Q5HLD1 (GTAB_STAEQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UTP--glucose-1-phosphate uridylyltransferase
EC=2.7.7.9

Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name=UDPGP
Uridine diphosphoglucose pyrophosphorylase

Gene names

Name:	gtaB
Synonyms:	galU
Ordered Locus Names:	SERP2056

Organism

Staphylococcus epidermidis (strain ATCC 35984 / RP62A) [Complete proteome] [HAMAP]

Taxonomic identifier

176279 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus epidermidis

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. a glycolipid found in the membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) By similarity.
Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Pathway	Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis.
Sequence similarities	Belongs to the UDPGP type 2 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro enterobacterial common antigen biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	UTP--glucose-1-phosphate uridylyltransferase		PRO_0000308310

Sequences

	Sequence		Length	Mass (Da)
	Q5HLD1 [UniParc]. Last modified February 15, 2005. Version 1. Checksum: ED5422E73E60672F	FASTA	288	32,424
	10 20 30 40 50 60 MKKIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEASKAGI EDIIIVTGKH 70 80 90 100 110 120 KRAIEDHFDN QKELEMVLEN KGKADLLEKV QYSTDLANIF YVRQKEQKGL GHAIHTAKQF 130 140 150 160 170 180 IGNEPFAVLL GDDIVESDTP AIKQLMDVYE ETGHSVIGVQ EVPESDTHRY GVIDPSAKEG 190 200 210 220 230 240 SRYEVRQFVE KPKQGTAPSN LAIMGRYVLT PEIFDYLETQ QEGAGNEIQL TDAIERMNSK 250 260 270 280 QQVYAYDFEG NRYDVGEKLG FVKTTIEYAL KDPEMSQDLK AFIKQLDI

References

[1]

"Insights on evolution of virulence and resistance from the complete genome analysis of an early methicillin-resistant Staphylococcus aureus strain and a biofilm-producing methicillin-resistant Staphylococcus epidermidis strain." Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J., Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J., Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H., Vamathevan J.J., Khouri H. , Utterback T.R., Lee C., Dimitrov G., Jiang L., Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E., Fraser C.M. J. Bacteriol. 187:2426-2438(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 35984 / RP62A.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000029 Genomic DNA. Translation: AAW52903.1.
RefSeq	YP_189612.1. NC_002976.3.
3D structure databases
HSSP	HSSP built from PDB template 1IIN based on UniProtKB P26393.
ProteinModelPortal	Q5HLD1.
ModBase	Search...
Protein-protein interaction databases
STRING	176279.SERP2056.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAW52903; AAW52903; SERP2056.
GeneID	3242255.
KEGG	ser:SERP2056.
PATRIC	19615028. VBIStaEpi130894_2003.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1210.
HOGENOM	HOG000283477.
KO	K00963.
OMA	HETHAST.
ProtClustDB	CLSK746178.
Enzyme and pathway databases
BioCyc	SEPI176279:GJJB-2133-MONOMER.
UniPathway	UPA00894.
Family and domain databases
InterPro	IPR005771. GalU_uridylyltTrfase_bac/arc. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01099. galU. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GTAB_STAEQ

Accession

Primary (citable) accession number: Q5HLD1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	February 15, 2005
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program