD1 (GTAB_STAEQ)

Names and origin

Protein names

Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase
    EC=2.7.7.9
Alternative name(s):
    UDP-glucose pyrophosphorylase
      Short name=UDPGP
    Alpha-D-glucosyl-1-phosphate uridylyltransferase
    Uridine diphosphoglucose pyrophosphorylase

Gene names

Name:	gtaB
Synonyms:	galU
Ordered Locus Names:	SERP2056

Organism

Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]

Taxonomic identifier

176279 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) By similarity.
Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Pathway	Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis.
Sequence similarities	Belongs to the UDPGP type 2 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	UTP--glucose-1-phosphate uridylyltransferase		PRO_0000308310

Sequences

	Sequence		Length	Mass (Da)
	Q5HLD1-1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: ED5422E73E60672F	FASTA	288	32,424
	10 20 30 40 50 60 MKKIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEASKAGI EDIIIVTGKH 70 80 90 100 110 120 KRAIEDHFDN QKELEMVLEN KGKADLLEKV QYSTDLANIF YVRQKEQKGL GHAIHTAKQF 130 140 150 160 170 180 IGNEPFAVLL GDDIVESDTP AIKQLMDVYE ETGHSVIGVQ EVPESDTHRY GVIDPSAKEG 190 200 210 220 230 240 SRYEVRQFVE KPKQGTAPSN LAIMGRYVLT PEIFDYLETQ QEGAGNEIQL TDAIERMNSK 250 260 270 280 QQVYAYDFEG NRYDVGEKLG FVKTTIEYAL KDPEMSQDLK AFIKQLDI

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000029 Genomic DNA. Translation: AAW52903.1.
RefSeq	YP_189612.1.
3D structure databases
HSSP	HSSP built from PDB template 1IIN based on UniProtKB P26393.
SMR	Q5HLD1. Positions 2-285.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5HLD1.
Genome annotation databases
GeneID	3242255.
GenomeReviews	Gene locus SERP2056 in contig CP000029_GR.
KEGG	ser:SERP2056.
TIGR	SERP2056.
Phylogenomic databases
eggNOG	COG1210.
HOGENOM	HBG688195.
OMA	NERRYQV.
Enzyme and pathway databases
BioCyc	SEPI176279:SERP2056-MONOMER.
Family and domain databases
InterPro	IPR005771. GalU_uridylyltTrfase_bac/arc. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01099. galU. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GTAB_STAEQ

Accession

Primary (citable) accession number: Q5HLD1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	February 15, 2005
Last modified:	February 9, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)