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Reviewed, UniProtKB/Swiss-Prot Q5HLD1 (GTAB_STAEQ)

Last modified February 9, 2010. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    UTP--glucose-1-phosphate uridylyltransferase
    EC=2.7.7.9
Alternative name(s):
    UDP-glucose pyrophosphorylase
      Short name=UDPGP
    Alpha-D-glucosyl-1-phosphate uridylyltransferase
    Uridine diphosphoglucose pyrophosphorylase
Gene names
Name: gtaB
Synonyms: galU
Ordered Locus Names: SERP2056
OrganismStaphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]
Taxonomic identifier176279 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacillalesStaphylococcus

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) By similarity.

Catalytic activity

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathway

Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis.

Sequence similarities

Belongs to the UDPGP type 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288UTP--glucose-1-phosphate uridylyltransferase
PRO_0000308310

Sequences

Sequence LengthMass (Da)Tools
Q5HLD1-1 [UniParc].

Last modified February 15, 2005. Version 1.
Checksum: ED5422E73E60672F

FASTA28832,424
        10         20         30         40         50         60 
MKKIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEASKAGI EDIIIVTGKH 

        70         80         90        100        110        120 
KRAIEDHFDN QKELEMVLEN KGKADLLEKV QYSTDLANIF YVRQKEQKGL GHAIHTAKQF 

       130        140        150        160        170        180 
IGNEPFAVLL GDDIVESDTP AIKQLMDVYE ETGHSVIGVQ EVPESDTHRY GVIDPSAKEG 

       190        200        210        220        230        240 
SRYEVRQFVE KPKQGTAPSN LAIMGRYVLT PEIFDYLETQ QEGAGNEIQL TDAIERMNSK 

       250        260        270        280 
QQVYAYDFEG NRYDVGEKLG FVKTTIEYAL KDPEMSQDLK AFIKQLDI 

« Hide

References

[1]"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain."
Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. expand/collapse author list , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M.
J. Bacteriol. 187:2426-2438(2005) [PubMed: 15774886] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000029 Genomic DNA. Translation: AAW52903.1.
RefSeqYP_189612.1.

3D structure databases

HSSPHSSP built from PDB template 1IIN based on UniProtKB P26393.
SMRQ5HLD1. Positions 2-285.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5HLD1.

Genome annotation databases

GeneID3242255.
GenomeReviewsGene locus SERP2056 in contig CP000029_GR.
KEGGser:SERP2056.
TIGRSERP2056.

Phylogenomic databases

eggNOGCOG1210.
HOGENOMHBG688195.
OMANERRYQV.

Enzyme and pathway databases

BioCycSEPI176279:SERP2056-MONOMER.

Family and domain databases

InterProIPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
[Graphical view]
PfamPF00483. NTP_transferase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01099. galU. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGTAB_STAEQ
AccessionPrimary (citable) accession number: Q5HLD1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 15, 2005
Last modified: February 9, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents